Doug Whitney carries a genetic mutation that guaranteed he would develop Alzheimer's disease in his late forties or early fifties. His mother and nine of her thirteen siblings died from the disease. His oldest brother died at 45. The mutation has decimated his family for generations. Whitney is now 76 and remains cognitively healthy. The New York Times has a fascinating long read on Whitney and things happening around him. Scientists at Washington University School of Medicine in St. Louis have studied Whitney for 14 years. They extract his cerebrospinal fluid and conduct brain scans during his periodic visits from Washington State. His brain contains heavy amyloid deposits but almost no tau tangles in regions associated with dementia. Tau accumulation correlates directly with cognitive decline. Whitney accumulated tau only in his left occipital lobe, an area that does not play a major role in Alzheimer's. Researchers identified several possibly protective factors in Whitney's biology. His immune system produces a lower inflammatory response than other mutation carriers. He has unusually high levels of heat shock proteins, which prevent proteins from misfolding. Scientists believe his decade working in Navy engine rooms at temperatures reaching 110 degrees may have driven this accumulation. He also carries three gene variants his afflicted relatives lack. His son Brian inherited the mutation and remains asymptomatic at 43. Brian received anti-amyloid drugs in clinical trials. Researchers published their findings on Whitney in Nature Medicine. They described the study as a call for other scientists to help solve the case.

Read more of this story at Slashdot.

eBird, now the world's largest citizen science project with over 2 billion bird observations, is transforming ornithology by turning casual birders (and even TikTok-using kids) into vital contributors to global research and conservation. Slashdot reader alternative_right shares a report from Phys.org: The Cornell Lab of Ornithology has been one of the most influential organizations in the world when it comes to encouraging people to engage in natural history projects. While some form of amateur involvement in science projects has been around since 1900, when the Audubon Society organized the first Christmas Bird Count, it was the Cornell Lab that formalized citizen science as a sound and reliable means of collecting data on birds. It didn't take much thought to realize that one of the richest sources of information about birds resided in the notebooks virtually every birder has kept, often from childhood. It's a given that birdwatchers list everything. The problem is that zillions of such notebooks sit forgotten in drawers or in dusty boxes in the attic. If only all of that information could be gathered together, organized in sensible ways and then made available to anyone who wanted to use it. What a resource that would be! After lots of trials and discussion, a small team at the Lab came up with the idea of eBird. It started in a humble way back in 2002, as simply somewhere birders could store their records in a central location. Today, "humble" is no longer an appropriate description. In 2022, its 20th anniversary year, a total of more than 1.3 billion records had been received from more than 820,000 participants. In the month of August this year, reports eBird, 123,000 birders submitted 1.6 million lists of sightings. It has now hit a total of 2 billion bird observations since inception.

Read more of this story at Slashdot.

Susumu Kitagawa, Richard Robson, and Omar M. Yaghi were awarded the Nobel Prize in Chemistry on Wednesday for the development of molecular building blocks with spaces large enough that gases and other chemicals can flow through them. The New York Times: The cavities on the inside are "almost like rooms in a hotel, so that guest molecules can enter and also exit again from the same material," Heiner Linke, chair of the Nobel Committee for Chemistry, said during the announcement of the award. The laureates' discoveries, he added, pave the way for the creation of materials that can separate toxic chemicals from wastewater or harvest water molecules in a desert. The laureates' work started with experiments by Dr. Robson in the 1980s and gradually developed over a period of about 15 years. "It takes time for science to be recognized, and it takes multiple workers in the field with different approaches," said Dorothy Phillips, president of the American Chemical Society. The three laureates will share a prize of 11 million Swedish kronor, or around $1.17 million.

Read more of this story at Slashdot.

