Researchers analyzing DNA from 1,313 ancient humans across Eurasia found that zoonotic pathogens first appeared in human populations around 6,500 years ago, coinciding with the transition from hunter-gatherer societies to livestock farming. The genomic study, published in Nature, identified 5,486 DNA sequences from bacteria, viruses and parasites in blood remnants from bones and teeth spanning 37,000 years. Zoonotic pathogens were detected only in remains 6,500 years old or younger, peaking around 5,000 years ago when pastoralist communities from the Steppe region migrated into Europe with large herds. The plague bacterium Yersinia pestis first appears in the dataset between 5,700-5,300 years ago.

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alternative_right shares a report from Phys.org: Researchers at Princeton University, Boston University and other institutes used machine learning to predict the strategic decisions of humans in various games. Their paper, published in Nature Human Behavior, shows that a deep neural network trained on human decisions could predict the strategic choices of players with high levels of accuracy. [...] Essentially, the team suggests that people behave more rationally while playing games that they perceive as easier. In contrast, when they are playing more complex games, people's choices could be influenced by various other factors, thus the "noise" affecting their behavior would increase. As part of their future studies, the researchers would also like to shed more light on what makes a game "complex" or "easy." This could be achieved using the context-dependent noise parameter that they integrated into their model as a signature of "perceived difficulty." "Our analysis provides a robust model comparison across a wide range of candidate models of decision-making," said [Jian-Qiao Zhu, first author of the paper]. "We now have strong evidence that introducing context-dependence into the quantal response model significantly improves its ability to capture human strategic behavior. More specifically, we identified key factors in the game matrix that shape game complexity: considerations of efficiency, the arithmetic difficulty of computing payoff differences, and the depth of reasoning required to arrive at a rational solution." The findings gathered as part of this recent study also highlight the "lightness" with which many people approach strategic decisions, which could make them vulnerable to parties looking to sway them towards making irrational decisions. Once they gather more insight into what factors make games and decision-making scenarios more challenging for people, Zhu and his colleagues hope to start devising new behavioral science interventions aimed at prompting people to make more rational decisions.

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Springer Nature published a $169 machine learning textbook in April containing citations that appear to be largely fabricated, according to an investigation by Retraction Watch. The site checked 18 of the 46 citations in "Mastering Machine Learning: From Basics to Advanced" by Govindakumar Madhavan and found two-thirds either did not exist or contained substantial errors. Three researchers contacted by Retraction Watch confirmed their supposedly authored works were fake or incorrectly cited. Yehuda Dar of Ben-Gurion University said a paper cited as appearing in IEEE Signal Processing Magazine was actually an unpublished arXiv preprint. Aaron Courville of Universite de Montreal confirmed he was cited for sections of his "Deep Learning" book that "doesn't seem to exist." The pattern of nonexistent citations matches known hallmarks of large language model-generated text. Madhavan did not answer whether he used AI to generate the book's content. The book contains no AI disclosure despite Springer Nature policies requiring authors to declare AI use beyond basic copy editing.

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"Citizen scientists have successfully located thousands of previously unknown pairs of 'eclipsing binary' stars," reports the Washington Post, citing a recent announcement from NASA. The ongoing initiative helps space researchers hunt for "eclipsing binary" stars, a rare phenomenon in which two stars orbit one another, periodically blocking each other's light. These star pairs offer important data to astrophysicists, who consider the many measurable properties of eclipsing binaries — and the information they bear about the history of star formation and destruction — as a foundation of the field... The citizen science project in question, the Eclipsing Binary Patrol, validates images from NASA's Transiting Exoplanet Survey Satellite (TESS) mission. The satellite, launched in 2018, is "exceptionally capable at detecting varying stars," the researchers write in a preprint paper describing the initiative. The researchers used machine learning to identify about 1.2 million potential eclipsing star pairs. Citizen scientists then validated a subset of about 60,000... manually inspecting hundreds of thousands of images of eclipse-like events and weeding out actual binaries from images that tricked the algorithm. "Thankfully," the researchers write, "to the rescue come volunteers from all walks of life that boost the capacity of bandwidth-limited professional astronomers many-fold and help tackle the ever-increasing volume of publicly available astronomical data." Universe Today describes how they limited the dataset to only stars with a magnitude brighter than 15, then used a Python tool to generate a massive dataset of millions of light curves... The outcome of all the work resulted in the identification of 10,001 eclipsing binary systems. 7,936 of them are new to science, while the other 2,065 were previously known, but the study provided updated, more accurate, parameters for their periods, as TESS' dataset provided better insight. There were also some particularly interesting systems that could hold new discoveries, including several that had variable eclipse timings, and plenty that might have a third star, and some that show a significant dynamic between the star being orbited and the one doing the orbiting. All of those systems await further research, but there's another, unspoken factor at play in this data — exoplanets. TESS was originally designed as an exoplanet hunter, and this kind of large scale AI/human collaboration of lightcurve analysis is exactly the kind of work that could potentially produce even more accurate exoplanet catalogues, as evidenced by some of the work already done in this paper. That seems to be the next step for this dataset, with Dr. Kostov telling an interviewer "I can't wait to search them for exoplanets!" Given the data has already been collected, and the team has already been assembled, it's very likely he'll get his chance soon.

