Longtime Slashdot reader backslashdot writes: Commentary, video, and a publication in this week's Nature Neuroscience herald a significant advance in brain-computer interface (BCI) technology, enabling speech by decoding electrical activity in the brain's sensorimotor cortex in real-time. Researchers from UC Berkeley and UCSF employed deep learning recurrent neural network transducer models to decode neural signals in 80-millisecond intervals, generating fluent, intelligible speech tailored to each participant's pre-injury voice. Unlike earlier methods that synthesized speech only after a full sentence was completed, this system can detect and vocalize words within just three seconds. It is accomplished via a 253-electrode array chip implant on the brain. Code and the dataset to replicate the main findings of this study are available in the Chang Lab's public GitHub repository.

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Scientists in China successfully transplanted a genetically modified pig liver into a brain-dead patient, where it functioned for 10 days. The liver, modified to reduce immune rejection, produced key proteins and bile, showing compatibility and offering hope for future short-term xenotransplants. The Guardian reports: The surgery, at a Chinese hospital last year, is thought to mark the first time a pig liver has been transplanted into a human. It raises the prospect of pig livers serving as a "bridging organ" for patients on the waiting list for a transplant or to support liver function while their own organ regenerates. [...] The latest procedure was carried out in a 50-year-old man diagnosed with brain death after a severe head injury. The patient's own liver was intact and, in a surgery that took more than 10 hours, the organ taken from a genetically modified Bama miniature pig was plumbed into his blood supply as an additional liver. The pig had six genetic modifications aimed at preventing immune rejection. These included deactivating genes that contribute to the production of sugars on the surface of pig cells, which the human immune system attacks, and introducing genes that express human proteins to "humanize" the liver. After the transplant, the pig liver showed signs of functioning, including producing bile, which helps break down fats in the digestive system, and porcine albumin, a blood protein. The team behind the advance, described in the journal Nature, said it was not clear whether the liver would have been able to fully support the patient, given that he had an existing liver and because the liver was removed after 10 days at the request of his family.

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NPR reports on research "into whether our defenses built up from past flu seasons can offer any protection against H5N1 bird flu." So far, the findings offer some reassurance. Antibodies and other players in the immune system may buffer the worst consequences of bird flu, at least to some degree. "There's certainly preexisting immunity," says Florian Krammer, a virologist at Mount Sinai's Icahn School of Medicine who is involved in some of the new studies. "That's very likely not going to protect us as a population from a new pandemic, but it might give us some protection against severe disease." This protection is based on shared traits between bird flu and types of seasonal flu that have circulated among us. Certain segments of the population, namely older people, may be particularly well-primed because of flu infections during early childhood. Of course, there are caveats. "While this is a bit of a silver lining, it doesn't mean we should all feel safe," says Seema Lakdawala, a virologist at Emory University's School of Medicine whose lab is probing this question. For one thing, the studies can't be done on people. The conclusions are based on animal models and blood tests that measure the immune response. And how this holds up for an individual is expected to vary considerably, depending on their own immune history, underlying health conditions and other factors. But for now, influenza researchers speculate this may be one reason most people who've caught bird flu over the past year have not fallen severely ill.... Research published this month is encouraging. By analyzing blood samples from close to 160 people, a team at the University of Pennsylvania and the University of Chicago were able to show that people born roughly before 1965 had higher levels of antibodies — proteins that bind to parts of the virus — which cross-react to the current strain of bird flu. This week U.S. federal officials also "announced funding for avian influenza research projects, including money for new vaccine projects and potential treatments," the Guardian report. The head of America's agriculture department said it would invest $100 million, as part of a larger $1 billion initiative to fight bird flu and stop rising egg prices, according to the nonprofit news site Iowa Capital Dispatch.