The New York Times: John Clarke, Michel H. Devoret and John M. Martinis were awarded the Nobel Prize in Physics on Tuesday in Sweden for showing that two properties of quantum mechanics, the physical laws that rule the subatomic realm, could be observed on a system large enough to see with the naked eye. They will share a prize of 11 million Swedish kroner, or around $1.17 million. "There is no advanced technology today that does not rely on quantum mechanics," Olle Eriksson, chairman of the Nobel Committee for Physics, said during the announcement of the award. The laureates' discoveries, he added, paved the way for technologies like the cellphone, cameras and fiber optic cables. It also helped lay the groundwork for current attempts to build a quantum computer, a device that could compute and process information at speeds that would not be possible with classical computer. Martinis worked at Google from 2014 to 2020 to build a quantum computer and led the quantum supremacy experiment in 2019. Devoret is cited in Google's recent breakthrough where its Willow quantum chip solved a problem in five minutes that the world's most advanced supercomputer could never solve. The three laureates conducted experiments with electrical circuits that demonstrated quantum mechanical tunneling and quantized energy levels in systems large enough to hold in the hand. Clarke is a professor at the University of California, Berkeley. Devoret joined his research group in the 1980s and is now at Yale University and UC Santa Barbara. Martinis also joined the group in the 1980s and is currently at UC Santa Barbara and co-founded Qolab, a startup developing utility-scale superconducting quantum computers.

Read more of this story at Slashdot.

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi received the Nobel Prize in Physiology or Medicine on Monday for their discoveries about how the immune system regulates itself. The three researchers split 11 million Swedish kroner ($1.17 million). Their work identified regulatory T cells and the FOXP3 gene that controls them. Dr. Sakaguchi spent more than a decade solving a puzzle about the thymus. He discovered that the immune system has a backup mechanism to stop harmful cells from attacking the body's own tissues. Dr. Brunkow and Dr. Ramsdell found the specific gene responsible for this process while studying mice that developed severe autoimmune disease. More than 200 clinical trials are now underway based on their research. Cancers attract regulatory T cells to block immune attacks. Researchers are developing drugs to turn the immune system against these cancer cells. In autoimmune diseases, regulatory T cells are missing or defective. The FOXP3 gene provides a starting point for drugs that teach the immune system to stop attacking itself.

Read more of this story at Slashdot.

An anonymous reader shared this report from the Washington Post: Women tend to live longer than men. There are traditional explanations: Men smoke more. They drink more. They tend to engage in riskier behavior. But the fact that this lifespan gap holds true regardless of country or century indicates something deeper is also at play. A growing body of evidence suggests that women's relative longevity may derive, in part, from having double X chromosomes, a redundancy that protects them against harmful mutations. That theory was further bolstered Wednesday with the publication of the most sweeping analysis to date of the lifespan differences between males and females in more than 1,000 mammal and bird species... If a baby has a pair of X chromosomes, she's a girl. If the baby inherits an X chromosome and a Y chromosome, he's a boy. In birds, however, the situation is reversed. Female birds have a pair of unlike sex chromosomes while males have the like pair... For their study, Colchero, Staerk and their colleagues collected data on the lifespans of 528 mammal species and 648 bird species kept in zoos. The team found that most other mammals are like humans, with the females of nearly three-fourths of mammal species outliving their male counterparts. But in birds, 68 percent of species studied showed a bias toward male longevity, as expected from their chromosomal makeup.

Read more of this story at Slashdot.

