Moderna shares plunged as much as 25% after partial clinical trial data leaked for its personalized cancer vaccine developed with Merck, despite the full results showing promising outcomes for melanoma patients. Analysts attribute the selloff largely to inflated investor expectations rather than disappointing clinical results. CNBC reports: The personalized vaccine, known as intismeran autogene, paired with Merck's immunotherapy Keytruda reduced the risk of recurrence or death in certain melanoma patients by 42% compared with Keytruda alone. The data also showed the shot along with Keytruda reduced the risk of cancer spreading to distant parts of the body or death by 38%, compared with just the immunotherapy. The companies say about 82% of patients who received the personalized cancer vaccine alongside Keytruda were alive without their melanoma returning at two years, compared with 70% of those who received Keytruda alone. [...] Investors see the targeted vaccine as a possible breakthrough treatment, with the potential to be used in other forms of cancer in the future. It could also offer Moderna a critical additional commercial product in its pipeline, following vaccines for Covid-19, the flu and respiratory syncytial virus. "We assert this relative reduction in recurrence/death is clinically meaningful," said BMO Capital Markets analyst Evan Seigerman. "Such a reaction likely reflects inflated expectations into the full data release, rather than a true indictment on the efficacy of the combo therapy." UBS analysts said "this is overall a strong data set" and gives more confidence in upcoming studies of the vaccine in kidney and bladder cancers. They added the stock reaction may be due more to massive expectations than disappointing data.

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An anonymous reader quotes a report from Wired: Longtime audio giant Bose announced on Wednesday that it's acquiring Skullcandy, the lifestyle brand known for its bass-heavy headphones. Skullcandy will remain a separate company within Bose's Premium Consumer Audio business and will still be based in Park City, Utah. The acquisition isn't out of left field. Bose has lent its audio expertise to Skullcandy over the past year under its Sound by Bose licensing program. Skullcandy designs the headphones and then works with Bose on the audio front. The relationship began with the Skullcandy Method 360 ANC earbuds in 2025 and more recently, with the Crusher 1080 ANC headphones in July. [...] This is hardly Bose's first audio acquisition (though it may be the most mainstream). Bose acquired McIntosh Group, owners of luxury audio brands McIntosh Laboratory and Sonus Faber, back in 2024. But Bose seems to be after Skullcandy's connection to its community. "What does the brand stand for? Does it have meaning for consumers? Is it relevant to a group of consumers that, frankly, we otherwise aren't reaching?" Bose CEO Lila Snyder tells WIRED. "If you think about McIntosh, Sonus Faber, and Skullcandy, they all fit into that realm. Skullcandy gives us access to a customer base that we think we're largely missing with the Bose brand." That's why Bose has no plans to relocate Skullcandy from Park City, Utah, which Snyder says is the epicenter of board sports culture. "We want to make sure we're right at the heart of it, as they always have been," she says. Skullcandy products are also affordable, especially compared to other Bose products and Bose-owned brands, which lets Bose compete at both ends of the market.

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Airbnb is banning hosts from requiring guests to perform time-consuming checkout chores, including washing dishes, stripping beds, doing laundry, and taking trash off-site. The updated policy applies to reservations booked on or after November 20. The Verge reports: Airbnb is displaying hosts' requests more prominently now in a new "rules and requests" section on listings. You might see an "includes cleaning requests" warning if a host leaves chore requests in their listing after the new policy goes into effect. Hosts aren't allowed to sneak in extra rules in messages to guests or on signs around their property, either. Some hosts pushed back on the house rules restrictions on Airbnb's forums, saying they pose health risks and arguing that guests can simply choose not to stay at listings with overly-strict rules. Airbnb says there can be exceptions to the limits on checkout chores, like asking guests to "dispose of trash in an animal-proof container in bear country."

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