Thursday the BBC reported: Plane bodies made by Boeing's largest supplier regularly left the factory with serious defects, according to a former quality inspector at the firm. Santiago Paredes who worked for Spirit AeroSystems in Kansas, told the BBC he often found up to 200 defects on parts being readied for shipping to Boeing. He was nicknamed "showstopper" for slowing down production when he tried to tackle his concerns, he claimed. Spirit said it "strongly disagree[d]" with the allegations. "We are vigorously defending against his claims," said a spokesperson for Spirit, which remains Boeing's largest supplier. Mr Paredes made the allegations against Spirit in an exclusive interview with the BBC and the American network CBS, in which he described what he said he experienced while working at the firm between 2010 and 2022... "I was finding a lot of missing fasteners, a lot of bent parts, sometimes even missing parts...." Mr Paredes told the BBC that some of the defects he identified while at Spirit were minor — but others were more serious. He also claimed he was put under pressure to be less rigorous... He now maintains he would be reluctant to fly on a 737 Max, in case it still carried flaws that originated in the Wichita factory. "I'd never met a lot of people who were scared of flying until I worked at Spirit," he said. "And then, being at Spirit, I met a lot of people who were afraid of flying — because they saw how they were building the fuselages." "If quality mattered, I would still be at Spirit," Paredes told CBS News, speaking publicly for the first time. CBS News spoke with several current and former Spirit AeroSystems employees and reviewed photos of dented fuselages, missing fasteners and even a wrench they say was left behind in a supposedly ready-to-deliver component. Paredes said Boeing knew for years Spirit was delivering defective fuselages. It could be just a coincidence, but the same day, the Associated Press ran story with this headline. "Boeing plane carrying 85 people catches fire and skids off the runway in Senegal, injuring 10." It was the third incident involving a Boeing airplane this week. Also on Thursday, 190 people were safely evacuated from a plane in Turkey after one of its tires burst during landing at a southern airport, Turkey's transportation ministry said.

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An anonymous reader shared this report from CNN: The "world's largest" plant designed to suck planet-heating pollution out of the atmosphere like a giant vacuum began operating in Iceland on Wednesday. "Mammoth" is the second commercial direct air capture plant opened by Swiss company Climeworks in the country, and is 10 times bigger than its predecessor, Orca, which started running in 2021... Climeworks plans to transport the carbon underground where it will be naturally transformed into stone, locking up the carbon permanently... The whole operation will be powered by Iceland's abundant, clean geothermal energy.... Climeworks started building Mammoth in June 2022, and the company says it is the world's largest such plant. It has a modular design with space for 72 "collector containers" — the vacuum parts of the machine that capture carbon from the air — which can be stacked on top of each other and moved around easily. There are currently 12 of these in place with more due to be added over the next few months. Mammoth will be able to pull 36,000 tons of carbon from the atmosphere a year at full capacity, according to Climeworks. That's equivalent to taking around 7,800 gas-powered cars off the road for a year... All the carbon removal equipment in the world is only capable of removing around 0.01 million metric tons of carbon a year, a far cry from the 70 million tons a year needed by 2030 to meet global climate goals, according to the International Energy Agency [7,000x more]... Jan Wurzbacher, the company's co-founder and co-CEO, said Mammoth is just the latest stage in Climeworks' plan to scale up to 1 million tons of carbon removal a year by 2030 and 1 billion tons by 2050. Plans include potential DAC plants in Kenya and the United States.

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"Google's business is growing at its fastest rate in two years," reports CNBC, "and a blowout earnings report in April sparked the biggest rally in Alphabet shares since 2015, pushing the company's market cap past $2 trillion. "But at an all-hands meeting last week with CEO Sundar Pichai and CFO Ruth Porat, employees were more focused on why that performance isn't translating into higher pay, and how long the company's cost-cutting measures are going to be in place." "We've noticed a significant decline in morale, increased distrust and a disconnect between leadership and the workforce," a comment posted on an internal forum ahead of the meeting read. "How does leadership plan to address these concerns and regain the trust, morale and cohesion that have been foundational to our company's success?" Google is using artificial intelligence to summarize employee comments and questions for the forum. Alphabet's top leadership has been on the defensive for the past few years, as vocal staffers have railed about post-pandemic return-to-office mandates, the company's cloud contracts with the military, fewer perks and an extended stretch of layoffs — totaling more than 12,000 last year — along with other cost cuts that began when the economy turned in 2022. Employees have also complained about a lack of trust and demands that they work on tighter deadlines with fewer resources and diminished opportunities for internal advancement. The internal strife continues despite Alphabet's better-than-expected first-quarter earnings report, in which the company also announced its first dividend as well as a $70 billion buyback. "Despite the company's stellar performance and record earnings, many Googlers have not received meaningful compensation increases" a top-rated employee question read. "When will employee compensation fairly reflect the company's success and is there a conscious decision to keep wages lower due to a cooling employment market?"

