Amazon "has submitted plans for a large-format store near Chicago that would be larger than a Walmart Supercenter," reports CNBC: As part of the plans, Amazon has proposed building a one-story, 229,000-square-foot building [on a 35-acre lot] in Orland Park, Illinois, that would offer a range of products, such as groceries, household essentials and general merchandise, the city said on Saturday. By comparison, Walmart's U.S. Supercenters typically average 179,000 square feet... The Orland Park Plan Commission approved Amazon's proposal on Tuesday, and it will now proceed to a vote from the full village board. That meeting is scheduled for January 19. In a statement cited by CNBC, an Amazon spokesperson called it "a new concept that we think customers will be excited about."

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"Scientists in China have made a breakthrough with fusion energy that could finally overcome one of the most stubborn barriers to realising the next-generation energy source," reports the Independent: A team from the Chinese Academy of Sciences (CAS) said its experimental nuclear reactor, dubbed the 'artificial Sun', achieved a plasma density that was previously thought impossible... Through a new process called plasma-wall self organisation, the CAS researchers were able to keep the plasma stable at unprecedented density levels. By pushing plasma density well past long-standing empirical limits, the researchers said fusion ignition can be achieved with far higher energy outputs. "The findings suggest a practical and scalable pathway for extending density limits in tokamaks and next-generation burning plasma fusion devices," said Professor Ping Zhu from Huazhong University of Science and Technology, who so-led the research. Professor Zhu's team now plan to apply this new method on the EAST reactor to confirm that it will work under high-performance plasma conditions. The latest breakthrough was detailed in the journal Science Advances in a study titled 'Accessing the density-free regime with ECRH-assisted ohmic start-up on EAST'.

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This week Meta announced several new features for "Meta Ray-Ban Display" smartglasses: - A new teleprompter feature for the smart glasses (arriving in a phased rollout) - The ability to send messages on WhatsApp and Messenger by writing with your finger on any surface. (Available for those who sign up for an "early access" program). - "Pedestrian navigation" for 32 cities. ("The 28 cities we launched Meta Ray-Ban Display with, plus Denver, Las Vegas, Portland, and Salt Lake City," and with more cities coming soon.) But they also warned Meta Ray-Ban Display "is a first-of-its-kind product with extremely limited inventory," saying they're delaying international expansion of sales due to inventory constraints — and also due to "unprecedented" demand in the U.S. CNBC reports: "Since launching last fall, we've seen an overwhelming amount of interest, and as a result, product waitlists now extend well into 2026," Meta wrote in a blog post. Due to "limited" inventory, the company said it will pause plans to launch in the U.K., France, Italy and Canada early this year and concentrate on U.S. orders as it reassesses international availability... Meta is one of several technology companies moving into the smart glasses market. Alphabet announced a $150 million partnership with Warby Parker in May and ChatGPT maker OpenAI is reportedly working on AI glasses with Apple.

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It will be the first medical evacuation from the International space station in its 25-year history. The Guardian reports: An astronaut in the orbital laboratory reportedly fell ill with a "serious" but undisclosed issue. Nasa also had to cancel its first spacewalk of the year... The agency did not identify the astronaut or the medical problem, citing patient privacy. "Because the astronaut is absolutely stable, this is not an emergent evacuation," [chief health and medical officer Dr. James] Polk said. "We're not immediately disembarking and getting the astronaut down, but it leaves that lingering risk and lingering question as to what that diagnosis is, and that means there is some lingering risk for that astronaut onboard." "SpaceX says it's Dragon spacecraft at the International Space Station is ready to return its four Crew-11 astronauts home in an unprecedented medical evacuation on Jan. 14 and 15," reports Space.com: The SpaceX statement came on the heels of NASA's announcement that the Crew-11 astronauts were scheduled to undock from the space station on Jan. 14 and splashdown off the coast of California early on Jan. 15. The Crew-11 Dragon spacecraft will return NASA astronauts Zena Cardman and Mike Fincke to Earth alongside Japanese astronaut Kimiya Yui and Russian cosmonaut Oleg Platanov... NASA officials opted for a "controlled medical evacuation" in order to provide the astronaut better treatment on the ground, NASA chief Jared Isaacman has said... Dr. James Polk, NASA's chief medical officer, has said the medical issue is not an injury to the astronaut afflicted, but rather something related to the prolonged exposure to weighlessness by astronauts living and working on the International Space Station. "It's mostly having a medical issue in the difficult areas of microgravity and the suite of hardware that we operate in," Polk said.

