Abstract of a paper on National Bureau of Economic Research: Physicians commonly receive marketing-related transfers from drug firms. We examine the impact of these relationships on the prescribing of physician-administered cancer drugs in Medicare. We find that prescribing of the associated drug increases 4\% in the twelve months after a payment is received, with the increase beginning sharply in the month of payment and fading out within a year. A marketing payment also leads physicians to begin treating cancer patients with lower expected mortality. While payments result in greater expenditure on cancer drugs, there are no associated improvements in patient mortality.

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SonicSpike shares a report from Scientific American: A day after the American Astronomical Society (AAS) announced that there were no signs of unsafe eclipse glasses or other solar viewers on the market in early March, astronomer and science communicator Rick Fienberg received an alarming call. Fienberg is project manager of the AAS Solar Eclipse Task Force, which is busy preparing for the total eclipse over North America on April 8. He's the creator of a list of vetted solar filters and viewers that will protect wearers' eyes as they watch the moon move in front of the sun. When a solar eclipse last crossed a major swath of the U.S. in 2017, Fienberg and his team spotted some counterfeit glasses entering the marketplace -- imitations that distributors claimed were manufactured by vetted companies. Testing at accredited labs indicated that many counterfeits were actually safe to use, however. This led the task force to describe such eclipse glasses as "misleading" but not "dangerous" in a March 11 statement meant to reassure the public. But then Fienberg's phone rang. The caller was "a guy who had bought thousands of eclipse glasses from a distributor who had been on our list at one point," Fienberg says. "Those glasses were not safe. They were no darker than ordinary sunglasses." Legitimate eclipse glasses are at least 1,000 times darker than the darkest sunglasses you can buy. Fienberg contacted Cangnan County Qiwei Craft, a Chinese factory that he knew manufactured safe glasses and had -- in the past -- sold them to the distributor in question. But this time, Fienberg says, factory representatives told him they hadn't sold to that distributor in a long while. "That's when we switched from being concerned about only counterfeits to being concerned about actual fakes," Fienberg says. The AAS does not have a confident estimate of how many fake or counterfeit glasses are for sale out there. And though Fienberg doesn't think this is a widespread problem, the situation is an "iceberg kind of concern," he says, because there are likely more examples than the ones he knows about. While counterfeit glasses may still be safe to use, completely fake glasses could put wearers in serious danger. [...] While lab tests are the best way to determine whether glasses meet the ISO standard, Fienberg says there is a three-part test people can do at home if they're concerned their eclipse viewers aren't up to the task. First, put your glasses on indoors and look around. The only things you should be able to see are very bright lights, such as a halogen bulb or a smartphone flashlight. Then, if the glasses pass the indoor test, bring them outside -- but don't look at the sun just yet. Look around: it should be too dark to see distant hills, trees or even the ground. If that second test is passed, keep the glasses on and quickly glance at the sun. You should comfortably see a bright, sharp-edged round disk. If your glasses pass all three tests, they are probably safe to wear. Still, Fienberg points out that it's best to use them for only a few seconds every minute or so during the eclipse; this cautious approach is how they're intended to be used. And if you don't trust your glasses for April's celestial event, you could try to find a reliable pair in the next two decades. "You only have to wait 20 years for another really good eclipse year in the [United] States," Fienberg says.