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This week, The Register reported: If you are still running RHEL 7, which is now approaching a decade old, there's good news. Red Hat is offering four more years of support for RHEL 7.9, which it terms Extended Life Cycle Support or ELS. If you are running the free version, CentOS Linux 7, that hits its end-of-life on the same date: June 30, 2024. CIQ, which offers CentOS Linux rebuild Rocky Linux, has a life cycle extension for that too, which it calls CIQ Bridge. The company told The Reg: "CIQ Bridge, essentially a long-term support service tailored for CentOS 7 users on the migration path to Rocky Linux, is offered under an annual, fixed-rate subscription. CIQ Bridge includes access to CentOS 7 extended life package updates for an additional three years and security updates for CVSS 7 issues and above. Security updates for CVSS 5 and 6 are available at an elevated subscription tier. CIQ Bridge is designed to support CentOS 7 users until they are ready for CIQ guidance and support in migration to Rocky Linux." CIQ believes there's a substantial market for this, and points to research from Enlyft that suggests hundreds of thousands of users still on CentOS Linux 7.

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Red Hat Enterprise Linux 9.4 has been released. But also released is Rocky Linux 9.4, reports 9to5Linux: Rocky Linux 9.4 also adds openSUSE's KIWI next-generation appliance builder as a new image build workflow and process for building images that are feature complete with the old images... Under the hood, Rocky Linux 9.4 includes the same updated components from the upstream Red Hat Enterprise Linux 9.4 This week also saw the release of Alma Linux 9.4 stable (the "forever-free enterprise Linux distribution... binary compatible with RHEL.") The Register points out that while Alma Linux is "still supporting some aging hardware that the official RHEL 9.4 drops, what's new is largely the same in them both." And last week also saw the launch of the AlmaLinux High-Performance Computing and AI Special Interest Group (SIG). HPCWire reports: "AlmaLinux's status as a community-driven enterprise Linux holds incredible promise for the future of HPC and AI," said Hayden Barnes, SIG leader and Senior Open Source Community Manager for AI Software at HPE. "Its transparency and stability empowers researchers, developers and organizations to collaborate, customize and optimize their computing environments, fostering a culture of innovation and accelerating breakthroughs in scientific research and cutting-edge AI/ML." And this week, InfoWorld reported: Red Hat has launched Red Hat Enterprise Linux AI (RHEL AI), described as a foundation model platform that allows users to more seamlessly develop and deploy generative AI models. Announced May 7 and available now as a developer preview, RHEL AI includes the Granite family of open-source large language models (LLMs) from IBM, InstructLab model alignment tools based on the LAB (Large-Scale Alignment for Chatbots) methodology, and a community-driven approach to model development through the InstructLab project, Red Hat said.