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"Some of our basic assumptions about the biological process of aging might be wrong," reports the New York Times — citing new research on a small Indigenous population in the Bolivian Amazon. [Alternate URL here.] Scientists have long believed that long-term, low-grade inflammation — also known as "inflammaging" — is a universal hallmark of getting older. But this new data raises the question of whether inflammation is directly linked to aging at all, or if it's linked to a person's lifestyle or environment instead. The study, which was published Monday, found that people in two nonindustrialized areas experienced a different kind of inflammation throughout their lives than more urban people — likely tied to infections from bacteria, viruses and parasites rather than the precursors of chronic disease. Their inflammation also didn't appear to increase with age. Scientists compared inflammation signals in existing data sets from four distinct populations in Italy, Singapore, Bolivia and Malaysia; because they didn't collect the blood samples directly, they couldn't make exact apples-to-apples comparisons. But if validated in larger studies, the findings could suggest that diet, lifestyle and environment influence inflammation more than aging itself, said Alan Cohen, an author of the paper and an associate professor of environmental health sciences at Columbia University. "Inflammaging may not be a direct product of aging, but rather a response to industrialized conditions," he said, adding that this was a warning to experts like him that they might be overestimating its pervasiveness globally. "How we understand inflammation and aging health is based almost entirely on research in high-income countries like the U.S.," said Thomas McDade, a biological anthropologist at Northwestern University. But a broader look shows that there's much more global variation in aging than scientists previously thought, he added... McDade, who has previously studied inflammation in the Tsimane group, speculated that populations in nonindustrialized regions might be exposed to certain microbes in water, food, soil and domestic animals earlier in their lives, bolstering their immune response later in life. More from The Independent: Chronic inflammation is thought to speed up the ageing process and contribute to various health conditions such as Alzheimer's disease, arthritis, cancer, heart disease, and Type 2 diabetes... However, other experts shared a word of caution before jumping to conclusions from the study. Vishwa Deep Dixit, director of the Yale Center for Research on Aging, told the New York Times it's not surprising that people less exposed to pollution would see lower rates of chronic disease. Aurelia Santoro, an associate professor at the University of Bologna, also cautioned about the results, according to the Times. "While they had lower rates of chronic disease, the two Indigenous populations tended to have life spans shorter than those of people in industrialized regions, meaning they may simply not have lived long enough to develop inflammaging, Santoro said." And Bimal Desai, a professor of pharmacology who studies inflammation at the University of Virginia School of Medicine, told the Times that the study "sparks valuable discussion" but needs more follow-up "before we rewrite the inflammaging narrative."

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Science Daily reports: Wild orcas across four continents have repeatedly floated fish and other prey to astonished swimmers and boaters, hinting that the ocean's top predator likes to make friends. Researchers cataloged 34 such gifts over 20 years, noting the whales often lingered expectantly — and sometimes tried again — after humans declined their offerings, suggesting a curious, relationship-building motive... "Orcas often share food with each other — it's a prosocial activity and a way that they build relationships with each other," said study lead author Jared Towers, of Bay Cetology in British Columbia, Canada. "That they also share with humans may show their interest in relating to us as well." The complete research was published in the Journal of Comparative Psychology. Its title? "Testing the Waters: Attempts by Wild Killer Whales (Orcinus orca) to Provision People (Homo sapiens)."

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A new study analyzing data from more than 60 previous research projects has found evidence that there is "no safe amount" of processed meat consumption -- so much so that even small daily portions are being linked to increased disease risk. The research, published Monday in the journal Nature Medicine, examined connections between processed meats, sugar-sweetened beverages and trans fatty acids and the risk of type 2 diabetes, colorectal cancer and ischemic heart disease. People who ate as little as one hot dog daily showed an 11% greater risk of type 2 diabetes and 7% increased risk of colorectal cancer compared to those who consumed none. Drinking approximately one 12-ounce soda per day was associated with an 8% increase in type 2 diabetes risk and 2% increased risk of ischemic heart disease.

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Air pollution has been linked to a swathe of lung cancer-driving DNA mutations, in a study of people diagnosed with the disease despite never having smoked tobacco. From a report: The findings from an investigation into cancer patients around the world helps explain why those who have never smoked make up a rising proportion of people developing the cancer, a trend the researchers called an "urgent and growing global problem." Prof Ludmil Alexandrov, a senior author on the study at the University of California in San Diego, said researchers had observed the "problematic trend" but had not understood the cause. "Our research shows that air pollution is strongly associated with the same types of DNA mutations we typically associate with smoking," he said. The scientists analyzed the entire genetic code of lung tumors removed from 871 never-smokers in Europe, North America, Africa and Asia as part of the Sherlock-Lung study. They found that the higher the levels of air pollution in a region, the more cancer-driving and cancer-promoting mutations were present in residents' tumors. Fine-particulate air pollution was in particular linked to mutations in the TP53 gene. These have previously been associated with tobacco smoking.

