A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN: With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine. The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the "bad" cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease. "We hope this is a permanent solution, where younger people with severe disease can undergo a 'one and done' gene therapy and have reduced LDL and triglycerides for the rest of their lives," said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio.... Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston... People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. "It's a naturally occurring mutation that's protective against cardiovascular disease," said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. "And now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection." "Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said." And CNN quotes Nissen as saying "We hope to do all this by the end of next year. We're moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason."

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A former Business Analyst reportedly filed a class action lawsuit claiming that for years, hundreds of remote employees at Bank of America first had to boot up complex computer systems before their paid work began, reports Human Resources Director magazine: Tava Martin, who worked both remotely and at the company's Jacksonville facility, says the financial institution required her and fellow hourly workers to log into multiple security systems, download spreadsheets, and connect to virtual private networks — all before the clock started ticking on their workday. The process wasn't quick. According to the filing in the United States District Court for the Western District of North Carolina, employees needed 15 to 30 minutes each morning just to get their systems running. When technical problems occurred, it took even longer... Workers turned on their computers, waited for Windows to load, grabbed their cell phones to request a security token for the company's VPN, waited for that token to arrive, logged into the network, opened required web applications with separate passwords, and downloaded the Excel files they needed for the day. Only then could they start taking calls from business customers about regulatory reporting requirements... The unpaid work didn't stop at startup. During unpaid lunch breaks, many systems would automatically disconnect or otherwise lose connection, forcing employees to repeat portions of the login process — approximately three to five minutes of uncompensated time on most days, sometimes longer when a complete reboot was required. After shifts ended, workers had to log out of all programs and shut down their computers securely, adding another two to three minutes. Thanks to Slashdot reader Joe_Dragon for sharing the article.

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The Associated Press reports that "For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — 'to cure, prevent or manage all disease' — if not in their lifetime, then in their children's." During that decade they also funded other initiatives (including underprivileged schools and immigration reform), according to the article. But there's a change coming: Now, the billionaire couple is shifting the bulk of their philanthropic resources to Biohub, the pair's science organization, and focusing on using artificial intelligence to accelerate scientific discovery. The idea is to develop virtual, AI-based cell models to understand how they work in the human body, study inflammation and use AI to "harness the immune system" for disease detection, prevention and treatment. "I feel like the science work that we've done, the Biohub model in particular, has been the most impactful thing that we have done. So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward," Zuckerberg said Wednesday evening at an event at the Biohub Imaging Institute in Redwood City, California.... Chan and Zuckerberg have pledged 99% of their lifetime wealth — from shares of Meta Platforms, where Zuckerberg is CEO — toward these efforts... On Thursday, Chan and Zuckerberg also announced that Biohub has hired the team at EvolutionaryScale, an AI research lab that has created large-scale AI systems for the life sciences... Biohub's ambition for the next years and decades is to create virtual cell systems that would not have been possible without recent advances in AI. Similar to how large language models learn from vast databases of digital books, online writings and other media, its researchers and scientists are working toward building virtual systems that serve as digital representations of human physiology on all levels, such as molecular, cellular or genome. As it is open source — free and publicly available — scientists can then conduct virtual experiments on a scale not possible in physical laboratories. "We will continue the model we've pioneered of bringing together scientists and engineers in our own state-of-the-art labs to build tools that advance the field," according to Thursday's blog post. "We'll then use those tools to generate new data sets for training new biological AI models to create virtual cells and immune systems and engineer our cells to detect and treat disease.... "We have also established the first large-scale GPU cluster for biological research, as well as the largest datasets around human cell types. This collection of resources does not exist anywhere else."

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Merged today ahead of the Linux 6.18-rc5 kernel due out on Sunday is a partial fix for a performance regression observed on IBM POWER hardware...

Long-time Slashdot reader AmiMoJo shared this report from Marine Insight: The world's largest cargo sailboat, Neoliner Origin, completed its first transatlantic voyage on 30 October despite damage to one of its sails during the journey. The 136-metre-long vessel had to rely partly on its auxiliary motor and its remaining sail after the aft sail was damaged in a storm shortly after departure... Neoline, the company behind the project, said the damage reduced the vessel's ability to perform fully on wind power... The Neoliner Origin is designed to reduce greenhouse gas emissions by 80 to 90 percent compared to conventional diesel-powered cargo ships. According to the United Nations Conference on Trade and Development (UNCTAD), global shipping produces about 3 percent of worldwide greenhouse gas emissions... The ship can carry up to 5,300 tonnes of cargo, including containers, vehicles, machinery, and specialised goods. It arrived in Baltimore carrying Renault vehicles, French liqueurs, machinery, and other products. The Neoliner Origin is scheduled to make monthly voyages between Europe and North America, maintaining a commercial cruising speed of around 11 knots.