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Slashdot reader quonset writes: The last floppy disk was manufactured in 2011. Despite no new supplies being available for over a decade, there are still people, and organizations, who rely on floppy disks. Each has their own story as to why they rely on what is essentially 1970s technology. From the BBC: Tom Persky, a US businessman, has been selling "new", as in, unopened, floppy disks for years and still finds the trade lucrative. He runs Floppydisk.com, which offers disks for about US$1 (£0.80) each, though some higher capacity versions cost up to US$10 (£8) per disk, he says. Persky has customers all over the world and you could split them roughly 50-50 into hobbyists and enthusiasts like Espen Kraft on one side, and industrial users on the other. This latter category encompasses people who use computers at work that require floppy disks to function. They are, essentially, locked in to a format that the rest of the world has largely forgotten. "I sell thousands of floppy disks to the airline industry, still," says Persky. He declines to elaborate. "Companies are not happy about when I talk about them." But it is well-known that some Boeing 747s, for example, use floppy disks to load critical software updates into their navigation and avionics computers. While these older aircraft might not be so common in Europe or the US these days, you might find one in the developing world, for instance, Persky hints. There are also pieces of factory equipment, government systems — or even animatronic figures — that still rely on floppy disks. And in San Francisco, the Muni Metro light railway, which launched in 1980, won't start up each morning unless the staff in charge pick up a floppy disk and slip it into the computer that controls the railway's Automatic Train Control System, or ATCS. "The computer has to be told what it's supposed to do every day," explains a spokesman for the San Francisco Municipal Transport Agency (SFMTA). "Without a hard drive, there is nowhere to install software on a permanent basis." This computer has to be restarted in such a way repeatedly, he adds — it can't simply be left on, for fear of its memory degrading. The article also includes this quote from a cybersecurity expert at Pen Test Partners. "If floppy was the only interface, the only way to get malware on to [the computer] would be via said floppy disk. That's quite a limiting factor for the attacker..."

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Brian Shelton's type 1 diabetes was treated with an infusion of insulin-producing pancreas cells (grown from stem cells). In 2021, the New York Times reported: Now his body automatically controls its insulin and blood sugar levels. Shelton, now 64, may be the first person cured of the disease with a new treatment that has experts daring to hope that help may be coming for many of the 1.5 million Americans suffering from Type 1 diabetes. "It's a whole new life," Shelton said. Diabetes experts were astonished but urged caution. The study is continuing and will take five years, involving 17 people with Type 1 diabetes. "By fall 2023, three patients, including Shelton, had achieved insulin independence by day 180 post-transplant," MedScape reported (in January of 2024): In the phase 1/2 study, 14 patients with type 1 diabetes and impaired hypoglycemia awareness or recurrent hypoglycemia received portal vein infusions of VX-880 [Vertex Pharmaceutical's pancreatic islet cell replacement therapy] along with standard immunosuppression. As of the last data cut, all 14 patients demonstrated islet cell engraftment and production of endogenous insulin. After more than 90 days of follow-up, 13 of the patients have achieved A1c levels

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The Dillo browser dates back to 1999, writes the Register, with its own rendering engine. And now Dillo "has returned with a new release, version 3.1. "It's nearly nine years after version 3.05 appeared on the last day of June 2015." Version 3.1 incorporates dozens of fixes and improvements, as the official announcement describes. Project lead Rodrigo Arias Mallo announced his resurrection attempt on Hacker News early this year. He has taken the last available code from the project's Mercurial repository, incorporated about 25 outstanding fixes, and added as many again of his own. Dillo is a super-lightweight graphical web browser for Unix-like OSes, written using the Fast Light Toolkit. The latest version has a number of new features, although one of the most significant is support for Transport Layer Security. TLS is the successor to SSL, with a Microsoft-approved name. Dillo 3.1 supports it thanks to the Mbed-TLS library. It doesn't support frames, embedded media playback, or JavaSccript — but it can run on very low-end hardware... Thanks to Lproven (Slashdot reader #6,030) for sharing the news.

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"Does a levitating robot train on the moon sound far-fetched?" asks LiveScience. "NASA doesn't seem to think so, as the agency has just greenlit further funding for a study looking into the concept." The project, called "Flexible Levitation on a Track" (FLOAT), has been moved to phase two of NASA's Innovative Advanced Concepts program (NIAC) , which aims to develop "science fiction-like" projects for future space exploration. The FLOAT project could result in materials being transported across the moon's surface as soon as the 2030s, according to the agency... According to NASA's initial design, FLOAT will consist of magnetic robots levitating over a three-layer film track to reduce abrasion from dust on the lunar surface. Carts will be mounted on these robots and will move at roughly 1 mph (1.61 km/h). They could transport roughly 100 tons (90 metric tons) of material a day to and from NASA's future lunar base. "A durable, long-life robotic transport system will be critical to the daily operations of a sustainable lunar base in the 2030's," according to NASA's blog post, arguing it could be used to Transport moon materials mined to produce on-site resources like water, liquid oxygen, liquid hydrogen, or construction materials Transport payloads around the lunar base and to and from landing zones or other outposts Thanks to long-time Slashdot reader AmiMoJo for sharing the article.

