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Hier — 27 mars 2024Flux principal

Two Nights of Broken Sleep Can Make People Feel Years Older, Finds Study

Par : msmash
27 mars 2024 à 14:40
Two nights of broken sleep are enough to make people feel years older, according to researchers, who said consistent, restful slumber was a key factor in helping to stave off feeling one's true age. From a report: Psychologists in Sweden found that, on average, volunteers felt more than four years older when they were restricted to only four hours of sleep for two consecutive nights, with some claiming the sleepiness made them feel decades older. The opposite was seen when people were allowed to stay in bed for nine hours, though the effect was more modest, with participants in the study claiming to feel on average three months younger than their real age after ample rest. "Sleep has a major impact on how old you feel and it's not only your long-term sleep patterns," said Dr Leonie Balter, a psychoneuroimmunologist at the Karolinska Institute in Stockholm and first author on the study. "Even when you only sleep less for two nights that has a real impact on how you feel." Beyond simply feeling more decrepit, the perception of being many years older may affect people's health, Balter said, by encouraging unhealthy eating, reducing physical exercise, and making people less willing to socialise and engage in new experiences.

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Pregnancy May Increase Biological Age 2 Years - But Some End Up 'Younger'

Par : EditorDavid
23 mars 2024 à 16:34
Slashdot reader sciencehabit shared this report from Science magazine: Nurturing a growing fetus requires a series of profound physical, hormonal, and chemical changes that may rewire every major organ in the body and can cause serious health complications such as hypertension and preeclampsia. But does being pregnant actually take years off your life...? Today in Cell Metabolism, scientists report that the stress of pregnancy can cause a person's biological age to increase by up to 2 years — a trend that may reverse itself in the months that follow. In some cases, the authors write, those who breastfeed their children after giving birth may end up biologically "younger" than during early pregnancy. The finding represents yet another piece of "compelling" evidence that events during and after pregnancy can have far-reaching health consequences, says Elizabeth Bertone-Johnson, an epidemiologist at the University of Massachusetts Amherst who wasn't involved in the new study... The discovery that biological aging isn't necessarily a linear process "came as a real surprise," says Kieran O'Donnell, a perinatal researcher at the Yale School of Medicine... But blood samples from 68 participants, collected 3 months after giving birth, revealed a dramatic about-face. Although being pregnant had initially aged their cells between 1 and 2 years, says O'Donnell, their biological age now appeared to be 3 to 8 years younger than it had been during early pregnancy — with different epigenetic clocks algorithms providing slightly bigger or smaller estimates.

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First Human Transplant of a Genetically Modified Pig Kidney Performed

Par : msmash
21 mars 2024 à 15:22
For the first time, surgeons have transplanted a kidney from a genetically modified pig into a living person, doctors in Boston said Thursday. From a report: Richard Slayman, 62, of Weymouth, Mass., who is suffering from end-stage kidney disease, received the organ Saturday in a four-hour procedure, Massachusetts General Hospital announced. He is recovering well and is expected to be discharged soon, the hospital said. "I saw it not only as a way to help me, but a way to provide hope for the thousands of people who need a transplant to survive," Slayman said in a statement released by the hospital. The procedure is the latest development in a fast-moving race to create genetically modified pigs to provide kidneys, livers, hearts and other organs to help alleviate the shortage of organs for people who need transplants. "Our hope is that this transplant approach will offer a lifeline to millions of patients worldwide who are suffering from kidney failure," said Dr. Tatsuo Kawai, the hospital's director for clinical transplant tolerance, in the hospital statement. Several biotech companies are racing to develop a supply of cloned pigs whose DNA has been genetically modified so they won't be rejected by the human body, spread pig viruses to people or cause other complications. NPR recently got exclusive access to a research farm breeding these animals for a company in this competition, Revivicor Inc. of Blacksburg, Va. The kidney transplanted in Boston came from a pig created by eGenesis of Cambridge, Mass. The eGenesis pigs are bred with 69 genetic modifications to prepare organs for human transplantation. The changes protect against a virus known to infect pigs as well as delete pig genes and add human genes to make the organs compatible with people.