Jane Goodall, world-renowned primatologist, anthropologist, and conservationist, has died at the age of 91 while on a speaking tour in California. The British primatologist's "discoveries as an ethologist revolutionized science, and she was a tireless advocate for the protection and restoration of our natural world," according to the institute she founded. From a report: Goodall was only 26 years old when she first traveled to Tanzania and began her important research on chimpanzees in the wild. Throughout her study of the species, Goodall proved that primates display an array of similar behaviors to humans, such as the ability to develop individual personalities and make and use their own tools. Among the most surprising discoveries Goodall made was "how like us" the chimpanzees are, she told ABC News in 2020. "Their behavior, with their gestures, kissing, embracing, holding hands and patting on the back," she said. "... The fact that they can actually be violent and brutal and have a kind of war, but also loving an altruistic." That discovery is considered one of the great achievements of 20th-century scholarship, according to the Jane Goodall Institute. [...] Goodall's research garnered both scientific honors and mainstream fame, and she was credited with paving the way for a rise in women pursuing careers in STEM (science, technology, engineering and math) over the years. The number of women in STEM has increased from 7% to 26% in the six last decades, according to The Jane Goodall Institute, which cited census information from 1970 to 2011. In 1991, she also founded Roots & Shoots, a global humanitarian and environmental program for young people. She was named a United Nations Messenger of Peace in April 2002. The anthropologist continued to lend her voice to environmental causes well into her 80s and 90s. In 2019, Goodall acknowledged the climate crisis and the importance of mitigating further warming, telling ABC News that the planet is "imperiled." "We are definitely at a point where we need to make something happen," she said. "We are imperiled. We have a window of time. I'm fairly sure we do. But, we've got to take action." Goodall even partnered with Apple in 2022 to encourage customers to recycle their devices to reduce individual carbon footprint and cut down on unnecessary mineral mining around the world. "Yes, people need to make money, but it is possible to make money without destroying the planet," Goodall told ABC News at the time. "We've gone so far in destroying the planet that it's shocking."

Read more of this story at Slashdot.

An anonymous reader quotes a report from the BBC: US scientists have, for the first time, made early-stage human embryos by manipulating DNA taken from people's skin cells and then fertilizing it with sperm. The technique could overcome infertility due to old age or disease, by using almost any cell in the body as the starting point for life. It could even allow same-sex couples to have a genetically related child. [...] The Oregon Health and Science University research team's technique takes the nucleus -- which houses a copy of the entire genetic code needed to build the body -- out of a skin cell. This is then placed inside a donor egg that has been stripped of its genetic instructions. So far, the technique is like the one used to create Dolly the Sheep -- the world's first cloned mammal -- born back in 1996. However, this egg is not ready to be fertilized by sperm as it already contains a full suite of chromosomes. You inherit 23 of these bundles of DNA from each of your parents for a total of 46, which the egg already has. So the next stage is to persuade the egg to discard half of its chromosomes in a process the researchers have termed "mitomeiosis" (the word is a fusion of mitosis and meiosis, the two ways cells divide). The study, published in the journal Nature Communications, showed 82 functional eggs were made. These were fertilized with sperm and some progressed onto the early stages of embryos development. None were developed beyond the six-day-stage. The technique is far from polished as the egg randomly chooses which chromosomes to discard. It needs to end up with one of each of the 23 types to prevent disease, but ends up with two of some and none of others. There is also a poor success rate (around 9%) and the chromosomes miss an important process where they rearrange their DNA, called crossing over. Prof Mitalipov, a world-renowned pioneer in the field, told me: "We have to perfect it. "Eventually, I think that's where the future will go because there are more and more patients that cannot have children."

Read more of this story at Slashdot.

Étonnant... et toujours pas expliqué scientifiquement.
(Permalink)

A review of 62 scientific studies published in Osteoporosis International found that microplastics weaken bones by disrupting bone marrow stem cells and stimulating osteoclasts, cells that degrade bone tissue. Laboratory experiments found the particles reduce cell viability, induce premature cellular aging, modify gene expression, and trigger inflammatory responses. Animal studies found microplastic accumulation decreases white blood cell counts and deteriorates bone microstructure, creating irregular cell structures that increase fracture risk. Rodrigo Bueno de Oliveira from the State University of Campinas in Brazil said the effects interrupted skeletal growth in test animals.

Read more of this story at Slashdot.