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"Internal documents have revealed that Meta has projected it earns billions from ignoring scam ads that its platforms then targeted to users most likely to click on them," writes Ars Technica, citing a lengthy report from Reuters. Reuters reports that Meta "for at least three years failed to identify and stop an avalanche of ads that exposed Facebook, Instagram and WhatsApp's billions of users to fraudulent e-commerce and investment schemes, illegal online casinos, and the sale of banned medical products..." On average, one December 2024 document notes, the company shows its platforms' users an estimated 15 billion "higher risk" scam advertisements — those that show clear signs of being fraudulent — every day. Meta earns about $7 billion in annualized revenue from this category of scam ads each year, another late 2024 document states. Much of the fraud came from marketers acting suspiciously enough to be flagged by Meta's internal warning systems. But the company only bans advertisers if its automated systems predict the marketers are at least 95% certain to be committing fraud, the documents show. If the company is less certain — but still believes the advertiser is a likely scammer — Meta charges higher ad rates as a penalty, according to the documents. The idea is to dissuade suspect advertisers from placing ads. The documents further note that users who click on scam ads are likely to see more of them because of Meta's ad-personalization system, which tries to deliver ads based on a user's interests... The documents indicate that Meta's own research suggests its products have become a pillar of the global fraud economy. A May 2025 presentation by its safety staff estimated that the company's platforms were involved in a third of all successful scams in the U.S. Meta also acknowledged in other internal documents that some of its main competitors were doing a better job at weeding out fraud on their platforms... The documents note that Meta plans to try to cut the share of Facebook and Instagram revenue derived from scam ads. In the meantime, Meta has internally acknowledged that regulatory fines for scam ads are certain, and anticipates penalties of up to $1 billion, according to one internal document. But those fines would be much smaller than Meta's revenue from scam ads, a separate document from November 2024 states. Every six months, Meta earns $3.5 billion from just the portion of scam ads that "present higher legal risk," the document says, such as those falsely claiming to represent a consumer brand or public figure or demonstrating other signs of deceit. That figure almost certainly exceeds "the cost of any regulatory settlement involving scam ads...." A planning document for the first half of 2023 notes that everyone who worked on the team handling advertiser concerns about brand-rights issues had been laid off. The company was also devoting resources so heavily to virtual reality and AI that safety staffers were ordered to restrict their use of Meta's computing resources. They were instructed merely to "keep the lights on...." Meta also was ignoring the vast majority of user reports of scams, a document from 2023 indicates. By that year, safety staffers estimated that Facebook and Instagram users each week were filing about 100,000 valid reports of fraudsters messaging them, the document says. But Meta ignored or incorrectly rejected 96% of them. Meta's safety staff resolved to do better. In the future, the company hoped to dismiss no more than 75% of valid scam reports, according to another 2023 document. A small advertiser would have to get flagged for promoting financial fraud at least eight times before Meta blocked it, a 2024 document states. Some bigger spenders — known as "High Value Accounts" — could accrue more than 500 strikes without Meta shutting them down, other documents say. Thanks to long-time Slashdot reader schwit1 for sharing the article.

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Long-time Slashdot reader AmiMoJo shared this report from Linuxiac: The Japanese branch of Mozilla's Support Mozilla (SUMO) community — responsible for localizing and maintaining Japanese-language support documentation for Firefox and other Mozilla products (consisting of Japanese native speakers) — has officially disbanded after more than two decades of voluntary work... SUMO, short for Support Mozilla, is the umbrella project for Mozilla's user support platform, support.mozilla.org, that brings together volunteers and contributors worldwide who translate, maintain, and update documentation, tutorials, and troubleshooting guides for Firefox, Thunderbird, and other Mozilla products... According to marsf, the long-time locale leader of the Japanese SUMO team, the decision to disband was triggered by the recent introduction of an automated translation system known as Sumobot. Deployed on October 22, the bot began editing and approving Japanese Knowledge Base articles without community oversight. The article notes marsf's complaints in a post to the SUMO discussion forum, including the fact that the new automated system automatically approved machine-translated content with only a 72-hour window for human review. As a result, more than 300 Knowledge Base articles were overwritten on the production server, which marsf called "mass destruction of our work."

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American multinational freight company UPS "has grounded its fleet of MD-11 aircraft," reports the Guardian, "days after a cargo plane crash that killed at least 13 people in Kentucky. The grounded MD-11s are the same type of plane involved in Tuesday's crash in Louisville. They were originally built by McDonnell Douglas until it was taken over by Boeing." More details from NBC News: UPS said the move to temporarily ground its MD-11 fleet was made "out of an abundance of caution and in the interest of safety." MD-11s make up 9% of the company's air fleet, it said. "We made this decision proactively at the recommendation of the aircraft manufacturer. Nothing is more important to us than the safety of our employees and the communities we serve," UPS spokesman Jim Mayer said... FedEx said early Saturday that it was also grounding its MD-11s. The UPS rival has 28 such planes in operation, out of a fleet of around 700, FedEx said. Video shows that the left engine of the plane caught fire during takeoff and immediately detached, National Transportation Safety Board member Todd Inman said Wednesday. The National Transportation Safety Board is the lead agency in the investigation. Thanks to long-time Slashdot reader echo123 for suggesting the article.