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Superconductor Scientist Engaged in Research Misconduct, Probe Finds

Par : msmash
21 mars 2024 à 14:45
A physicist who shot to fame with claims of the discovery of a room-temperature superconductor engaged in research misconduct, a committee tapped to examine his work has concluded after a monthslong investigation. From a report: Ranga Dias, a physicist at the University of Rochester in New York, has had at least four papers he co-wrote, including three involving superconductivity, retracted in the past 18 months by the journals that published them. A committee of outside experts tapped by the university "identified data-reliability concerns in those papers," a Rochester spokesperson told The Wall Street Journal. "The committee concluded, in accordance with university policy and federal regulations, that Dias engaged in research misconduct," the spokesperson said in an emailed statement. The work in the papers was funded by the National Science Foundation, the Energy Department, and the Gordon and Betty Moore Foundation, a private organization that funds scientific research. The Moore foundation discontinued its grant late last year, the organization said. Of the $1.6 million award, about $285,000 was spent. The university refunded the rest. The investigation follows three preliminary reviews by the university of one of the studies, published in Nature in 2020 and retracted in 2022 after criticism from other scientists. Those inquiries didn't find enough evidence to prompt a full investigation. Complaints sent to the university in spring 2023 about additional studies prompted a more thorough review. That investigation was completed by March this year, resulting in the misconduct finding. The journal Nature reported earlier this month that this investigation was complete.

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3D Images of Over 13,000 Museum Specimens Now Free To Everyone

Par : BeauHD
12 mars 2024 à 07:00
The openVertebrate (oVert) project is now complete, offering free online access to incredibly detailed 3D images of over 13,000 vertebrates. New Atlas reports: More than a research project, oVert was a collaboration between like-minded specialists across 25 institutions whose sole objective was to add value to museum collections by making them more widely available. Importantly, these images provide an insight that would only otherwise be obtained by destructive dissection and tissue sampling. Over the course of six years, project members took CT scans of more than half the classes, or genera, of all amphibians, reptiles, fishes, birds, and mammals, rendering models that provide an intimate look at the creatures, inside and out. [...] For a working example of the incredible detail and information contained in oVert's images, head to Sketchfab to view a sample of interactive 3D models like the olive sea snake. Or go to MorphoSource to access the full oVert repository. [...] If you have 30 minutes to spare, check out the full video produced by the Florida Museum, which showcases a collection of diverse oVert specimens. A study presenting a summary of the oVert project was published in the journal BioScience.

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Are We in the 'Anthropocene,' the Human Age? Scientists Say: Nope

Par : EditorDavid
10 mars 2024 à 19:34
Science magazine "has confirmed that a panel of two dozen geologists has voted down a proposal to end the Holocene — our current span of geologic time, which began 11,700 years ago at the end of the last ice age — and inaugurate a new epoch, the Anthropocene. "Starting in the 1950s, it would have marked a time when humanity's influence on the planet became overwhelming." The vote, first reported by The New York Times, is a stunning — though not unexpected — rebuke for the proposal, which has been working its way through a formal approval process for more than a decade... [S]ome felt the proposed marker of the epoch — some 10 centimeters of mud from Canada's Crawford Lake that captures the global surge in fossil fuel burning, fertilizer use, and atomic bomb fallout that began in the 1950s — isn't definitive enough. Others questioned whether it's even possible to affix one date to the start of humanity's broad planetary influence: Why not the rise of agriculture? Why not the vast changes that followed European encroachment on the New World? Stanley Finney, a stratigrapher at California State University Long Beach and head of the International Union of Geological Sciences, said "It would have been rejected 10 years earlier if they had not avoided presenting it to the stratigraphic community for careful consideration." Finney also complains that from the start, AWG was determined to secure an "epoch" categorization, and ignored or countered proposals for a less formal Anthropocene designation.... The Anthropocene backers will now have to wait for a decade before their proposal can be considered again... Even if it is not formally recognized by geologists, the Anthropocene is here to stay. It is used in art exhibits, journal titles, and endless books... And others have advanced the view that it can remain an informal geologic term, calling it the "Anthropocene event...." From the New York Times: Geoscientists don't deny our era stands out within that long history. Radionuclides from nuclear tests. Plastics and industrial ash. Concrete and metal pollutants. Rapid greenhouse warming. Sharply increased species extinctions. These and other products of modern civilization are leaving unmistakable remnants in the mineral record, particularly since the mid-20th century. Still, to qualify for its own entry on the geologic time scale, the Anthropocene would have to be defined in a very particular way, one that would meet the needs of geologists and not necessarily those of the anthropologists, artists and others who are already using the term. That's why several experts who have voiced skepticism about enshrining the Anthropocene emphasized that the vote against it shouldn't be read as a referendum among scientists on the broad state of the Earth. "This was a narrow, technical matter for geologists, for the most part," said one of those skeptics, Erle C. Ellis, an environmental scientist at the University of Maryland, Baltimore County. "This has nothing to do with the evidence that people are changing the planet," Dr. Ellis said. "The evidence just keeps growing." Francine M.G. McCarthy, a micropaleontologist at Brock University in St. Catharines, Ontario, is the opposite of a skeptic: She helped lead some of the research to support ratifying the new epoch. "We are in the Anthropocene, irrespective of a line on the time scale," Dr. McCarthy said. "And behaving accordingly is our only path forward." Thanks to Slashdot reader sciencehabit for sharing the news.