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An anonymous reader quotes an opinion piece from the Washington Post, published by the Editorial Board: A just-published investigation by Russian, American and German journalists has unearthed startling new information about the so-called Havana syndrome, or "Anomalous Health Incidents," as the government calls the unexplained bouts of painful disorientation that U.S. diplomats and intelligence officers have suffered in recent years. The new information suggests but does not prove that Russia's military intelligence agency is responsible. Earlier, agencies in the U.S. intelligence community had concluded that "it is very unlikely a foreign adversary is responsible." They need to look again. [...] [T]he new investigation by the Insider, a Russian investigative news outlet, in collaboration with CBS's "60 Minutes" and Germany's Der Spiegel, paints a different picture. It identifies the possible culprit as Unit 29155, a "notorious assassination and sabotage squad" of the GRU, Moscow's military intelligence service. Senior members of the unit received "awards and political promotions for work related to the development of 'non-lethal acoustic weapons'" -- a term used in the Russian military-scientific literature to describe both sound- and radiofrequency-based directed energy devices. The investigation found documentary evidence that Unit 29155 "has been experimenting with exactly the kind of weaponized technology" experts suggest is a plausible cause. Moreover, the Insider reported, geolocation data shows that operators attached to Unit 29155, traveling undercover, were present in places where Havana syndrome struck, just before the incidents took place. Even more concerning, the investigation found that a commonality among the Americans targeted was their work history on Russia issues. This included CIA officers who were helping Ukraine build up its intelligence capabilities in the years before Russia's full-scale invasion in 2022. One veteran of the CIA Kyiv station was named the new chief of station in Vietnam and was hit there. A second veteran of the CIA in Ukraine was hit in his apartment in Tashkent, Uzbekistan. Both these intelligence officers had to be medevaced and were treated at Walter Reed National Military Medical Center. The wife of a third CIA officer who had served in Kyiv was hit in London. "Of all the cases" examined by the news organizations, they said, "the most well-documented involve U.S. intelligence and diplomatic personnel with subject matter expertise in Russia or operational experience in countries such as Georgia and Ukraine," both of which were the scene of popular pro-Western uprisings in the past two decades. The news organizations point out that Russian President Vladimir Putin has often blamed these "color revolutions" on the CIA and the State Department. They conclude, "Putin would have every interest in neutralizing scores of U.S. intelligence officers he deemed responsible for his loss of the former satellites." The Editorial Board is advocating for a thorough and aggressive investigation by the U.S. intelligence community that "takes into account all aspects of the incidents." "If the incidents are a deliberate attack, the perpetrator must be identified and held to account. Along with sending a message to those who might harm American personnel, the United States needs to show all those who might join the diplomatic and intelligence services that the government will protect them abroad and at home from foreign adversaries, no matter what."

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As a department of America's federal Health agency, the Food and Drug Administration is responsible for public health rules, including prescription medicines. And the FDA "has not changed its position that currently available clinical trial data do not demonstrate that ivermectin is effective against COVID-19," they confirmed to CNN this week. "The agency has not authorized or approved ivermectin for use in preventing or treating COVID-19." But there was also a lawsuit. In "one of its more popular pandemic-era social media campaigns," the agency tweeted out "You are not a horse. You are not a cow. Seriously, y'all. Stop it." The post attracted nearly 106,000 likes — and over 46,000 reposts, and was followed by another post on Instagram. "Stop it with the #ivermectin. It's not authorized for treating #COVID." Los Angeles Times business columnist Michael Hiltzik writes that the posts triggered a "groundless" lawsuit: It was those latter two lines that exercised three physicians who had been prescribing ivermectin for patients. They sued the FDA in 2022, asserting that its advisory illegally interfered with the practice of medicine — specifically with their ability to continue prescribing the drug. A federal judge in Texas threw out their case, but the 5th Circuit Court of Appeals — the source of a series of chuckleheaded antigovernment rulings in recent years — reinstated it last year, returning it to the original judge for reconsideration. Now the FDA has settled the case by agreeing to delete the horse post and two similar posts from its accounts on the social media platforms X, LinkedIn and Facebook. The agency also agreed to retire a consumer advisory titled "Why You Should Not Use Ivermectin to Treat or Prevent COVID-19." In defending its decision, the FDA said it "has chosen to resolve this lawsuit rather than continuing to litigate over statements that are between two and nearly four years old." That sounds reasonable enough, but it's a major blunder. It leaves on the books the 5th Circuit's adverse ruling, in which a panel of three judges found that the FDA's advisory crossed the line from informing consumers, which they said is all right, to recommending that consumers take some action, which they said is not all right... That's a misinterpretation of the law and the FDA's actions, according to Dorit Rubinstein Reiss of UC College of the Law in San Francisco. "The FDA will seek to make recommendations against the misuse of products in the future, and having that decision on the books will be used to litigate against it," she observed after the settlement. "A survey by Boston University and the University of Michigan estimated that Medicare and private insurers had wasted $130 million on ivermectin prescriptions for COVID in 2021 alone."