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Thursday CNN reported: The Oscar-winning team behind the nearly $6 billion blockbuster "Lord of the Rings" and "The Hobbit" trilogies is reuniting to produce two new films. The first of the new projects from Sir Peter Jackson, Fran Walsh and Philippa Boyens is tentatively titled "Lord of the Rings: The Hunt for Gollum," Warner Bros. Discovery announced Thursday. It will be directed by "LOTR" alum Andy Serkis. But "amid the news," TMZ reports, "a famous short film about it got yanked ... only to be revived on YouTube a day later." A viral short film called "The Hunt for Gollum" — which got uploaded to YouTube about 15 years ago — has been praised among Tolkien fans for years as a stellar piece of fan fiction and art, which while not sanctioned by Warner Bros., still held its own and looked damn good. On Thursday, WB announced they were making a brand new installment to their film franchise with the same title — which led to the short being taken down on a copyright claim ... but it seems Warner has backed off, 'cause about 12 hours or so later, it's up again...! Sources with direct knowledge tell us the copyright claim got applied in error ... and the studio realized that, so they removed it and YouTube did their thing. The director of the short, Chris Bouchard, uploaded an email he got from YT saying the copyright claim had been released ... confirming WB retreated all on their own. He tells TMZ ... "We're just happy to hear folks remembered our film somewhat fondly, low-fi effort that it is. And grateful as of course fan films are in strange legal territory."

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What happened when OpenAI ran out of English-language training data in 2021? They just created a speech recognition tool that could transcribe the audio from YouTube videos, reports The New York Times, as part of an investigation arguing that tech companies "including OpenAI, Google and Meta have cut corners, ignored corporate policies and debated bending the law" in their search for AI training data. [Alternate URL here.] Some OpenAI employees discussed how such a move might go against YouTube's rules, three people with knowledge of the conversations said. YouTube, which is owned by Google, prohibits use of its videos for applications that are "independent" of the video platform. Ultimately, an OpenAI team transcribed more than 1 million hours of YouTube videos, the people said. The team included Greg Brockman, OpenAI's president, who personally helped collect the videos, two of the people said. The texts were then fed into a system called GPT-4... At Meta, which owns Facebook and Instagram, managers, lawyers and engineers last year discussed buying the publishing house Simon & Schuster to procure long works, according to recordings of internal meetings obtained by the Times. They also conferred on gathering copyrighted data from across the internet, even if that meant facing lawsuits. Negotiating licenses with publishers, artists, musicians and the news industry would take too long, they said. Like OpenAI, Google transcribed YouTube videos to harvest text for its AI models, five people with knowledge of the company's practices said. That potentially violated the copyrights to the videos, which belong to their creators. Last year, Google also broadened its terms of service. One motivation for the change, according to members of the company's privacy team and an internal message viewed by the Times, was to allow Google to be able to tap publicly available Google Docs, restaurant reviews on Google Maps and other online material for more of its AI products... Some Google employees were aware that OpenAI had harvested YouTube videos for data, two people with knowledge of the companies said. But they didn't stop OpenAI because Google had also used transcripts of YouTube videos to train its AI models, the people said. That practice may have violated the copyrights of YouTube creators. So if Google made a fuss about OpenAI, there might be a public outcry against its own methods, the people said. The article adds that some tech companies are now even developing "synthetic" information to train AI. "This is not organic data created by humans, but text, images and code that AI models produce — in other words, the systems learn from what they themselves generate."