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A newly FDA-approved form of adaptive deep-brain stimulation (DBS) for Parkinson's disease adjusts electrical stimulation in real time based on an individual's brain signals, improving symptom control and reducing medication dependence. Scientific American: For decades, Keith Krehbiel took high doses of medications with a debilitating side effect -- severe nausea -- following his diagnosis with early-onset Parkinson's disease at age 42 in 1997. When each dose wore off, he experienced dyskinesia -- involuntary, repetitive muscle movements. In his case, this consisted of head bobbing and weaving. Krehbiel is among one million Americans who live with this progressive neurological disorder, which causes slowed movements, tremors and balance problems. But soon after surgery to implant electrodes into specific areas of his brain in 2020, his life dramatically improved. "My tremor went away almost entirely," says Krehbiel, now age 70 and a professor emeritus of political science at the Stanford Graduate School of Business, whose Parkinson's symptoms began at age 40 and were initially misdiagnosed as repetitive stress injury from computer use. "I reduced my Parkinson's meds by more than two thirds," he adds. "And I no longer have a sensation of a foggy brain, nor nausea or dyskinesia." Krehbiel was the first participant to enroll in a clinical trial testing a new form of deep-brain stimulation (DBS), a technology that gained approval from the U.S. Food and Drug Administration for Parkinson's tremor and essential tremor in 1997 (it was later approved for other symptoms and conditions). The new adaptive system adjusts stimulation levels automatically based on the person's individual brain signals. In late February it received FDA approval for Parkinson's disease "based on results of the international multicenter trial, which involved participants at 10 sites across a total of four countries -- the U.S., the Netherlands, Canada and France. This technology is suitable for anyone with Parkinson's, not just individuals in clinical trials, says Helen Bronte-Stewart, the recent trial's global lead investigator and a neurologist specializing in movement disorders at Stanford Medicine. "Like a cardiac pacemaker that responds to the rhythms of the heart, adaptive deep-brain stimulation uses a person's individual brain signals to control the electric pulses it delivers," Bronte-Stewart says. "This makes it more personalized, precise and efficient than older DBS methods." "Traditional DBS delivers constant stimulation, which doesn't always match the fluctuating symptoms of Parkinson's disease," adds neurologist Todd Herrington, another of the trial's investigators and director of the deep-brain stimulation program at Massachusetts General Hospital. With adaptive DBS, "the goal is to adjust stimulation in real time to provide more effective symptom control, fewer side effects and improved patient quality of life." Current FDA approval of this adaptive system is for the treatment of Parkinson's only, not essential tremor, dystonia (a neurological disorder that causes excessive, repetitive and involuntary muscle contractions) or epilepsy, which still rely on traditional, continuous DBS, Herrington says.

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A blog post from the Stanford University School of Medicine attempts to answer the question: What's the deal with the gut-brain connection? It affects your mood, your sleep, even your motivation to exercise. There's convincing evidence that it's the starting point for Parkinson's disease and could be responsible for long COVID's cognitive effects. And it sits about 2 feet below your brain. The gut plays an obvious role in our health by digesting what we eat and extracting nutrients. But there's a growing appreciation among scientists that our digestive systems affect our general well-being in a much broader fashion. One fascinating aspect of the gut's widespread impact on health is its direct influence on and communication with the brain, a conduit known as the gut-brain axis. Through direct signals from the vagus nerve, [which] connects the brain and the gut, as well as through molecules secreted into the bloodstream from our gut microbes and immune cells that traffic from the gut to the rest of the body, our brains and our digestive tracts are in constant communication. And when that communication goes off the rails, diseases and disorders can result. The gut-brain connection is a key part of how the brain forms a picture of the rest of the body, a phenomenon known as interoception, explained Christoph Thaiss, PhD, an assistant professor of pathology at Stanford Medicine... The gut also contains the largest number of neurons outside the brain of any structure in the body — more than 100 million neurons line the human digestive tract, from the esophagus to the anus. These cells make up what is known as the enteric nervous system, which some scientists refer to as a "second brain." The enteric nervous system is more brain-like than other peripheral nerves because it consists of lots of different types of neurons that communicate with each other, while other peripheral nerves primarily serve to communicate between the brain and the body, said Julia Kaltschmidt, PhD, the Firmenich Next Generation Faculty Scholar and an associate professor of neurosurgery. In fact, the gut's nervous system can act alone. Scientists have found that if they remove an animal's gut and bathe it in a special fluid designed to keep neurons alive, the gut continues to contract, pushing its contents from top to bottom.