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Yes, a federal judge blocked an attempt by Texas at an app store age-verification law. But this year Silicon Valley giants including Google and Apple "are expected to fight hard against similar legislation," reports Politico, "because of the vast legal liability it imposes on app stores and developers." In Texas, Utah and Louisiana, parent advocates have linked up with conservative "pro-family" groups to pass laws forcing mobile app stores to verify user ages and require parental sign-off. If those rules hold up in court, companies like Google and Apple, which run the two largest app stores, would face massive legal liability... California has taken a different approach, passing its own age-verification law last year that puts liability on device manufacturers instead of app stores. That model has been better received by the tech lobby, and is now competing with the app-based approach in states like Ohio. In Washington D.C., a GOP-led bill modeled off of Texas' law is wending its way through Capitol Hill. And more states are expected to join the fray, including Michigan and South Carolina. Joel Thayer, president of the conservative Digital Progress Institute and a key architect of the Texas law, said states are only accelerating their push. He explicitly linked the age-verification debate to AI, arguing it's "terrifying" to think companies could build new AI products by scraping data from children's apps. Thayer also pointed to the Trump administration's recent executive order aimed at curbing state regulation of AI, saying it has galvanized lawmakers. "We're gonna see more states pushing this stuff," Thayer said. "What really put fuel in the fire is the AI moratorium for states. I think states have been reinvigorated to fight back on this." He told Politico that the issue will likely be decided by America's Supreme Court, which in June upheld Texas legislation requiring age verification for online content. Thayer said states need a ruling from America's highest court to "triangulate exactly what the eff is going on with the First Amendment in the tech world. "They're going to have to resolve the question at some point."

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The Free Software Foundation's president Ian Kelling is also their senior systems administrator. This week he shared an example of how "the work we put in to making sure a program is free for us also makes it free for the rest of the world." During the COVID-19 pandemic, like everyone everywhere, the FSF increased its videoconferencing use, especially videoconferencing software that works in web browsers. We have experience hosting several different programs to accomplish this, and BigBlueButton was an important one for us for a while. It is a videoconferencing service which describes itself as a virtual classroom because of its many features designed for educational environments, such as a shared whiteboard... In BigBlueButton 2.2, the program used a freely licensed version of MongoDB, but it unintentionally picked up MongoDB's 2018 nonfree license change in versions 2.3 and 2.4. At the FSF, we noticed this [after a four-hour review] and raised the alarm with the BigBlueButton team in late 2020. In many cases of a developer changing to a nonfree license, free forks have won out, but in this case no one judged it worth the effort to maintain a fork of the final free MongoDB version. This was a very unfortunate case for existing users of MongoDB, including the FSF, who were then faced with a challenge of maintaining their freedom by either running old and unmaintained software or switching over to a different free program. Luckily, the free software world is not especially lacking in high quality database software, and there is also a wide array of free videoconferencing software. At the FSF, we decided to spend some effort to make sure MongoDB would no longer make BigBlueButton nonfree, to help other users of MongoDB and BigBlueButton. We think BigBlueButton is really useful for free software in schools, where it is incredibly important to have free software. On the tech team, especially when it comes to software running in a web browser, we are used to making modifications to better suit our needs. In the end, we didn't find a perfect solution, but we did find FerretDB to be a promising MongoDB alternative and assisted the developers of FerretDB to see what would be required for it to work in BigBlueButton. The BigBlueButton developers decided that some architectural level changes for their 3.0 release would be the path for them to remove MongoDB. As of BigBlueButton 3.0, released in 2025, BigBlueButton is back to being entirely free software...! As you can see, in the world of free software, trust can be tricky, and this is part of why organizations like the FSF are so important. Kelling notes he's part of a tech team of just two people reponsible for "63 different services, platforms, and websites for the FSF staff, the GNU Project, other community projects, and the wider free software community..."