"The internet is full of people claiming to uncover conspiracies in politics and business..." reports the Wall Street Journal. "Now an unlikely new villain has been added to the list: theoretical physicists," they write, saygin resentment of scientific authority figures "is the major attraction of what might be called 'conspiracy physics'." In recent years, a group of YouTubers and podcasters have attracted millions of viewers by proclaiming that physics is in crisis. The field, they argue, has discovered little of importance in the last 50 years, because it is dominated by groupthink and silences anyone who dares to dissent from mainstream ideas, like string theory... Most fringe theories are too arcane for listeners to understand, but anyone can grasp the idea that academic physics is just one more corrupt and self-serving establishment... In this corner of the internet, the scientist Scott Aaronson has written, "Anyone perceived as the 'mainstream establishment' faces a near-insurmountable burden of proof, while anyone perceived as 'renegade' wins by default if they identify any hole whatsoever in mainstream understanding... As with other kinds of authorities, there are reasonable criticisms to be made of academic physics. By some metrics, scientific productivity has slowed since the 1970s. String theory has not fulfilled physicists' early dreams that it would become the ultimate explanation of all forces and matter in our universe. The Large Hadron Collider, the world's largest particle accelerator, has delivered fewer breakthroughs than scientists expected when it turned on in 2010. But even reasonable points become hard to recognize when expressed in the ways YouTube incentivizes. Conspiracy physics videos with titles like "They Just Keep Lying" are full of sour sarcasm, outraged facial expressions and spooky music... Leonard Susskind, director of the Stanford Institute for Theoretical Physics, says physicists need to be both more sober and more forceful when addressing the public. The limits of string theory should be acknowledged, he says, but the idea that progress has slowed isn't right. In the last few decades, he and other physicists have figured out how to make progress on the vast project of integrating general relativity and quantum mechanics, the century-old pillars of physics, into a single explanation of the universe. The bitter attacks on leading physicists get a succinct summary in the article from Chris Williamson, a "Love Island" contestant turned podcast host. "This is like 'The Kardashians' for physicists — I love it."

Read more of this story at Slashdot.

The BBC reports that a million-year-old human skull found in China suggests that the human species "began to emerge at least half a million years earlier than we thought, researchers are claiming in a new study." It also shows that we co-existed with other sister species, including Neanderthals, for much longer than we've come to believe, they say. The scientists claim their analysis "totally changes" our understanding of human evolution and, if correct, it would certainly rewrite a key early chapter in our history. But other experts in a field where disagreement over our emergence on the planet is rife, say that the new study's conclusions are plausible but far from certain. The discovery, published in the leading scientific journal Science, shocked the research team, which included scientists from a university in China and the UK's Natural History Museum. "From the very beginning, when we got the result, we thought it was unbelievable. How could that be so deep into the past?" said Prof Xijun Ni of Fudan University, who co-led the analysis. "But we tested it again and again to test all the models, use all the methods, and we are now confident about the result, and we're actually very excited." Thanks to long-time Slashdot reader sinij for sharing the article.

Read more of this story at Slashdot.

Doctors report the first successful treatment for Huntington's disease using a new type of gene therapy given during 12 to 18 hours of delicate brain surgery. The BBC reports: An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients. It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of "good quality life", Prof Sarah Tabrizi told BBC News. The first symptoms of Huntington's disease tend to appear in your 30s or 40s and is normally fatal within two decades -- opening the possibility that earlier treatment could prevent symptoms from ever emerging. None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair. Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families. [...] It starts with a safe virus that has been altered to contain a specially designed sequence of DNA. This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions - the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery. The virus then acts like a microscopic postman -- delivering the new piece of DNA inside brain cells, where it becomes active. This turns the neurons into a factory for making the therapy to avert their own death. The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells' DNA for building mutant huntingtin. This results in lower levels of mutant huntingtin in the brain. [...] The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life. The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid -- a clear sign of brain cells dying -- should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.

Read more of this story at Slashdot.

alternative_right shares a report from ScienceDaily: Scientists have developed a new multi-layered metalens design that could revolutionize portable optics in devices like phones, drones, and satellites. By stacking metamaterial layers instead of relying on a single one, the team overcame fundamental limits in focusing multiple wavelengths of light. Their algorithm-driven approach produced intricate nanostructures shaped like clovers, propellers, and squares, enabling improved performance, scalability, and polarization independence. [...] Mr Joshua Jordaan, from the Research School of Physics at the Australian National University and the ARC Centre of Excellence for Transformative Meta-Optical Systems (TMOS), said the ability to make metalenses to collect a lot of light will be a boon for future portable imaging systems. "The metalenses we have designed would be ideal for drones or earth-observation satellites, as we've tried to make them as small and light as possible," he said. The findings have been published in the journal Optics Express.