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Australian company Cortical Labs has launched the CL1, the world's first commercial "biological computer" that merges human brain cells with silicon hardware to form adaptable, energy-efficient neural networks. New Atlas reports: Known as a Synthetic Biological Intelligence (SBI), Cortical's CL1 system was officially launched in Barcelona on March 2, 2025, and is expected to be a game-changer for science and medical research. The human-cell neural networks that form on the silicon "chip" are essentially an ever-evolving organic computer, and the engineers behind it say it learns so quickly and flexibly that it completely outpaces the silicon-based AI chips used to train existing large language models (LLMs) like ChatGPT. "Today is the culmination of a vision that has powered Cortical Labs for almost six years," said Cortical founder and CEO Dr Hon Weng Chong. "We've enjoyed a series of critical breakthroughs in recent years, most notably our research in the journal Neuron, through which cultures were embedded in a simulated game-world, and were provided with electrophysiological stimulation and recording to mimic the arcade game Pong. However, our long-term mission has been to democratize this technology, making it accessible to researchers without specialized hardware and software. The CL1 is the realization of that mission." He added that while this is a groundbreaking step forward, the full extent of the SBI system won't be seen until it's in users' hands. "We're offering 'Wetware-as-a-Service' (WaaS)," he added -- customers will be able to buy the CL-1 biocomputer outright, or simply buy time on the chips, accessing them remotely to work with the cultured cell technology via the cloud. "This platform will enable the millions of researchers, innovators and big-thinkers around the world to turn the CL1's potential into tangible, real-word impact. We'll provide the platform and support for them to invest in R&D and drive new breakthroughs and research." These remarkable brain-cell biocomputers could revolutionize everything from drug discovery and clinical testing to how robotic "intelligence" is built, allowing unlimited personalization depending on need. The CL1, which will be widely available in the second half of 2025, is an enormous achievement for Cortical -- and as New Atlas saw recently with a visit to the company's Melbourne headquarters -- the potential here is much more far-reaching than Pong. [...]

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San Francisco-based biotech startup Loyal says a drug it developed to increase dogs' lifespan "has passed a significant milestone on the way to regulatory approval," reports the Washington Post: The Food and Drug Administration certified the daily pill as having a "reasonable expectation of effectiveness" at extending senior dogs' lifespans. The regulator's Center for Veterinary Medicine still has to certify that the drug is safe and that Loyal can manufacture it at scale before vets can prescribe the pill to dogs 10 years or older that weigh 14 pounds or more. Loyal's CEO, Celine Halioua, estimates that the process should be complete by the end of 2025 and called the FDA's initial recognition "a key step" to extending dogs' lives... In the past decade, a subculture of tech entrepreneurship has focused on helping people stave off death, hawking custom-made dietary supplements and $2,500 full-body MRIs and investing in the development of antiaging drugs, among many other efforts. According to data firm Pitchbook, about $900 million in venture capital has been poured into antiaging and longevity start-ups in the past 12 months. Loyal has raised more than $150 million in venture funding since its 2019 founding to develop lifespan-extending drugs initially focused on canines. Launching veterinary drugs is in some ways easier than winning approval for human treatments. Because dogs and humans have evolved alongside one another, Halioua hopes to eventually apply her findings about pets to help prolong their owners' lives. "If we can successfully delay the onset and severity of age-related diseases in dogs, it's extremely compelling evidence that it will also do that in humans," Halioua said. The biological processes of aging unfold faster in dogs because they live such short lives, she said, helping researchers and entrepreneurs probe how they work. "Loyal's pill is a result of research into how to mimic the life-extending benefit of caloric restriction without the appetite suppression," according to the article, "and without the need for an owner to restrict their dog's food. "The drug aims to improve a dog's metabolic fitness, or the body's ability to convert nutrients into energy and regulate hormones, which declines in humans and canines with age..."