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An anonymous reader quotes a report from CBC.ca: A company largely owned by the French and U.K. governments is pitching Canada on a roughly $250-million plan to provide the military with secure satellite broadband coverage in the Arctic, CBC News has learned. Eutelsat, a rival to tech billionaire Elon Musk's Starlink, already provides some services to the Canadian military, but wants to deepen the partnership as Canada looks to diversify defence contracts away from suppliers in the United States. A proposal for Canada's Department of National Defence to join a French Ministry of Defence initiative involving Eutelsat was apparently raised by French President Emmanuel Macron with Prime Minister Mark Carney on the sidelines of last year's G7 summit in Alberta. The prime minister's first question, according to Eutelsat and French defence officials, was how the proposal would affect the Telesat Corporation, a former Canadian Crown corporation that was privatized in the 1990s. Telesat is in the process of developing its Lightspeed system, a Low Earth Orbit (LEO) constellation of satellites for high-speed broadband. And in mid-December, the Liberal government announced it had established a strategic partnership with Telesat and MDA Space to develop the Canadian Armed Forces' military satellite communications (MILSATCOM) capabilities. A Eutelsat official said the company already has its own satellite network in place and running, along with Canadian partners, and has been providing support to the Canadian military deployed in Latvia. "What we can provide for Canada is what we call a sovereign capacity capability where Canada would actually own all of our capacity in the Far North or wherever they require it," said David van Dyke, the general manager for Canada at Eutelsat. "We also give them the ability to not be under the control of a singular individual who could decide to disconnect the service for political or other reasons."

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Scientists are putting Einstein's claim that the speed of light is constant to the test. While researchers found no evidence that light's speed changes with energy, this null result dramatically tightens the constraints on quantum-gravity theories that predict even the tiniest violations. ScienceDaily reports: Special relativity rests on the principle that the laws of physics remain the same for all observers, regardless of how they are moving relative to one another. This idea is known as Lorentz invariance. Over time, Lorentz invariance became a foundational assumption in modern physics, especially within quantum theory. [...] One prediction shared by several Lorentz-invariance-violating quantum gravity models is that the speed of light may depend slightly on a photon's energy. Any such effect would have to be tiny to match existing experimental limits. However, it could become detectable at the highest photon energies, specifically in very-high-energy gamma rays. A research team led by former UAB student Merce Guerrero and current IEEC PhD student at the UAB Anna Campoy-Ordaz set out to test this idea using astrophysical observations. The team also included Robertus Potting from the University of Algarve and Markus Gaug, a lecturer in the Department of Physics at the UAB who is also affiliated with the IEEC. Their approach relies on the vast distances light travels across the universe. If photons of different energies are emitted at the same time from a distant source, even minuscule differences in their speeds could build up into measurable delays by the time they reach Earth. Using a new statistical technique, the researchers combined existing measurements of very-high-energy gamma rays to examine several Lorentz-invariance-violating parameters favored by theorists within the Standard Model Extension (SME). The goal was ambitious. They hoped to find evidence that Einstein's assumptions might break down under extreme conditions. Once again, Einstein's predictions held firm. The study did not detect any violation of Lorentz invariance. Even so, the results are significant. The new analysis improves previous limits by an order of magnitude, sharply narrowing where new physics could be hiding.