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SiliconANGLE looks at how starting in 2021, Microsoft and Red Hat have formed "an unlikely partnership set to reshape the landscape of cloud computing..." First, their collective open-source capabilities will lead to co-developed solutions to simplify the modernization and migration of Red Hat technologies to the cloud, seamlessly integrating them with Microsoft's Azure platform, according to João Couto, EMEA VP and COO of cloud commercial solutions at Microsoft. "We have acquired GitHub, which is also one of the largest repositories of open source worldwide," he said. "In that context, it makes a lot of sense to work together with Red Hat." Transcribed from their interview: What we have been doing so far is making sure that we are co-developing solutions together with Red Hat. And making these solutions available to our customers — making it easy for customers to transform, to modernize [their] Red Hat technology running on-prem, and moving them into cloud using our own Microsoft cloud technology, but Red Hat solutions, in a very, very seamless, integrated way. And also leveraging all the entire portfolio of Red Hat automation tools, so that they can make it easier for customers not just to do the migration, but also to do management, run the operation, and all the troubleshooting also from the customer-care perspective. So that's basically an end-to-end partnership approach that we are taking... "[Customers] get an integrated support experience from Red Hat technical teams and Microsoft technical teams. And this means that these two technical teams are often colocated, so whenever a customer has a challenge, they are being answered by Microsoft and Red Hat technical teams, all working together to solve this challenge from the customer. So this brings also an increased level of confidence to customers to move to cloud... "We have both engineering teams from both sides working together to achieve this level of integration between the two solutions. So when you talk about Red Hat Enterprise Linux or when you have the Azure Red Hat OpenShift, which is a new solution that we have recently launched — these are solutions that using open source, are bringing in an additional level of integration, flexibility, automation to customers. So that they can migrate, and manage, their solutions in a more seamless way, and in a more easy way. So we are embedding this kind of overlying partnership from an open source perspective to bring these innovations live to customers."

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"Atmospheric levels of planet-warming carbon dioxide aren't just on their way to yet another record high this year," reports the Washington Post. "They're rising faster than ever, according to the latest in a 66-year-long series of observations." Carbon dioxide levels were 4.7 parts per million higher in March than they were a year earlier, the largest annual leap ever measured at the National Oceanic Atmospheric Administration laboratory atop a volcano on Hawaii's Big Island. And from January through April, CO2 concentrations increased faster than they have in the first four months of any other year... For decades, CO2 concentrations at Mauna Loa in the month of May have broken previous records. But the recent acceleration in atmospheric CO2, surpassing a record-setting increase observed in 2016, is perhaps a more ominous signal of failing efforts to reduce global greenhouse gas emissions and the damage they cause to Earth's climate. "Not only is CO2 still rising in the atmosphere — it's increasing faster and faster," said Arlyn Andrews, a climate scientist at NOAA's Global Monitoring Laboratory in Boulder, Colorado. A historically strong El Niño climate pattern that developed last year is a big reason for the spike. But the weather pattern only punctuated an existing trend in which global carbon emissions are rising even as U.S. emissions have declined and the growth in global emissions has slowed. The spike is "not surprising," said Ralph Keeling, director of the CO2 Program at Scripps Institution, "because we're also burning more fossil fuel than ever...." El Niño-linked droughts in tropical areas including Indonesia and northern South America mean less carbon storage within plants, Keeling said. Land-based ecosystems around the world tend to give off more carbon dioxide during El Niño because of the changes in precipitation and temperature the weather pattern brings, Andrews added. And for CO2 concentrations to fall back below 400 parts per million, it would take more than two centuries even if emissions dropped close to zero by the end of this century, she added. This year's reading "is more than 50 percent above preindustrial levels and the highest in at least 4.3 million years, according to NOAA."

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Wednesday Rest of World noticed an overlooked tech story in Argentina: Olga de León looked confused as she walked out of a nightclub on the edge of Buenos Aires on a recent Tuesday afternoon. She had just had her iris scanned. "No one told me what they'll do with my eye," de León, 57, told Rest of World. "But I did this out of need." De León, who lives off the $95 pension she receives from the state, had been desperate for money. Persuaded by her nephew, she agreed to have one of her irises scanned by Worldcoin, Sam Altman's blockchain project. In exchange, she received nearly $50 worth of WLD, the company's cryptocurrency. De León is one of about half a million Argentines who have handed their biometric data over to Worldcoin. Beaten down by the country's 288% inflation rate and growing unemployment, they have flocked to Worldcoin Orb verification hubs, eager to get the sign-up crypto bonus offered by the company. A network of intermediaries — who earn a commission from every iris scan — has lured many into signing up for the practice in Argentina, where data privacy laws remain weak. But as the popularity of Worldcoin skyrockets in the country, experts have sounded the alarm about the dangers of giving away biometric data. Two provinces are now pushing for legal investigations. "Seeing that [iris scans have] been banned in European countries, shouldn't we be trying to stop it, too?" Javier Smaldone, a software consultant and digital security expert, told Rest of World. Last month Worldcoin's web site announced that more than 10 million people in 160 countries had created a World ID and compatible wallet (performing 75 million transactions) — and that 5,195,475 people had also verified their World ID using Worldcoin's iris-scanning Orb. But the article notes a big drop in the number of countries even allowing Worldcoin's iris-scanning — from 25 to just eight. While in less than a year Worldcoin opened nearly 60 centers across Argentina...