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Google has received FDA clearance for the Pixel Watch 3's Loss of Pulse Detection feature, which will start rolling out to U.S. devices around the end of March. The Verge reports: The Loss of Pulse Detection feature is exactly what it sounds like: if the Pixel Watch 3 senses that you've lost your pulse through an event like a heart attack or an overdose, it'll send you a prompt. If you don't respond, it'll automatically call emergency services on your behalf. Back in August, Sandeep Waraich, Google's senior director of product manager for Pixel wearables, told The Verge that the Pixel Watch 3 is capable of differentiating between a genuine loss-of-pulse event and a person simply taking the watch off.

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New research suggests that anthocyanins, the antioxidants responsible for the vibrant colors of fruits and flowers, may help counteract reproductive harm caused by microplastics. The Guardian reports: The new review of scientific literature on anthocyanins found that the compounds are probably protective against a range of plastic-induced impacts on hormones, reductions in testosterone and estrogen, decreased sperm counts, lower sperm quality, erectile dysfunction and ovarian damage. [...] Researchers said that mice exposed to microplastics, then treated with anthocyanins, showed increased sperm quality, including increased sperm count and motility, and the antioxidants overall reduced testicular damage. The new paper also pointed to research that found some microplastics reduce testosterone levels because they harm Leydig cells, which are responsible for the hormone's production. Anthocyanins seem to helped restore testosterone production and protect Leydig cells. In women, impacts on fertility and sexual development could be mitigated by anthocyanins that seem to protect hormone receptors from plastic chemicals such as bisphenol, phthalates and cadmium. The chemicals can mimic hormones, or cause hormonal responses. Microplastics in ovarian tissue cause inflammation that seems to lower levels of estrogen and other hormones. Research found that treating rats exposed to microplastics protected the ovarian tissue and normalized levels of estrogen and other hormones. "Its antioxidant properties help preserve ovarian function and potentially maintain fertility, highlighting its therapeutic potential in managing ovarian damage," the authors wrote.

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An anonymous reader quotes a report from New Atlas: New research by Purdue University, the latest in a series of Purdue-led studies, examined how scented products -- in this case, flame-free candles -- are a significant source of nanosized particles small enough to get deep into your lungs, posing a potential risk to respiratory health [...] Scented wax melts are marketed as a flameless, smoke-free, non-toxic alternative to traditional candles, a safer way of making your home or office smell nice. To assess the truth of these claims, the researchers comprehensively measured the nanoparticles formed when they warmed wax melts in their mechanically ventilated test house. The tiny house is actually an architectural engineering laboratory called the Purdue Zero Energy Design Guidance for Engineers (zEDGE) lab. Designed and engineered to test the energy efficiency of a larger building, it's full of sensors that monitor the impact of everyday activities on indoor air quality. The researchers knew from their previous research that new nanoparticle formation was initiated by terpenes -- aromatic compounds that determine the smell of things like plants and herbs -- released from the melts and reacting with indoor atmospheric ozone (O3). They'd found that activities such as mopping the floor with a terpene-rich cleaning agent, using a citrus-scented air freshener, or applying scented personal care products like deodorant inside the zEDGE house resulted in pulsed terpene emissions to the indoor air within five minutes. Conversely, using essential oil diffusers or peeling citrus fruits caused a more gradual increase in terpenes. In the present study, heating the scented wax contributed significantly to the number of new particles formed in the indoor air, particularly those smaller than 100 nanometers (nm). The resulting atmospheric concentrations were over one million nanoparticles per cubic centimeter (106 cm-3), which is comparable to concentrations emitted by traditional lighted candles (106 cm-3), gas stoves (105 - 107 cm-3), diesel engines (103 - 106 cm-3), and natural gas engines (106 - 107 cm-3). By comparison, there were no significant terpene emissions when unscented wax melts were heated. The researchers also examined respiratory tract deposited dose rates (RD), a useful way of studying air pollution that measures the number of particles deposited in the respiratory tract over time. They found that the new particle formation triggered by using scented wax melts indoors produced a median RD for 1.18 to 100 nm particles of 29 billion per minute (2.9 x 1010 min-1). That's about 483 million particles per second. The majority of scented-wax-melt-formed particles were deposited in the upper airways. Their small size means they can migrate between cells and enter the bloodstream, potentially reaching organs such as the brain. The study was published in the journal Environmental Science & Technology Letters.