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Meta has signed long-term nuclear power deals totaling more than 6 gigawatts to fuel its data centers: "one from a startup, one from a smaller energy company, and one from a larger company that already operates several nuclear reactors in the U.S," reports TechCrunch. From the report: Oklo and TerraPower, two companies developing small modular reactors (SMR), each signed agreements with Meta to build multiple reactors, while Vistra is selling capacity from its existing power plants. [...] The deals are the result of a request for proposals that Meta issued in December 2024, in which Meta sought partners that could add between 1 to 4 gigawatts of generating capacity by the early 2030s. Much of the new power will flow through the PJM interconnection, a grid which covers 13 Mid-Atlantic and Midwestern states and has become saturated with data centers. The 20-year agreement with Vistra will have the most immediate impact on Meta's energy needs. The tech company will buy a total of 2.1 gigawatts from two existing nuclear power plants, Perry and Davis-Besse in Ohio. As part of the deal, Vistra will also add capacity to those power plants and to its Beaver Valley power plant in Pennsylvania. Together, the upgrades will generate an additional 433 MW and are scheduled to come online in the early 2030s. Meta is also buying 1.2 gigawatts from young provider Oklo. Under its deal with Meta, Oklo is hoping to start supplying power to the grid as early as 2030. The SMR company went public via SPAC in 2023, and while Oklo has landed a large deal with data center operator Switch, it has struggled to get its reactor design approved by the Nuclear Regulatory Commission. If Oklo can deliver on its timeline, the new reactors would be built in Pike County, Ohio. The startup's Aurora Powerhouse reactors each produce 75 megawatts of electricity, and it will need to build more than a dozen to fulfill Meta's order. TerraPower is a startup co-founded by Bill Gates, and it is aiming to start sending electricity to Meta as early as 2032.

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An anonymous reader quotes a report from Wired: [P]erhaps AI can, in fact, learn in a more human way -- by figuring out interesting questions to ask itself and attempting to find the right answer. A project from Tsinghua University, the Beijing Institute for General Artificial Intelligence (BIGAI), and Pennsylvania State University shows that AI can learn to reason in this way by playing with computer code. The researchers devised a system called Absolute Zero Reasoner (AZR) that first uses a large language model to generate challenging but solvable Python coding problems. It then uses the same model to solve those problems before checking its work by trying to run the code. And finally, the AZR system uses successes and failures as a signal to refine the original model, augmenting its ability to both pose better problems and solve them. The team found that their approach significantly improved the coding and reasoning skills of both 7 billion and 14 billion parameter versions of the open source language model Qwen. Impressively, the model even outperformed some models that had received human-curated data. [...] A key challenge is that for now the system only works on problems that can easily be checked, like those that involve math or coding. As the project progresses, it might be possible to use it on agentic AI tasks like browsing the web or doing office chores. This might involve having the AI model try to judge whether an agent's actions are correct. One fascinating possibility of an approach like Absolute Zero is that it could, in theory, allow models to go beyond human teaching. "Once we have that it's kind of a way to reach superintelligence," [said Zilong Zheng, a researcher at BIGAI who worked on the project].