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Company That Plans To Bring Back the Mammoth Takes a Key Step

Par : BeauHD
8 mars 2024 à 02:10
John Timmer reports via Ars Technica: A company called Colossal plans to pioneer the de-extinction business, taking species that have died within the past few thousand years and restoring them through the use of DNA editing and stem cells. It's grabbed headlines recently by announcing some compelling targets: the thylacine, an extinct marsupial predator, and an icon of human carelessness, the dodo. But the company was formed to tackle an even more audacious target: the mammoth, which hasn't roamed the Northern Hemisphere for thousands of years. Obviously, there are a host of ethical and conservation issues that would need to be worked out before Colossal's plans go forward. But there are some major practical hurdles as well, most of them the product of the distinct and extremely slow reproductive biology of the mammoth's closest living relatives, the elephants. At least one of those has now been cleared, as the company is announcing the production of the first elephant stem cells. The process turned out to be extremely difficult, suggesting that the company still has a long road ahead of it. [...] Overall, it's a project that has a high probability of failure and may ultimately require generations of scientists. If we do successfully de-extinct a species, the first example will probably be a different species, even though the projects launched later. But Colossal is forging ahead and cleared one of the many hurdles it faces: It created the first induced stem cells from elephants and will be placing a draft manuscript describing the process on a public repository on Wednesday. (Colossal provided Ars with an advanced version of the draft that, outside of a few editing errors, appears largely complete.) Beyond providing the technical details of how the process works, the manuscript describes a long, failure-ridden route to eventual success. Several methods have been developed to allow us to induce stem cells from the cells of an adult organism. The original Nobel-winning process developed by Shinya Yamanaka involved inserting the genes that encode four key embryonic regulatory genes into adult cells and allowing them to reprogram the adult cell into an embryonic state. That has proven effective in a variety of species but has a couple of drawbacks due to the fact that the four genes can potentially stick around, interfering with later development steps. Although there are ways around that, others have developed a cocktail of chemicals that perform a similar function by activating signaling pathways that, collectively, can also reprogram adult cells. When it works, this simplifies matters, as you only have to remove the chemicals to allow the stem cells to adopt other fates. Colossal tried both of these. Neither worked with elephant cells: "Multiple attempts with current standard reprogramming methods were tried, and failed, and resulted in no, or incomplete, reprogramming." Apparently, lots of additional trial and error ensued. The eventual solution ended up being based in part on combining the two primary options: Cells were first exposed to a chemical reprogramming cocktail and then given the four genes used in the alternative reprogramming method. On its own, however, that wasn't enough. The researchers also had to address a quirk of elephant biology. Obviously, for Colossal, this is a means to an end: the mammoth. But that's remarkably underplayed in the manuscript. Instead, its emphasis is on the technology's use in the conservation of existing species. [T]he researchers note that studying things like elephant development and metabolism in actual elephants is not especially realistic. But we can potentially induce the stem cells developed here into any cell we'd want to study -- nerve, liver, heart, and so on. So, the stem cells described here could be a useful tool for research. So, these cells are being presented as a valuable tool for the research community. Still, you can expect the people behind the de-extinction project to be getting to work on some of the easier things: showing that the genome in the cells can be edited and that they can be induced to start the process of embryogenesis. Separately, some unfortunate individuals will need to be working on the hard problems we mentioned earlier.