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An anonymous reader shares a report: Thanks to the vaccination program that began in 1995, chickenpox is now relatively rare. Cases of the miserable, itchy condition have fallen more than 97 percent. But, while children have largely put the oatmeal baths and oven mitts behind them, doctors have apparently let their diagnostic skills get a little crusty. According to a study published Thursday, public health researchers in Minnesota found that 55 percent of people diagnosed with chickenpox based on their symptoms were actually negative for the varicella-zoster virus, the virus that causes chickenpox. The study noted that the people were all diagnosed in person by health care providers in medical facilities. But, instead of chickenpox, lab testing showed that some of the patients were actually infected with an enterovirus, which can cause a rash, or the herpes simplex virus 1, which causes cold sores. The study, published in the Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report, supports expanding laboratory testing for suspected chickenpox cases in the state's program and highlights that diagnoses based on symptoms are "unreliable." For one thing, doctors simply see far fewer chickenpox cases these days because of the protection from vaccines. While chickenpox cases in the US previously reached 4 million each year, with 10,500 to 13,500 hospitalizations and 100 to 150 deaths, there are now fewer than 150,000 cases,1,400 hospitalizations, and 30 deaths each year, the CDC reports. Vaccination is more than 90 percent effective at preventing the disease. In the rare cases where a vaccinated person contracts chickenpox, the muted rashes are challenging to identify by eye. But even in unvaccinated children, chickenpox can be tricky to pick out; it can easily be confused with measles, insect bites, enterovirus, skin infections such as scabies and impetigo, herpes viruses, and hand, foot, and mouth disease.

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Several readers shared the following report: Intermittent fasting, a diet pattern that involves alternating between periods of fasting and eating, can lower blood pressure and help some people lose weight, past research has indicated. But an analysis presented Monday at the American Heart Association's scientific sessions in Chicago challenges the notion that intermittent fasting is good for heart health. Instead, researchers from Shanghai Jiao Tong University School of Medicine in China found that people who restricted food consumption to less than eight hours per day had a 91% higher risk of dying from cardiovascular disease over a median period of eight years, relative to people who ate across 12 to 16 hours. It's some of the first research investigating the association between time-restricted eating (a type of intermittent fasting) and the risk of death from cardiovascular disease. The analysis -- which has not yet been peer-reviewed or published in an academic journal -- is based on data from the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey collected between 2003 and 2018. The researchers analyzed responses from around 20,000 adults who recorded what they ate for at least two days, then looked at who had died from cardiovascular disease after a median follow-up period of eight years. However, Victor Wenze Zhong, a co-author of the analysis, said it's too early to make specific recommendations about intermittent fasting based on his research alone.

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An anonymous reader quotes a report from CBC News: An array of advanced tests found no brain injuries or degeneration among U.S. diplomats and other government employees who suffer mysterious health problems once dubbed "Havana syndrome," researchers reported Monday. The National Institutes of Health's (NIH) nearly five-year study offers no explanation for symptoms including headaches, balance problems and difficulties with thinking and sleep that were first reported in Cuba in 2016 and later by hundreds of American personnel in multiple countries. But it did contradict some earlier findings that raised the spectre of brain injuries in people experiencing what the State Department now calls "anomalous health incidents." "These individuals have real symptoms and are going through a very tough time," said Dr. Leighton Chan, NIH's chief of rehabilitation medicine, who helped lead the research. "They can be quite profound, disabling and difficult to treat." Yet sophisticated MRI scans detected no significant differences in brain volume, structure or white matter -- signs of injury or degeneration -- when Havana syndrome patients were compared to healthy government workers with similar jobs, including some in the same embassy. Nor were there significant differences in cognitive and other tests, according to findings published in the Journal of the American Medical Association.

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An anonymous reader quotes a report from the BBC: The polio survivor known as "the man in the iron lung" has died at the age of 78. Paul Alexander contracted polio in 1952 when he was six, leaving him paralyzed from the neck down. The disease left him unable to breathe independently, leading doctors to place him in the metal cylinder, where he would spend the rest of his life. He would go on to earn a law degree -- and practice law -- as well as publish a memoir. [...] In 1952, when he became ill, doctors in his hometown of Dallas operated on him, saving his life. But polio meant his body was no longer able to breathe on his own. The answer was to place him in a so-called iron lung — a metal cylinder enclosing his body up to his neck. The lung, which he called his "old iron horse," allowed him to breathe. Bellows sucked air out of the cylinder, forcing his lungs to expand and take in air. When the air was let back in, the same process in reverse made his lungs deflate. After years, Alexander eventually learned to breathe by himself so that he was able to leave the lung for short periods of time. Like most polio survivors placed in iron lungs, he was not expected to survive long. But he lived for decades, long after the invention of the polio vaccine in the 1950s all but eradicated the disease in the Western world. [...] Advances in medicine made iron lungs obsolete by the 1960s, replaced by ventilators. But Alexander kept living in the cylinder because, he said, he was used to it. He was recognized by Guinness World Records as the person who lived the longest in an iron lung.

