Scientists at the Indian Institute of Technology, Madras (IIT-M) have created what they describe as the world's most detailed 3D cellular atlas of the human brainstem, linking whole-brain MRI views to individual neurons across more than 500 tissue sections. The free online atlas, called Anchor, could help researchers better understand diseases such as Alzheimer's, Parkinson's, stroke, and SIDS by showing how healthy and diseased brain tissue differs cell by cell. The BBC reports: Built from high-resolution microscope images rather than costlier molecular techniques, it creates a detailed three-dimensional map of the brainstem, identifying more than 200 clusters of brain cells and nerve pathways. Eight chemical markers help distinguish different cell types, producing one of the clearest pictures yet of this vital, but poorly, understood part of the brain. The brainstem occupies only a sliver of the brain, yet it keeps people alive. It links the brain to the spinal cord and controls breathing, heartbeat, sleep, wakefulness and movement. [...] Users can zoom from the whole brainstem seen on MRI down to individual neurons while maintaining their precise spatial relationships. The researchers have made the atlas freely available online, hoping it becomes a reference tool for neuroscientists, neurologists and neurosurgeons worldwide. Its applications could also extend well beyond anatomy. By comparing healthy brainstem maps with diseased tissue, scientists may better understand disorders ranging from Parkinson's disease and stroke to Alzheimer's disease and sudden infant death syndrome (SIDS). More precise maps could also help neurosurgeons navigate one of the brain's most delicate regions with greater confidence.

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A new study suggests multilingualism may slow brain aging, with bilingual people showing brains that appear about six years younger than monolingual speakers and people who speak four languages showing brains that appear up to 13 years younger. Researchers say earlier language learning and higher proficiency appear to strengthen the effect. The Guardian reports: Our brains are made up of billions of nerve cells that communicate with one another. But as we get older, the connectivity in our brains often deteriorates, causing memory and speed of thought to decline. While previous research had observed that people from European countries with greater language proficiency tended to age more slowly, this study measured the impact of speaking languages on individual brains. Scientists in Spain, Chile, Argentina and Dublin compared people living in the Basque region -- characterized by high levels of multilingualism -- who spoke Spanish, Basque, French and/or English. To measure neurological age, the scientists used magnetoencephalography to measure the brain activity of 728 people with varying ages and levels of linguistic ability. They then used AI to process the results to calculate a normal level of brain connectivity at any given age. A second unrelated group of 144 people were then scanned and compared, comprising equal numbers of people speaking one, two, three or four languages. Dr Lucia Amoruso, from the Basque Center on Cognition, Brain and Language in San Sebastian, said: "In simple terms, people who spoke more languages tended to have brains that looked younger than expected for their chronological age. The effect was not only related to the number of languages spoken. Higher language proficiency and earlier acquisition of a second language were also associated with more delayed brain ageing. This suggests that multilingual experience matters as a gradient: it is not simply about being bilingual or not, but about the depth and duration of language experience."

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