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Millions of Research Papers at Risk of Disappearing From the Internet

Par : msmash
7 mars 2024 à 14:01
More than one-quarter of scholarly articles are not being properly archived and preserved, a study of more than seven million digital publications suggests. From a report: The findings, published in the Journal of Librarianship and Scholarly Communication on 24 January, indicate that systems to preserve papers online have failed to keep pace with the growth of research output. "Our entire epistemology of science and research relies on the chain of footnotes," explains author Martin Eve, a researcher in literature, technology and publishing at Birkbeck, University of London. "If you can't verify what someone else has said at some other point, you're just trusting to blind faith for artefacts that you can no longer read yourself." Eve, who is also involved in research and development at digital-infrastructure organization Crossref, checked whether 7,438,037 works labelled with digital object identifiers (DOIs) are held in archives. DOIs -- which consist of a string of numbers, letters and symbols -- are unique fingerprints used to identify and link to specific publications, such as scholarly articles and official reports. Crossref is the largest DOI registration agency, allocating the identifiers to about 20,000 members, including publishers, museums and other institutions. The sample of DOIs included in the study was made up of a random selection of up to 1,000 registered to each member organization. Twenty-eight percent of these works -- more than two million articles -- did not appear in a major digital archive, despite having an active DOI. Only 58% of the DOIs referenced works that had been stored in at least one archive. The other 14% were excluded from the study because they were published too recently, were not journal articles or did not have an identifiable source.

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Ask Slashdot: Can You Picture Things in Your Mind?

Par : EditorDavid
4 mars 2024 à 12:34
"It never occurred to me that having no visual imagery was unusual..." writes a science journalist at the Guardian. "It's not that I forget what I look like, but I am sometimes a little surprised, and don't feel connected to my outward appearance as a matter of identity." There's been a surge of research on how aphantasia affects our lives... [F]or some it affects images alone; some can't imagine other sensory information, like sounds. Some people with aphantasia have visualizations when they dream (I do), and others don't. There's evidence that it can make it harder for people to recall visual details, though other studies show that aphants perform better on some memory tests unrelated to imagery... But overall, people with aphantasia don't seem to have serious problems navigating their day-to-day lives, unlike those with more severe memory conditions like episodic amnesia... Some people consider aphantasia to be a deficit and wish they could reverse it. People have claimed they can train their way out of aphantasia, or use psychedelics to regain some sense of mental imagery (the jury is out on whether that works). I have no desire for this — my mind is plenty busy without a stream of imagery. If I was born with imagery, it would be commonplace for me, and I'm sure I'd enjoy it. But I already can find myself overwhelmed with thoughts and feelings that have no visual aspects to them. Long-time Slashdot reader whoever57 writes that "Personally, I never realized before reading this article that people could create mental images." (And they also wonder if people with the condition tend to go into STEM fields.) There's what's known as the "red apple test," where you rate your own ability to visualize an apple on a scale of 1 to 5. Any Slashdot readers want to share their own experiences in the comments?

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La comète du diable doit son surnom à d’imprévisibles explosions

Par : Nelly Lesage
4 mars 2024 à 10:37

La comète 12P/Pons-Brooks est surveillée attentivement, car elle pourrait devenir visible à l'œil nu en mars ou avril 2024. D'où vient son intrigant surnom de « comète du diable » ?

New Study Shows Like-Charged Particles Attract or Repel in Solution

Par : EditorDavid
2 mars 2024 à 19:34
You know how like-charged objects repel — and do so regardless of the sign of their electrical charge? Maybe not always, according to new research published in Nature. "We demonstrate experimentally that the solvent plays a hitherto unforeseen but crucial role in interparticle interactions," they write. But more importantly, "interactions in the fluid phase can break charge-reversal symmetry. We show that in aqueous solution, negatively charged particles can attract at long range while positively charged particles repel. [In solvents like alcohols "that exhibit an inversion of the net molecular dipole at an interface"], positively charged particles may attract whereas negatives repel. The observations hold across a wide variety of surface chemistries: from inorganic silica and polymeric particles to polyelectrolyte- and polypeptide-coated surfaces in aqueous solution. A theory of interparticle interactions that invokes solvent structuring at an interface captures the observations. Our study establishes a nanoscopic interfacial mechanism by which solvent molecules may give rise to a strong and long-ranged force in solution, with immediate ramifications for a range of particulate and molecular processes across length scales such as self-assembly, gelation and crystallization, biomolecular condensation, coacervation, and phase segregation. The delicate interplay of interactions between objects in the fluid phase influences the behaviour, organization and properties of systems from nanometric to more macroscopic size and length scales and thus underpins a wealth of natural phenomena... Thanks to long-time Slashdot reader Greymane for sharing the article.

