Scientists "have made a discovery that may help prevent some people from developing lung cancer," reports the New York Times, noting that lung cancer "kills more people worldwide than any other cancer." A team of more than 80 researchers working across four continents have identified a set of proteins in the blood that accurately predict lung cancers more than five years before diagnosis. The scientists also found early evidence that an existing anti-inflammatory drug could significantly reduce lung cancer risk in people with elevated concentrations of these proteins, which they linked to inflammation. More research is needed before a test based on these proteins could be ready for use in patients. And scientists would still need to run a randomized trial to determine whether the drug prevents lung cancers. Still, outside experts said the findings, which were published on Thursday in the journal Cell, offer a promising starting point toward a long-held public health goal... Led by Dr. Swanton, Dr. Tej Pandya, a Ph.D. student, and other researchers took a set of 48,000 blood samples from the UK Biobank and used machine learning to identify 14 proteins associated with the development of lung cancer. When the researchers looked at the presence of those proteins and also took into account a patient's age, smoking status and history of lung disease, they were able to predict who would develop lung cancer more accurately than the best risk assessment models currently in use... Using mouse and cell models, the scientists showed that these proteins increased when a specific inflammatory pathway was activated. Smoking and air pollution can activate that pathway. This adds to the evidence that it isn't just genetic mutations caused by smoking, pollution or other factors that are driving lung cancers. Rather, Dr. Swanton said, the findings suggest that "smoke causes mutations and inflammation, which together cause cancer." They also found that the signature was increased in people who later developed chronic obstructive pulmonary disease and pulmonary fibrosis, pointing to a common inflammatory environment upstream of all three diseases.

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"Think Olympics on steroids. Literally," quips the BBC, describing Sunday's controversial Enhanced Games event in Las Vegas featuring dozens of athletes "using performance-enhancing drugs to try and break world records in track, weightlifting and swimming. Some $25m (£18.6m) in prize money is up for grabs — with cash prizes for winners... The drugs they use must be legal, and approved by the Federal Drug Administration. But substances like testosterone and human growth hormone — banned by the World Anti-Doping Agency — are not only celebrated here, they're encouraged and for sale... Health experts warn that anabolic steroids and growth hormones can cause strokes and cardiovascular damage, among other risks. Event organisers claim Enhanced will push the limits of human performance while critics, especially in the Olympic movement, dismiss it as an affront to the spirit and founding principles of competitive sport... Earlier this month, the Enhanced Group — the company behind the competition — began trading on the New York Stock Exchange. And the competition is seemingly being treated as an opportunity for Enhanced to sell performance-enhancing medicine and supplements online. "The project was founded by entrepreneurs Aron D'Souza and Maximilian Martin in 2023," the artidcle points out, "and has attracted backing from prominent investors including billionaire Peter Thiel and Donald Trump Jr." And NPR adds that "Most of the participating athletes trained for the competition in Abu Dhabi, as part of Enhanced's own study." Enhanced did not break down what specific athletes used which drugs, but they announced on Wednesday in the lead-up to the event that 91% of the athletes competing used testosterone or testosterone esters, 79% used human growth hormone, and 62% used stimulants, such as adderall... The games have been largely panned by outside medical experts and sports governing bodies. Multiple recent studies assess the harm surrounding the Enhanced Games. Travis Tygart, the CEO of the U.S. Anti-Doping Agency, called the games a "dangerous clown show that puts profit over principle" in a statement. The International Olympic Committee said the games are a "betrayal of everything that we stand for." The World Anti-Doping Agency (WADA) last year urged U.S. authorities to stop the games. The International Federation of Sports Medicine said in 2024 that they see the medical oversight as "insufficient" to support the athletes.

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Colossal Biosciences says it has grown chickens inside 3D-printed artificial eggshells. "The company says the egg technology could help conserve at-risk bird species," reports MIT Technology. "It could also play a role in a project to re-create the extinct giant moa, a flightless 12-foot-tall bird that once lived in New Zealand and laid four-liter eggs, larger than those of any living bird." From the report: The biotech company today claimed it has developed a "fully artificial egg" as part of its effort to resurrect extinct avian species, including birds like the dodo and the giant moa. But "artificial eggshell" would probably be a better description for the invention. It's an oval-shaped printed lattice, coated inside with a special silicone-based membrane that lets in oxygen, just as a real eggshell does. To generate birds, Colossal took recently laid chicken eggs and carefully poured their contents into the artificial shells, where they continued growing. A window on top lets researchers peek inside. "To see them all moving around in their artificial eggs was absolutely mind blowing," says Andrew Pask, the company's chief biology officer. "You really feel you can grow life outside of the womb." [...] The work on the artificial eggshell was carried out in Dallas by Colossal's exogenous development team, or Exo Dev. That group is also trying to develop artificial wombs for mammals, starting with marsupials. "We're looking at every single facet of what's happening during a mammalian pregnancy to unpack exactly how we then go about recapitulating that," says Pask. For that team, an artificial eggshell is a relatively quick and easy technical win. That's because chickens are already an example of ex utero development. After an egg is laid, a small embryo sitting on top of the yolk starts growing, drawing nutrients from the yolk, the white, and even the shell, which provides calcium. (Colossal says it has to add ground-up calcium to the artificial eggs.) In order to create a moa, Colossal will have to genetically alter another type of bird, changing potentially thousands of DNA letters. But so far, chickens are the only bird species that can be genetically engineered. And that's via a tricky process of editing stem cells that produce egg and sperm. Scientists have to add or delete DNA letters from these cells and then inject them back into an egg. The resulting bird will carry the genetic changes in its gonads -- and then be able to pass them on. Pask says Colossal's idea is that it could modify avian stem cells enough to produce moa-like sperm or eggs. But then you might have the odd situation of a chicken laying an egg with a moa embryo inside it. "You would have chickens making moa egg and moa sperm. But it's still a chicken egg," he says.

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