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An anonymous reader shared this report from Mint: Elon Musk-owned social media platform X (formerly Twitter) has launched a new Grok AI-powered feature called 'Stories', which allows users to read summaries of a trending post on the social media platform. The feature is currently only available to X Premium subscribers on the iOS and web versions, and hasn't found its way to the Android application just yet... instead of reading the whole post, they'll have Grok AI summarise it to get the gist of those big news stories. However, since Grok, like other AI chatbots on the market, is prone to hallucination (making things up), X provides a warning at the end of these stories that says: "Grok can make mistakes, verify its outputs." "Access to xAI's chatbot Grok is meant to be a selling point to push users to buy premium subscriptions," reports TechCrunch: A snarky and "rebellious" AI, Grok's differentiator from other AI chatbots like ChatGPT is its exclusive and real-time access to X data. A post published to X on Friday by tech journalist Alex Kantrowitz lays out Elon Musk's further plan for AI-powered news on X, based on an email conversation with the X owner. Kantrowitz says that conversations on X will make up the core of Grok's summaries. Grok won't look at the article text, in other words, even if that's what people are discussing on the platform. The article notes that some AI companies have been striking expensive licensing deals with news publishers. But in X's case, "it's able to get at the news by way of the conversation around it — and without having to partner to access the news content itself."

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"Without San Francisco, Star Wars wouldn't exist," says David Reat, the culture studies director of the architecture department at Glasgow's University of Strathclyde. SFGate reports: Lucas was born and raised in Modesto, where his father expected him to run the family stationery store once he turned 18, but Lucas instead left for Los Angeles, where he studied film production at the University of Southern California, before moving to San Francisco. Despite all that these cities had to offer, Lucas constantly found himself conflicted over his feelings toward them. "The battle of living in the country versus living in the city is huge with Lucas," says Reat, who notes that this theme runs throughout the likes of "THX 1138," "American Graffiti" and the "Star Wars" series. "He sees cities as the givers and takers of things. He's fascinated by cities. He doesn't actually want to live in one. He now lives in a ranch near one. He wants to orbit them. He's a paradox." When Lucas moved to San Francisco in the late 1960s, there were a number of huge building projects taking place across the city that piqued the burgeoning filmmaker's interest, most notably the construction of BART and a new terminal at San Francisco airport. "Infrastructure really fascinated Lucas. They were these big huge alienating spaces," says Reat. "I think Lucas was driving around San Francisco, looking at them, and seeing that they looked alien." There's a reason why Lucas was particularly interested in the architecture in San Francisco: "He's on record as saying he wanted to be an architect," says Reat. "He has referred to himself as a frustrated architect." Lucas' interest provoked him and his creative team to put extra care and thought into each of the "Star Wars" buildings, vehicles, houses, villages, cities, worlds and galaxies, especially when it came to what they symbolized and represented. "The architecture in the films play a key role for younger viewers," says Reat, explaining that it helps to indicate who is good and who is evil. When it comes to the Death Star there are "no women, no plants, no signs of life, and it's basically the Nazis in space," continues Reat. "Lucas doesn't like modernism. He always uses it for bad things, a bit like every James Bond baddie." Meanwhile, Luke Skywalker and the rest of the light side of the Force are seen living in "exaggerated domesticity" as they sit around drinking blue milk, surrounded by creatures. "There's a care and a weirdness to their architecture, plus it's loaded with color," says Reat, who adds that these choices help to make those characters more appealing and relatable.... The San Francisco International Airport also played a key role in the making of "Phantom Menace." A tour of its maintenance bay gave the film's creative designers a jolt of inspiration when they were creating Anakin's podracer and other vehicles. The article also adds that the inspiration for the Theed Royal Palace on Naboo in The Phantom Menace was "the Marin County Civic Center, where Lucas once served jury duty."