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Ultraprocessed Foods Linked To Heart Disease, Diabetes, Mental Disorders and Early Death, Study Finds

Par : msmash
29 février 2024 à 18:01
Eating ultraprocessed foods raises the risk of developing or dying from dozens of adverse health conditions, according to a new review of 45 meta-analyses on almost 10 million people. From a report: "We found consistent evidence linking higher intakes of ultra-processed foods with over 70% of the 45 different health outcomes we assessed," said senior author Wolfgang Marx, a senior research fellow at the Food & Mood Centre at Deakin University in Geelong, Australia, in an email. A higher intake was considered about one serving or about 10% more ultraprocessed foods per day, said Heinz Freisling, a scientist in the nutrition and metabolism branch of the World Health Organization's International Agency for Research on Cancer, in an email. "This proportion can be regarded as 'baseline' and for people consuming more than this baseline, the risk might increase," said Freisling, who was not involved in the study. Researchers graded each study as having credible or strong, highly suggestive, suggestive, weak or no evidence. All the studies in the review were published in the past three years, and none was funded by companies involved in the production of ultraprocessed foods, the authors said. "Strong evidence shows that a higher intake of ultra-processed foods was associated with approximately 50% higher risk of cardiovascular disease-related death and common mental disorders," said lead author Dr. Melissa Lane, a postdoctoral research fellow at Deakin, in an email. Cardiovascular disease encompasses heart attacks, stroke, clogged arteries and peripheral artery disease. The study: Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses (BMJ)

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The Strange and Turbulent Global World of Ant Geopolitics

Par : msmash
28 février 2024 à 16:40
Over the past four centuries quadrillions of ants have created a strange and turbulent global society that shadows our own. An excerpt from an Aeon article: In their native ranges, these multi-nest colonies can grow to a few hundred metres across, limited by physical barriers or other ant colonies. This turns the landscape to a patchwork of separate groups, with each chemically distinct society fighting or avoiding others at their borders. Species and colonies coexist, without any prevailing over the others. However, for the 'anonymous societies' of unicolonial ants, as they're known, transporting a small number of queens and workers to a new place can cause the relatively stable arrangement of groups to break down. As new nests are created, colonies bud and spread without ever drawing boundaries because workers treat all others of their own kind as allies. What was once a patchwork of complex relationships becomes a simplified, and unified, social system. The relative genetic homogeneity of the small founder population, replicated across a growing network of nests, ensures that members of unicolonial species tolerate each other. Spared the cost of fighting one another, these ants can live in denser populations, spreading across the land as a plant might, and turning their energies to capturing food and competing with other species. Chemical badges keep unicolonial ant societies together, but also allow those societies to rapidly expand.

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[2401.11817] Hallucination is Inevitable: An Innate Limitation of Large Language Models

27 février 2024 à 09:46
Jusqu'à présent les travaux pour limiter le baratinage des IA avaient toujours été empiriques (et souvent réalisés à coup de populations pauvres payées 2$ de l'heure : https://sebsauvage.net/links/?eaX_tQ, https://sebsauvage.net/links/?RZ7ziw), mais cette publication scientifique démontre que les "hallucinations" (aka le baratinage) des LLM n'est pas possible à éliminer.