Read more of this story at Slashdot.

Micro- and nanoplastic particles "infiltrate all systems of the body, including the brain," notes the University of Rhode Island, "where they can accumulate and trigger Alzheimer's-like conditions, according to a new study by researchers in the University of Rhode Island College of Pharmacy." ScienceDaily shares the announcement: After a previous study that showed how microplastics can infiltrate all systems of the body — including the blood-brain barrier, which protects the brain from harmful substances as small as viruses and bacteria — University of Rhode Island pharmacy assistant professor Jaime Ross expanded the study to determine the brain health impacts of the plastic toxins. Her findings indicate that the accumulation of micro- and nanoplastics in the brain can lead to cognitive decline and even Alzheimer's disease, especially in those who carry genetic risk factors. Ross' latest study, published recently in the journal Environmental Research Communications, examined mice that had been genetically modified to include the naturally occurring gene APOE4, a strong indicator of Alzheimer's risk making people 3.5 times more likely to develop the disease than those who carry the APOE3 variant of the gene that is passed from parents to offspring... Ross and her team exposed two groups of mice — one with the APOE4 variant and one with APOE3 — to micro- and nanoplastics in their drinking water over a period of three weeks. The tiny particles from polystyrene — among the most abundant plastics in the world, found in Styrofoam take-out containers, plastic cups and more — infiltrated the mice' organs, including the brain, as expected... Ross' team then ran the mice through a series of tests to examine their cognitive ability, beginning with an open-field test, in which researchers put a mouse in a chamber and allow it to explore at will for 90 minutes. Ordinarily, a mouse will hug the walls, naturally attempting to hide from potential predators. However, after microplastic exposure, the APOE4 mice — especially the male mice — tended to wander more in the middle of the chamber and spend time in open space, leaving themselves vulnerable to predators... The results are concerning enough to warrant further study into the cognitive decline caused by exposure to micro- and nanoplastics, which are among the most prominent environmental toxins to which people are routinely exposed... Ross is continuing to expand her research into the topic and encourages others to do so, in the hope of leading to better regulation of the toxins.

Read more of this story at Slashdot.

Tiens les prix IgNobels sont sortis !

(Rappel : Ce prix récompense les recherches scientifiques les plus improbables. Par exemple une année, il y avait eu une étude scientifique sur la pression dans le sphincter des pingouins au moment où ils vont déféquer.)
(Permalink)

alternative_right shares a report from Phys.org: Scientists from Taiwan have developed a new material that can stretch up to 4,600% of its original length before breaking. Even if it does break, gently pressing the pieces together at room temperature allows it to heal, fully restoring its shape and stretchability within 10 minutes. The sticky and stretchy polyurethane (PU) organogels were designed by combining covalently linked cellulose nanocrystals (CNCs) and modified mechanically interlocked molecules (MIMs) that act as artificial molecular muscles. The muscles make the gel sensitive to external forces such as stretching or heat, where its color changes from orange to blue based on whether the material is at rest or stimulated. Thanks to these unique properties, the gels hold great promise for next-generation technologies -- from flexible electronic skins and soft robots to anti-counterfeiting solutions. The findings have been published in the journal Advanced Functional Materials.

Read more of this story at Slashdot.

"Phys.org is reporting on a study published in Nature Physics involving ICN2 at the UAB campus, Xi'an Jiaotong University (Xi'an) and Stony Brook University (New York), showing for the first time that ordinary ice is a flexoelectric material -- meaning it can generate electricity when subjected to mechanical deformation," writes longtime Slashdot reader fahrbot-bot. From the report: "We discovered that ice generates electric charge in response to mechanical stress at all temperatures. In addition, we identified a thin 'ferroelectric' layer at the surface at temperatures below -113C (160K)," explains Dr. Xin Wen, a member of the ICN2 Oxide Nanophysics Group and one of the study's lead researchers. "This means that the ice surface can develop a natural electric polarization, which can be reversed when an external electric field is applied -- similar to how the poles of a magnet can be flipped. The surface ferroelectricity is a cool discovery in its own right, as it means that ice may have not just one way to generate electricity, but two: ferroelectricity at very low temperatures, and flexoelectricity at higher temperatures all the way to 0 C." This property places ice on a par with electroceramic materials such as titanium dioxide, which are currently used in advanced technologies like sensors and capacitors.