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Science Alert reports that a team of researchers found "that changes in glucose metabolism could help cancer grow by temporarily disabling a gene that protects us from tumors called BRCA2." The team first examined people who inherited one faulty copy of BRCA2. They found that cells from these people were more sensitive to methylglyoxal (MGO), which is produced when cells break down glucose for energy in the process of glycolysis. Glycolysis generates over 90 percent of the MGO in cells, which a pair of enzymes typically keep to minimal levels. In the event they can't keep up, high MGO levels can lead to the formation of harmful compounds that damage DNA and proteins. In conditions like diabetes, where MGO levels are elevated due to high blood sugar, these harmful compounds contribute to disease complications. The researchers discovered that MGO can temporarily disable the tumor-suppressing functions of the BRCA2 protein, resulting in mutations linked to cancer development... As the BRCA2 allele isn't permanently inactivated, functional forms of the protein it produces can later return to normal levels. But cells repeatedly exposed to MGO may continue to accumulate cancer-causing mutations whenever existing BRCA2 protein production fails. Overall, this suggests that changes in glucose metabolism can disrupt BRCA2 function via MGO, contributing to the development and progression of cancer... This new information may lead to strategies for cancer prevention or early detection. "Methylglyoxal can be easily detected by a blood test for HbA1C, which could potentially be used as a marker," Venkitaraman says. "Furthermore, high methylglyoxal levels can usually be controlled with medicines and a good diet, creating avenues for proactive measures against the initiation of cancer." Their research has been published in Cell.

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From the Washington Post's "Technology 202" newsletter: As tech giants move toward a world in which chatbots supplement, and perhaps supplant, search engines, the Microsoft executive assigned to make sure AI is used responsibly said the industry has to be careful not to break the business model of the wider web. Search engines citing and linking to the websites they draw from is "part of the core bargain of search," [Microsoft's chief Responsible AI officer] said in an interview Monday.... "It's really important to maintain a healthy information ecosystem and recognize it is an ecosystem. And so part of what I will continue to guide our Microsoft teams toward is making sure that we are citing back to the core webpages from which the content is sourced. Making sure that we've got that feedback loop happening. Because that is part of the core bargain of search, right? And I think it's critical to make sure that we are both providing users with new engaging ways to interact, to explore new ideas — but also making sure that we are building and supporting the great work of our creators." Asked about lawsuits alleging copyright use without permission, they said "We believe that there are strong grounds under existing laws to train models." But they also added those lawsuits are "asking legitimate questions" about where the boundaries are, "for which the courts will provide answers in due course."

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An anonymous reader shared this report from the Wall Street Journal: Drunken-driving deaths in the U.S. have risen to levels not seen in nearly two decades, federal data show, a major setback to long-running road-safety efforts. At the same time, arrests for driving under the influence have plummeted, as police grapple with challenges like hiring woes and heightened concern around traffic stops... About 13,500 people died in alcohol impairment-related crashes in 2022, according to data released in April by the National Highway Traffic Safety Administration. That is 33% above 2019's toll and on par with 2021's. The last time so many people died as a result of accidents involving intoxicated drivers was in 2006. That's still down from the early 1980s, when America was seeing over 20,000 drunk-driving deaths a year, according to the article. "By 2010, that number had fallen to around 10,000 thanks to high-profile public-education campaigns by groups like MADD, tougher laws, and aggressive enforcement that included sobriety checkpoints and typically yielded well over a million DUI arrests annually." But some hope to solve the problem using technology: Many activists and policymakers are banking on the promise of built-in devices to prevent a car from starting if the driver is intoxicated, either by analyzing a driver's exhaled breath or using skin sensors to gauge the blood-alcohol level. NHTSA issued a notice in December that it said lays the groundwork for potential alcohol-impairment detection technology standards in all new cars "when the technology is mature." And Glenn Davis, who manages Colorado's highway-safety office, "pointed to Colorado's extensive use of ignition interlock systems that require people convicted of DUI to blow into a tube to verify they are sober in order for their car to start. He said the office promotes nondriving options such as Lyft and Uber."

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