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Ryzen AI Software as AMD's collection of tools and libraries for AI inferencing on AMD Ryzen AI class PCs has Linux support with its newest point release. Though this "early access" Linux support is restricted to registered AMD customers...

"Maybe you've heard that artificial intelligence is a bubble poised to burst," writes a Washington Post technology columnist. "Maybe you have heard that it isn't. (No one really knows either way, but that won't stop the bros from jabbering about it constantly.)" "But I can confidently tell you that the money being thrown around for AI is so huge that numbers have lost all meaning." The companies pouring money in are so rich and so power-hungry (in multiple meanings of that term) that our puny human brains cannot really comprehend. So let's try to give some meaning and context to the stratospheric numbers in AI. Is it a bubble? Eh, who knows. But it is completely bonkers. In just the past year, the four richest companies developing AI — Microsoft, Google, Amazon and Meta — have spent roughly $360 billion combined for big-ticket projects, which included building AI data centers and stuffing them with computer chips and equipment, according to my analysis of financial disclosures.... How do companies pay for the enormous sums they are lavishing on AI? Mostly, these companies make so much money that they can afford to go bananas... Eight of the world's top 10 most valuable companies are AI-centric or AI-ish American corporate giants — Nvidia, Apple, Microsoft, Google, Amazon, Broadcom, Meta and Tesla. That's according to tallies from S&P Global Market Intelligence based on the total price of the companies' stock held by investors. My analysis of the S&P data shows that the collective worth of those eight giants, $23 trillion, is more than the value of the next 96 most valuable U.S. companies put together, which includes many still very rich names such as JPMorgan, Walmart, Visa and ExxonMobil. No. 1 on that list, the AI computer chip seller Nvidia, last week become the first company in history to reach a stock market value of $5 trillion. That alone was more than the value of entire stock markets in most countries, Bloomberg News reported, other than the five biggest (in the U.S., China, Japan, Hong Kong and India)... All the announced or under-construction data centers for powering AI would consume roughly as much electricity as 44 million households in the United States if they run full tilt, according to a recent analysis by the Barclays investment bank as reported by the Financial Times. For context, that's nearly one-third of the total number of residential housing units in the entire country, according to U.S. Census Bureau housing estimates for 2024.

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AMD has begun their open-source compiler enablement upstreaming effort for Zen 6 processors! The first "Znver6" patch was sent out on Friday in preparing for new instructions to be found with these next-generation AMD Ryzen and EPYC processors...

Released one Friday was the newest version of oneDNN as this library started off by Intel and now officially under the UXL Foundation umbrella for serving as building blocks for deep learning software...

An anonymous reader quotes a report from the New York Times: Facebook Dating, which debuted in 2019, has become a surprise hit for the company. It lets people create a dating profile free in the app, where they can swipe and match with other eligible singles. It has more than 21 million daily users, quietly making it one of the most popular online dating services. Hinge, a leading dating app in the United States, has around 15 million users. "Underlying it all is that there are real people on Facebook," Tom Alison, the head of Facebook, said in an interview. "You can see who they are, you can see how you're connected to them, and if you have mutual friends, we make it easy to see where you have mutual interests." Facebook Dating's popularity is a sign of how Facebook has been reinventing itself. One of the early social networks, its main social feed has become less popular over time than younger apps like Instagram and TikTok. But along with Facebook Marketplace, where people look for deals on things like couches and used cars, Facebook Dating shows how an older social network can remain relevant. "When you look at Gen Z usage on Facebook, they aren't using the social media feed," said Mike Proulx, a research director at Forrester VP, a research firm. "What's bringing them back to the platform is Marketplace, Messenger, Dating."

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Tribune — Bon oui, votre premier réflexe sera sans doute de vous, ou de nous demander « mais WTF, qui achète un graveur de DVD en 2025 ? » Manifestement il y a encore des adeptes des supports optiques à durée de vie limitée. Il faut avouer que cette délicieuse anachronie technologique, ce fossile vivant du digital qui s'accroche tel Sisyphe à son rocher dans un monde de streaming ubiquitaire, c'est un peu le vinyle du pauvre, l'adepte de l'économie parallèle du DVD d'occasion à 2 €... [Tout lire]

The Qt toolkit has merged support for Wayland's color-management-v1 protocol to replace the former xx-color-management-v4 protocol shipped by this open-source toolkit. The change was merged for Qt 6.11 development but also back-ported for the Qt 6.10 series...

On ACPI-enabled systems Linux users can enjoy PCIe M.2 connected peripherals that "just work" without any extra fuss. But for those relying on Device Tree (DT) handling by the kernel, new patches from Qualcomm are working on representing PCIe M.2 connectors within DT files...