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Experts interviewed by NBC News warn that the rapid spread of AI-generated images and videos is accelerating an online trust breakdown, especially during fast-moving news events where context is scarce. From the report: President Donald Trump's Venezuela operation almost immediately spurred the spread of AI-generated images, old videos and altered photos across social media. On Wednesday, after an Immigration and Customs Enforcement officer fatally shot a woman in her car, many online circulated a fake, most likely AI-edited image of the scene that appears to be based on real video. Others used AI in attempts to digitally remove the mask of the ICE officer who shot her. The confusion around AI content comes as many social media platforms, which pay creators for engagement, have given users incentives to recycle old photos and videos to ramp up emotion around viral news moments. The amalgam of misinformation, experts say, is creating a heightened erosion of trust online -- especially when it mixes with authentic evidence. "As we start to worry about AI, it will likely, at least in the short term, undermine our trust default -- that is, that we believe communication until we have some reason to disbelieve," said Jeff Hancock, founding director of the Stanford Social Media Lab. "That's going to be the big challenge, is that for a while people are really going to not trust things they see in digital spaces." Though AI is the latest technology to spark concern about surging misinformation, similar trust breakdowns have cycled through history, from election misinformation in 2016 to the mass production of propaganda after the printing press was invented in the 1400s. Before AI, there was Photoshop, and before Photoshop, there were analog image manipulation techniques. Fast-moving news events are where manipulated media have the biggest effect, because they fill in for the broad lack of information, Hancock said. "In terms of just looking at an image or a video, it will essentially become impossible to detect if it's fake. I think that we're getting close to that point, if we're not already there," said Hancock. "The old sort of AI literacy ideas of 'let's just look at the number of fingers' and things like that are likely to go away." Renee Hobbs, a professor of communication studies at the University of Rhode Island, added: "If constant doubt and anxiety about what to trust is the norm, then actually, disengagement is a logical response. It's a coping mechanism. And then when people stop caring about whether something's true or not, then the danger is not just deception, but actually it's worse than that. It's the whole collapse of even being motivated to seek truth."

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Intel CEO Lip-Bu Tan says the company is "going big time" into its 14A (1.4nm-class) process, signaling confidence in yields and hinting at at least one external foundry customer. Tom's Hardware reports: Intel's 14A is expected to be production-ready in 2027, with early versions of process design kit (PDK) coming to external customers early this year. To that end, it is good to hear Intel's upbeat comments about 14A. Also, Tan's phrasing 'the customer' could indicate that Intel has at least one external client for 14A, implying that Intel Foundry will produce 14A chips for Intel Products and at least one more buyer. The 14A production node will introduce Intel's 2nd Generation RibbonFET GAA transistors; 2nd Gen BSPDN called PowerDirect that will connect power directly to source and drain of transistors, enabling better power delivery (e.g., reducing transient voltage droop or clock stretching) and refined power controls; and Turbo Cells that optimize critical timing paths using high-drive, double-height cells within dense standard cell libraries, which boost speed without major area or power compromises. Yet, there is another aspect of Intel's 14A manufacturing process that is particularly important for the chipmaker: its usage by external customers. With 18A, the company has not managed to land a single major external client that demands decent volumes. While 18A will be used by Intel itself as well as by Microsoft and the U.S. Department of Defense, only Intel will consume significant volumes. For 14A, Intel hopes to land at least one more external customer with substantial volume requirements, as this will ensure that Intel will recoup its investments in the development of such an advanced node.

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Microsoft is testing a new Windows policy that lets IT administrators uninstall Microsoft Copilot from managed devices. The change rolls out via Windows Insider builds and works through standard management tools like Intune and SCCM. BleepingComputer reports: The new policy will apply to devices where the Microsoft 365 Copilot and Microsoft Copilot are both installed, the Microsoft Copilot app was not installed by the user, and the Microsoft Copilot app was not launched in the last 28 days. "Admins can now uninstall Microsoft Copilot for a user in a targeted way by enabling a new policy titled RemoveMicrosoftCopilotApp," the Windows Insider team said. "If this policy is enabled, the Microsoft Copilot app will be uninstalled, once. Users can still re-install if they choose to. This policy is available on Enterprise, Pro, and EDU SKUs. To enable this policy, open the Group policy editor and go to: User Configuration -> Administrative Templates -> Windows AI -> Remove Microsoft Copilot App."