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Can the iPhone, AirPods, or the Apple Watch play a role in improving health? Apple says they want to find out. "In medical research, discoveries are often limited by the number of participants who can be recruited, the amount of data that can be captured, and the duration of a given study," the company said in a blog post this week. "But Apple devices expand the possibilities..." This new longitudinal, virtual study aims to understand how data from technology — including Apple and third-party devices — can be used to predict, detect, monitor, and manage changes in participants' health. Additionally, researchers will explore connections across different areas of health. CNBC reports: The new study will likely influence future product development. Apple CEO Tim Cook previously said he believes health features will be the company's "most important contribution to mankind...." The Apple Health Study will be available through the company's Research app, and participation is voluntary. Users will select each data type they are willing to share with researchers, and they can stop sharing or completely discontinue their participation at any time. Apple has no access to participants' identifiable information, the company said... The project will last at least five years and may expand beyond that. A Harvard Medical School professor and cardiologist — also a principal investigator on the Apple Health Study — says "We've only just begun to scratch the surface of how technology can improve our understanding of human health."

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A new study suggests that frequent consumption of food from plastic takeout containers significantly increases the risk of congestive heart failure due to gut biome changes that trigger inflammation and circulatory damage. The Guardian reports: The authors used a two-part approach, first looking into the frequency with which over 3,000 people in China ate from plastic takeout containers, and whether they had heart disease. They then exposed rats to plastic chemicals in water that was boiled and poured in carryout containers to extract chemicals. "The data revealed that high-frequency exposure to plastics is significantly associated with an increased risk of congestive heart failure," the authors wrote. [...] They put boiling water in the containers for one, five or 15 minutes because plastic chemicals leach at much higher rates when hot contents are placed in containers -- the study cited previous research that found as many as 4.2m microplastic particles per sq cm can leach from plastic containers that are microwaved. The authors then gave rats the water contaminated with leachate to drink for several months, then analyzed the gut biome and metabolites in the feces. It found notable changes. "It indicated that ingestion of these leachates altered the intestinal microenvironment, affected gut microbiota composition, and modified gut microbiota metabolites, particularly those linked to inflammation and oxidative stress," the authors wrote. They then checked the rats' heart muscle tissue and found it had been damaged. The study did not find a statistical difference in the changes and damage among rats that were exposed to water that had been in contact with plastic for one minute versus five or fifteen. The study has been published in the journal Ecotoxicology and Environmental Safety.

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An anonymous reader quotes a report from BleepingComputer: Hospital Sisters Health System notified over 882,000 patients that an August 2023 cyberattack led to a data breach that exposed their personal and health information. Established in 1875, HSHS works with over 2,200 physicians and has around 12,000 employees. It also operates a network of physician practices and 15 local hospitals across Illinois and Wisconsin, including two children's hospitals. The non-profit healthcare system said in data breach notifications sent to those impacted that the incident was discovered on August 27, 2023, after detecting that the attacker had gained access to HSHS' network. After the security breach, its systems were also impacted by a widespread outage that took down "virtually all operating systems" and phone systems across Illinois and Wisconsin hospitals. HSHS also hired external security experts to investigate the attack, assess its impact, and help its IT team restore affected systems. [...] While the incident and the resulting outage have all the signs of a ransomware attack, no ransomware operation has claimed the breach. Following the forensic investigation, HSHS found that the attackers had accessed files on compromised systems between August 16 and August 27, 2023. The information accessed by the threat actors while inside HSHS' systems varies for each impacted individual, and it includes a combination of name, address, date of birth, medical record number, limited treatment information, health insurance information, Social Security number, and/or driver's license number. While HSHS added that there is no evidence that the victims' information has been used in fraud or identity theft attempts, it warned affected individuals to monitor their account statements and credit reports for suspicious activity. The health system also offers those affected by the breach one year of free Equifax credit monitoring.