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Rates of more than a dozen cancers are increasing among adults under 50 worldwide, with the number of early-onset cancer cases predicted to rise by around 30% between 2019 and 2030. Investigators are searching for explanations, considering factors such as obesity, early-cancer screening, gut microbiome, and tumor genomes. Despite increased screening and awareness, mortality from early-onset cancers has risen by nearly 28% between 1990 and 2019 globally.

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Surgeons in the United Kingdom have performed the first operation in the country using Apple's Vision Pro headset. TechSpot reports: During a recent operation to repair a patient's spine at the private Cromwell Hospital in London, a scrub nurse working alongside the surgeon used the Vision Pro to help prepare, keep track of the procedure, and choose the right tools, reports the Daily Mail. This marked the first operation in the UK where the Vision Pro was used. The software running on Apple's headset during the operation comes from US company eXeX, which has made similar programs for Microsoft's HoloLens. It offers nurses and technicians both holographic and touch-free access to the surgical setup and the procedural guides from within the sterile field of the operating room, according to the press release. The software also tracks each stage of an operation and can measure how well the op went compared to previous procedures performed by other surgeons. "It eliminates human error and eliminates the guesswork," said Suvi Verho, lead scrub nurse at London Independent Hospital. "It gives you confidence in surgery." While this marked the first time that the Vision Pro was used during a UK surgery, the first-ever time the device was used in an operating room was last month, just three days after its release, when Orlando resident and world-renowned Neurosurgeon Dr. Robert Masson wore it during several spine reconstruction surgeries. "We are in a new era of surgery, and for the first time, our surgical teams have the brilliance of visual holographic guidance and maps, improving visuospatial and temporal orientation for each surgical team and for each surgery in all specialties," said Masson.

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An anonymous reader quotes a report from The Guardian: Doctors have warned of potentially life-threatening effects from plastic pollution after finding a substantially raised risk of stroke, heart attack and earlier death in people whose blood vessels were contaminated with microscopic plastics. Researchers in Naples examined fatty plaques removed from the blood vessels of patients with arterial disease and found that more than half had deposits contaminated with tiny particles of polyethylene or polyvinyl chloride (PVC). Those whose plaques contained microplastics or nanoplastics were nearly five times more likely to suffer a stroke, heart attack or death from any cause over the following 34 months, compared with those whose plaques were free from plastic contamination. The findings do not prove that plastic particles drive strokes and heart attacks -- people who are more exposed to the pollution may be at greater risk for other reasons -- but research on animals and human cells suggests the particles may be to blame. [...] Writing in the New England Journal of Medicine, the doctors describe how they analyzed fatty plaques removed from 304 patients with atherosclerosis affecting the carotid arteries. The carotid arteries are the main blood vessels that supply blood to the neck, face and brain. The disease causes a build-up of plaque in the arteries, which substantially raises the risk of stroke. The plaques can be removed by a procedure called carotid endarterectomy. Lab tests on the extracted plaques revealed polyethylene in 150 patients and polyvinyl chloride in 31, alongside signs of inflammation. On examination under an electron microscope, the researchers spotted jagged foreign particles in the fatty deposits, most less than a thousandth of a millimeter across. The doctors followed 257 of the patients for an average of 34 months after they had carotid plaques removed. Those who had plastic particles in their plaques were 4.5 times more likely to have a stroke or heart attack, or to die from any cause, than those whose plaques were free from plastic pollution. "People must become aware of the risks we are taking with our lifestyle," said Dr Raffaele Marfella, first author on the study at the University of Campania Luigi Vanvitelli in Naples. "I hope the alarm message from our study will raise the consciousness of citizens, especially governments, to finally become aware of the importance of the health of our planet. To put it in a slogan that can unite the need for health for humans and the planet, plastic-free is healthy for the heart and the Earth."

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