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An anonymous reader quotes a report from Ars Technica: Search engine optimization, or SEO, is a big business. While some SEO practices are useful, much of the day-to-day SEO wisdom you see online amounts to superstition. An increasingly popular approach geared toward LLMs called "content chunking" may fall into that category. In the latest installment of Google's Search Off the Record podcast, John Mueller and Danny Sullivan say that breaking content down into bite-sized chunks for LLMs like Gemini is a bad idea. You've probably seen websites engaging in content chunking and scratched your head, and for good reason -- this content isn't made for you. The idea is that if you split information into smaller paragraphs and sections, it is more likely to be ingested and cited by gen AI bots like Gemini. So you end up with short paragraphs, sometimes with just one or two sentences, and lots of subheads formatted like questions one might ask a chatbot. According to Google's Danny Sullivan, this is a misconception, and Google doesn't use such signals to improve ranking. "One of the things I keep seeing over and over in some of the advice and guidance and people are trying to figure out what do we do with the LLMs or whatever, is that turn your content into bite-sized chunks, because LLMs like things that are really bite size, right?" said Sullivan. "So... we don't want you to do that." The conversation, which begins around the podcast's 18-minute mark, goes on to illustrate the folly of jumping on the latest SEO trend. Sullivan notes that he has consulted engineers at Google before making this proclamation. Apparently, the best way to rank on Google continues to be creating content for humans rather than machines. That ensures long-term search exposure, because the behavior of human beings -- what they choose to click on -- is an important signal for Google.

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Longtime Slashdot reader chicksdaddy writes: CES, the Consumer Electronics Show, isn't just about shiny new gadgets. As AP reports, this year brought back the fifth annual Worst in Show anti-awards, calling out the most harmful, wasteful, invasive, and unfixable tech at the Las Vegas show. The coalition behind the awards -- including Repair.org, iFixit, EFF, PIRG, Secure Repairs, and others -- put the spotlight on products that miss the point of innovation and make life worse for users. 2026 Worst in Show winners include: Overall (and Repairability): Samsung's AI-packed Family Hub Fridge -- over-engineered, hard to fix, and trying to do everything but keep food cold. Privacy: Amazon Ring AI -- expanding surveillance with features like facial recognition and mobile towers. Security: Merach UltraTread treadmill -- an AI fitness coach that also hoovers up sensitive data with weak security guarantees, including a privacy policy that declares the company "cannot guarantee the security of your personal information" (!!). Environmental Impact: Lollipop Star -- a single-use, music-playing electronic lollipop that epitomizes needless e-waste. Enshittification: Bosch eBike Flow App -- pushing lock-in and digital restrictions that make gear worse over time. "Who Asked For This?": Bosch Personal AI Barista -- a voice-assistant coffee maker that nobody really wanted. People's Choice: Lepro Ami AI Companion -- an overhyped "soulmate" cam that creeps more than it comforts. The message? Not all tech is progress. Some products add needless complexity, threaten privacy, or throw sustainability out the window -- and the industry's watchdogs are calling them out.

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Valve has added the NTSYNC kernel driver to the SteamOS 3.7.20 beta, laying the groundwork for improved Windows game synchronization performance via Wine and Proton. Phoronix reports: For gearing up for that future Proton NTSYNC support, SteamOS 3.7.20 enables the NTSYNC kernel driver and loads the module by default. Most Linux distributions are at least already building the NTSYNC kernel module though there's been different efforts on how to handle ensuring it's loaded when needed. The presence of the NTSYC kernel driver is the main highlight of the SteamOS 3.7.20 beta now available for testing.