EDIT: Article en français : https://intelligence-artificielle.developpez.com/actu/354600/L-hallucination-est-inevitable-et-serait-une-limitation-innee-des-grands-modeles-de-langage-en-intelligence-artificielle-selon-une-etude-sur-la-possibilite-d-eliminer-les-hallucinations-des-LLM/
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Varda Space, Rocket Lab Nail First-of-Its-Kind Spacecraft Landing in Utah

Par : msmash
22 février 2024 à 16:00
A spacecraft containing pharmaceutical drugs that were grown on orbit has finally returned to Earth today after more than eight months in space. From a report: Varda Space Industries' in-space manufacturing capsule, called Winnebago-1, landed in the Utah desert at around 4:40 p.m. EST. Inside the capsule are crystals of the drug ritonavir, which is used to treat HIV/AIDS. It marks a successful conclusion of Varda's first experimental mission to grow pharmaceuticals on orbit, as well as the first time a commercial company has landed a spacecraft on U.S. soil, ever. The capsule will now be sent back to Varda's facilities in Los Angeles for analysis, and the vials of ritonavir will be shipped to a research company called Improved Pharma for post-flight characterization, Varda said in a statement. The company will also be sharing all the data collected through the mission with the Air Force and NASA, per existing agreements with those agencies. The first-of-its-kind reentry and landing is also a major win for Rocket Lab, which partnered with Varda on the mission. Rocket Lab hosted Varda's manufacturing capsule inside its Photon satellite bus; through the course of the mission, Photon provided power, communications, attitude control and other essential operations. At the mission's conclusion, the bus executed a series of maneuvers and de-orbit burns that put the miniature drug lab on the proper reentry trajectory. The final engine burn was executed shortly after 4 p.m. EST. Photon burned up in the atmosphere as planned while the capsule, protected by a heat shield and with the aid of a parachute, continued to land.

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LENIA : Une nouvelle forme de vie mathématique ! - YouTube

21 février 2024 à 14:32
Un système de vie artificielle qui a l'air assez évolué et permet d'avoir plein de comportements intéressants. C'est un peu comme le jeu de la vie de Conway, mais avec un système non discret.

EDIT: Autre vidéo sur la vie artificielle : https://www.youtube.com/watch?v=Jdaz5e_a5xk
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Making Alarms More Musical Can Save Lives

Par : msmash
20 février 2024 à 20:40
Medical alarms don't have to be louder to be more effective. Scientific American: Beeping alarms in hospitals are a life-or-death matter -- but with so many going off all the time, medical professionals may experience alarm fatigue that impairs care. Researchers now report that changing an alarm's sound to incorporate properties of musical instruments can make it more helpful amid the din. Auditory alarms can sound up to 300 times a day per patient in U.S. hospitals, but only a small fraction require immediate action. Data from the U.S. Food and Drug Administration suggest that alarm fatigue (including when clinicians turned off or forgot to restart alarms) and other alarm-related issues were linked to 566 deaths over five and a half years. After a typical day at the hospital, "I'd leave with beeping in my ears," says Vanderbilt University Medical Center anesthesiologist Joseph Schlesinger. He collaborated with Michael Schutz, a music cognition researcher at McMaster University in Ontario, to analyze how musical sounds could improve hospital alarms. In 2015 Schutz and Schlesinger began examining musical qualities called timbres that might let softer sounds command attention from busy clinicians. They found that sounds with a "percussive" timbre, many of which contain short bursts of high-frequency energy -- such as wineglasses clinking -- stand out even at low volume. In contrast, loud, "flat" tones that lack high-frequency components, like a reversing truck's beep, get lost. The researchers have since conducted experiments in which participants evaluate different sounds and melodies for annoyance, detectability and recognizability. For a recent study detailed in Perioperative Care and Operating Room Management, the researchers played participants the same sequences of notes with varying timbres. They found the sounds that made these sequences least annoying, with no decrease in recall, were percussive and had complex, time-varied harmonic overtones (the many components within a single sound) like a xylophone's ping, rather than a few homogeneous ones like monotonous mechanical beeps.

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Neuralink's First Human Patient Able To Control Mouse Through Thinking, Musk Says

Par : msmash
20 février 2024 à 16:42
The first human patient implanted with a brain-chip from Neuralink appears to have fully recovered and is able to control a computer mouse using their thoughts, the startup's founder Elon Musk said late on Monday. From a report: "Progress is good, and the patient seems to have made a full recovery, with no ill effects that we are aware of. Patient is able to move a mouse around the screen by just thinking," Musk said in a Spaces event on social media platform X. Musk said Neuralink was now trying to get as many mouse button clicks as possible from the patient. The firm successfully implanted a chip on its first human patient last month, after receiving approval for human trial recruitment in September.

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