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An anonymous reader quotes a report from The Guardian: In the most comprehensive study of its kind, scientists have found that generally, the world feels brighter when you wake up. People start the day in the best frame of mind in the morning, but end in the worst, at about midnight, the findings suggest, with the day of the week and the season also playing a part. Mental health also tends to be more varied at weekends but steadier during the week, according to the study led by University College London. "Generally, things do seem better in the morning," the researchers concluded. Their findings were published in the journal BMJ Mental Health. [...] The results showed that happiness, life satisfaction, and worthwhile ratings were all higher on Mondays and Fridays than on Sundays, while happiness was also higher on Tuesdays. There was no evidence that loneliness differed across days of the week. There was clear evidence of a seasonal influence on mood. Compared with winter, people tended to have lower levels of depressive and anxiety symptoms and loneliness, and higher levels of happiness, life satisfaction and feeling that life was worthwhile in the three other seasons. Mental health was best in the summer across all outcomes. But the season didn't affect the associations observed across the day, however. Scientists suggest that the findings may be due to physiological changes linked to the body's circadian rhythm. Cortisol, a hormone that influences mood and motivation, peaks after waking and declines by bedtime, which may contribute to better mental health earlier in the day. Factors like sleep cycles, weather, and when participants chose to respond to the survey could have influenced the findings. There's also the differences between weekdays and weekends, which have their own variations in daily routines.

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Thursday America's FDA "raised concerns about cybersecurity vulnerabilities" in patient monitors from China-based medical device company Contec "that could allow unauthorized individuals to access and potentially manipulate those devices," reports Reuters. The patient monitors could be remotely controlled by unauthorized users or may not function as intended, and the network to which these devices are connected could be compromised, the agency warned. The FDA also said that once these devices are connected to the internet, they can collect patient data, including personally identifiable information and protected health information, and can export this data out of the healthcare delivery environment. The agency, however, added that it is currently unaware of any cybersecurity incidents, injuries, or deaths related to these identified cybersecurity vulnerabilities. The FDA's announcement says "The software on the patient monitors includes a backdoor, which may mean that the device or the network to which the device has been connected may have been or could be compromised." And it offers this advice to caregivers and patients: If your health care provider confirms that your device relies on remote monitoring features, unplug the device and stop using it. Talk to your health care provider about finding an alternative patient monitor. If your device does not rely on remote monitoring features, use only the local monitoring features of the patient monitor. This means unplugging the device's ethernet cable and disabling wireless (that is, WiFi or cellular) capabilities, so that patient vital signs are only observed by a caregiver or health care provider in the physical presence of a patient. If you cannot disable the wireless capabilities, unplug the device and stop using it. Talk to your health care provider about finding an alternative patient monitor. A detailed report from CISA describes how a research team "created a simulated network, created a fake patient profile, and connected a blood pressure cuff, SpO2 monitor, and ECG monitor peripherals to the patient monitor. Upon startup, the patient monitor successfully connected to the simulated IP address and immediately began streaming patient data..." to an IP address that hard-coded into the backdoor function. "Sensor data from the patient monitor is also transmitted to the IP address in the same manner. If the routine to connect to the hard-coded IP address and begin transmitting patient data is called, it will automatically initialize the eth0 interface in the same manner as the backdoor. This means that even if networking is not enabled on startup, running this routine will enable networking and thereby enable this functionality

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