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An anonymous reader quotes a report from TorrentFreak: Italy's communications regulator AGCOM imposed a record-breaking 14.2 million-euro fine on Cloudflare after the company failed to implement the required piracy blocking measures. Cloudflare argued that filtering its global 1.1.1.1 DNS resolver would be "impossible" without hurting overall performance. AGCOM disagreed, noting that Cloudflare is not necessarily a neutral intermediary either. [...] "The measure, in addition to being one of the first financial penalties imposed in the copyright sector, is particularly significant given the role played by Cloudflare" AGCOM notes, adding that Cloudflare is linked to roughly 70% of the pirate sites targeted under its regime. In its detailed analysis, the regulator further highlighted that Cloudflare's cooperation is "essential" for the enforcement of Italian anti-piracy laws, as its services allow pirate sites to evade standard blocking measures. Cloudflare has strongly contested the accusations throughout AGCOM's proceedings and previously criticized the Piracy Shield system for lacking transparency and due process. While the company did not immediately respond to our request for comment, it will almost certainly appeal the fine. This appeal may also draw the interest of other public DNS resolvers, such as Google and OpenDNS. AGCOM, meanwhile, says that it remains fully committed to enforcing the local piracy law. The regulator notes that since the Piracy Shield started in February 2024, 65,000 domain names and 14,000 IP addresses were blocked.

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An anonymous reader shares a report: Microsoft is celebrating the resurgence of interest in physical media in the only way it knows how... by halting the Windows Media Player metadata service. Readers of a certain vintage will remember inserting a CD into their PC and watching Windows Media Player populate with track listings and album artwork. No more. Sometime before Christmas, the metadata servers stopped working and on Windows 10 or 11, the result is the same: album not found. We tried this out at Vulture Central on some sacrificial Windows devices that had media drives and can confirm that a variety of compact discs were met with stony indifference. Some 90s cheese that was successfully ripped (for personal use, of course) decades ago? No longer recognized. A reissue of something achingly hip? Also not recognized.

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The abstract of a paper on NBER: School boards have statutory authority over most elementary and secondary education policies, but receive little attention compared to other actors in education systems. A fundamental challenge to understanding the importance of boards is the absence of data on the policy goals of board members -- i.e., their ideologies -- forcing researchers to conduct tests based on demographic and professional characteristics -- i.e., identities -- with which ideology is presumed to correlate. This paper uses new data on the viewpoints and policy actions of school board members, coupled with a regression discontinuity design that generates quasi-random variation in board composition, to establish two results. The first is that the priorities of board members have large causal effects across many domains. For example, the effect of electing an equity-focused board member on test scores for low-income students is roughly equivalent to assigning every such student a teacher who is 0.3 to 0.4 SDs higher in the distribution of teacher value-added. The second is that observing policy priorities is crucial. Identity turns out to be a poor proxy for ideology, with limited governance effects that are fully explained by differences in policy priorities. Our findings challenge the belief that school boards are unimportant, showing that who serves on the board and what they prioritize can have far-reaching consequences for students.

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Microbiology had its golden age in the late nineteenth century, when researchers identified the bacterial causes of tuberculosis, cholera, typhoid, and a dozen other diseases in rapid succession. Antibiotics had theirs in the mid-twentieth century. Both booms eventually slowed. Vaccine development, by contrast, appears to be speeding up -- and the most productive era may still lie ahead, Works in Progress writes in a story. In the first half of the 2020s alone, researchers delivered the first effective vaccines against four different diseases: Covid-19, malaria, RSV and chikungunya. No previous decade matched that output. The acceleration rests on infrastructure that took two centuries to assemble. Edward Jenner's 1796 smallpox vaccine was a lucky accident he didn't understand. Louis Pasteur needed ninety years to turn that luck into systematic methods -- attenuation and inactivation -- that could be applied to other diseases. Generations of scientists then built the supporting machinery: Petri dishes for bacterial culture, techniques to keep animal cells alive outside the body, bioreactors for industrial production, sterilization and cold-chain logistics. Those tools have now compounded. Cryo-electron microscopy reveals viral proteins atom by atom, a capability that directly enabled the RSV vaccine after earlier attempts failed. Genome sequencing costs collapsed from roughly $100 million per human genome in 2001 to under $1,000 by 2014, according to data from the National Human Genome Research Institute. The mRNA platform, refined through work by Katalin Kariko, Drew Weissman, and others, allows vaccines to be redesigned in weeks rather than years. The trajectory suggests more breakthroughs are possible. Whether they arrive depends on continued investment, however.

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