Read more of this story at Slashdot.

Finland's second-largest university has announced new research suggesting that heart attacks could be an infectious disease. [T]he research found that, in coronary artery disease, atherosclerotic plaques containing cholesterol may harbor a gelatinous, asymptomatic biofilm formed by bacteria over years or even decades. Dormant bacteria within the biofilm remain shielded from both the patient's immune system and antibiotics because they cannot penetrate the biofilm matrix. A viral infection or another external trigger may activate the biofilm, leading to the proliferation of bacteria and an inflammatory response. The inflammation can cause a rupture in the fibrous cap of the plaque, resulting in thrombus [blood clot] formation and ultimately myocardial infarction... "Bacterial involvement in coronary artery disease has long been suspected, but direct and convincing evidence has been lacking," explains professor Pekka Karhunen [who led the study with researchers from the UK and Finland]. "Our study demonstrated the presence of genetic material — DNA — from several oral bacteria inside atherosclerotic plaques." The findings were validated by developing an antibody targeted at the discovered bacteria, which unexpectedly revealed biofilm structures in arterial tissue. Bacteria released from the biofilm were observed in cases of myocardial infarction. The body's immune system had responded to these bacteria, triggering inflammation which ruptured the cholesterol-laden plaque. The observations pave the way for the development of novel diagnostic and therapeutic strategies for myocardial infarction. Furthermore, they advance the possibility of preventing coronary artery disease and myocardial infarction by vaccination. "The research is part of an extensive EU-funded cardiovascular research project involving 11 countries..."

Read more of this story at Slashdot.

The Washington Post notes that past research "indicates that exercise helps some cancer survivors avoid recurrence of their disease." But a new study "offers an explanation of how, showing that exercise changes the inner workings of our muscles and cells, although more study is still needed..." The study, published last month, involved 32 women who'd survived breast cancer. After a single session of interval training or weightlifting, their blood contained higher levels of certain molecules, and those factors helped put the brakes on laboratory-grown breast cancer cells. "Our work shows that exercise can directly influence cancer biology, suppressing tumor growth through powerful molecular signals," said Robert Newton, the deputy director of the Exercise Medicine Research Institute at Edith Cowan University in Perth, Australia, and senior author of the new study. His group's experiment adds to mounting evidence that exercise upends the risks of not only developing but also surviving cancer... Scientists know contracting muscles release a slew of hormones and biochemicals, known as myokines, into our bloodstreams and have long suspected these myokines fight cancer. In some past studies with mice and healthy people, blood drawn after exercise and added to live cancer cells killed or suppressed the cancer's growth... [The new study tested cancer cells in high-tech petri dishes with blood drawn from cancer survivors.] Drenched in plasma from either the interval trainers or the lifters, many cancer cells quit growing. Quite a few died. (The blood drawn before exercise had no effects.) The cancer-fighting impacts were greatest with the blood drawn after interval training. Why? Additional testing showed this blood contained the highest concentrations of certain, beneficial myokines, especially IL-6, a protein that affects immune responses and inflammation... What these results mean, Newton said, is that "exercise doesn't just improve fitness and well-being" in people who've had cancer. "It also orchestrates a complex biological response that includes direct anticancer signals from muscles..." Questions remain, of course. Can any type of exercise fight cancer? Newton and other researchers have doubts. The exercise in this study was strenuous, by design. "Earlier studies suggested that the stronger the exercise stimulus, the greater the release of anticancer myokines," Newton said... Even the weight training in this study was less potent than the intense intervals. But Newton believes weight training remains key to cancer fighting. "People with cancer who increase their muscle mass through resistance training also experience greater rises in circulating myokines," he said. More muscle means more myokines.

Read more of this story at Slashdot.