A recent article in Noema magazines explores the issues in "editing nature to fix our failures."
"It turns out playing God is neither difficult nor expensive," the article points out. "For about $2,000, I can go online and order a decent microscope, a precision injection rig, and a vial of enough CRISPR-Cas9 — an enzyme-based genome-editing tool — to genetically edit a few thousand fish embryos..." So when going beyond the kept-in-captivity Dire Wolf to the possibility of bringing back forests of the American chestnut tree, "The process is deceptively simple; the implications are anything but..."
If scientists could use CRISPR to engineer a more heat-tolerant coral, it would give coral a better chance of surviving a marine environment made warmer by climate change. It would also keep the human industries that rely on reefs afloat. But should we edit nature to fix our failures? And if we do, is it still natural...? Evolution is not keeping pace with climate change, so it is up to us to give it an assist [according to Christopher Preston, an environmental philosopher from the University of Montana, who wrote a book on CRISPR called "Ma href="https://mitpress.mit.edu/9780262537094/the-synthetic-age/">The Synthetic Age."] In some cases, the urgency is so great that we may not have time to waste. "There's no doubt there are times when you have to act," Preston continued. "Corals are a case where the benefits of reefs are just so enormous that keeping some alive, even if they're genetically altered, makes the risks worth it."
Kate Quigley, a molecular ecologist and a principal research scientist at Australia's Minderoo Foundation, says "Engineering the ocean, or the atmosphere, or coral is not something to be taken lightly. Science is incredible. But that doesn't mean we know everything and what the unintended consequences might be." Phillip Cleves, a principal investigator at the Carnegie Institute for Science's embryology department, is already researching whether coral could be bioengineered to be more tolerant to heat.
But both of them have concerns:
For all the research Quigley and Cleves have dedicated to climate-proofing coral, neither wants to see the results of their work move from experimentation in the lab to actual use in the open ocean. Needing to do so would represent an even greater failure by humankind to protect the environment that we already have. And while genetic editing and selective breeding offer concrete solutions for helping some organisms adapt, they will never be powerful enough to replace everything lost to rising water temperatures. "I will try to prepare for it, but the most important thing we can do to save coral is take strong action on climate change," Quigley told me. "We could pour billions and billions of dollars — in fact, we already have — into restoration, and even if, by some miracle, we manage to recreate the reef, there'd be other ecosystems that would need the same thing. So why can't we just get at the root issue?"
And then there's the blue-green algae dilemma:
George Church, the Harvard Medical School professor of genetics behind Colossal's dire wolf project, was part of a team that successfully used CRISPR to change the genome of blue-green algae so that it could absorb up to 20% more carbon dioxide via photosynthesis. Silicon Valley tech incubator Y Combinator seized on the advance to call for scaled-up proposals, estimating that seeding less than 1% of the ocean's surface with genetically engineered phytoplankton would sequester approximately 47 gigatons of CO2 a year, more than enough to reverse all of last year's worldwide emissions.
But moving from deploying CRISPR for species protection to providing a planetary service flips the ethical calculus. Restoring a chestnut forest or a coral reef preserves nature, or at least something close to it. Genetically manipulating phytoplankton and plants to clean up after our mistakes raises the risk of a moral hazard. Do we have the right to rewrite nature so we can perpetuate our nature-killing ways?
Read more of this story at Slashdot.
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