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Le Palais de la Découverte c’est ce lieu magique ou la science rencontre l’enfance. Un endroit qui transforme la magie du monde en faits, en états et en lois physiques. À une époque où les enfants sont en manque de repères, où plus personne ne semble distinguer le vrai du faux, cet endroit de partage du savoir emblématique est menacé.

Alors que de nombreuses études montrent un désintérêt pour les sciences, que les filles sont moins représentées que les garçons dans ces filières et que les défis scientifiques à venir sont monstrueux à cause du changement climatique. Le Palais de la Découverte est en grave danger. Ce lieu de transmission important, de prise de conscience de notre monde et visité en grande majorité par des non-parisiens pourrait être expulsé du Grand Palais. Ce qui signifierait probablement sa mise à mort juste après des années de fermeture et de reconstruction pour la mise à jour de son espace.

Vous pouvez agir simplement en signant la pétition ouverte sur Change.org. Montrer que la science et le partage de celle-ci ne sont pas des sous produits culturels, mais une part importante de notre passé comme de notre futur. Que ce lieu prestigieux qu’est le Grand Palais n’a pas pour unique vocation qu’à être privatisé pour des évènements commerciaux, mais se doit d’accueillir la science. Que le partage de la connaissance scientifique est tout aussi important que la couteuse célébration des Jeux Olympiques.

Pour signer la pétition, vous pouvez aller sur Change.org. Cela ne prend que quelques minutes de signer et de valider ensuite votre signature par email.

Sauvez le Palais de la Découverte ! © MiniMachines.net. 2025

A new study challenges previous research about which sleep stages help people achieve breakthrough moments in problem-solving. Researchers found that N2 sleep, a deeper stage of non-REM sleep, significantly increased participants' likelihood of experiencing sudden insights during a perceptual task. The preregistered study involved 90 participants who performed a visual pattern recognition task before and after a 20-minute daytime nap while researchers monitored their brain activity with EEG. Participants who reached N2 sleep showed an 85.7% rate of achieving insights about a hidden strategy in the task, compared to 63.6% for those who only reached N1 sleep (the first stage of non-rapid eye movement sleep) and 55.5% for participants who remained awake. The findings contradict earlier work by Lacaux and colleagues, which suggested that lighter N1 sleep promoted insight while deeper sleep hindered it. News coverage: Stuck on a problem? Take a nap!

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alternative_right shares a report from Phys.Org: In new research published by scientists studying fission yeastâ"a single-celled organism surprisingly similar to human cellsâ"researchers found that caffeine affects aging by tapping into an ancient cellular energy system. A few years ago, the same research team found that caffeine helps cells live longer by acting on a growth regulator called TOR (target of rapamycin). TOR is a biological switch that tells cells when to grow, based on how much food and energy is available. This switch has been controlling energy and stress responses in living things for over 500 million years. But in their latest study, the scientists made a surprising discovery: Caffeine doesn't act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans. "When your cells are low on energy, AMPK kicks in to help them cope," explains Dr. Charalampos (Babis) Rallis, Reader in Genetics, Genomics and Fundamental Cell Biology at Queen Mary University of London, the study's senior author. "And our results show that caffeine helps flip that switch." Interestingly, AMPK is also the target of metformin, a common diabetes drug that's being studied for its potential to extend human lifespan together with rapamycin. Using their yeast model, the researchers showed that caffeine's effect on AMPK influences how cells grow, repair their DNA, and respond to stress -- all of which are tied to aging and disease. The study has been published in the journal Microbial Cell.

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More than 110 million people across Europe suffer high levels of health-damaging noise pollution, according to a report. The resulting physiological stress and sleep disturbance leads to 66,000 early deaths a year and many cases of heart disease, diabetes and depression. The Guardian: The report, from the European Environment Agency (EEA), focuses on noise from cars, trains and aeroplanes and found that 20% of the population of the European Economic Area (EEA) were affected. Separate research, using a slightly lower threshold for dangerous noise pollution, found that 40% of the UK population were exposed to harmful transport noise. Seventeen million people endure particularly high noise pollution -- "long-term, high-annoyance" -- and almost 5 million suffer "severe" sleep disturbance. Fifteen million children live in areas of harmful noise. The harm to health from noise is greater than that from higher-profile risks including secondhand tobacco smoke or lead exposure, and incurs an economic cost of almost $116bn a year, the analysis found. The damage to health is likely to be an underestimate, the researchers said. Using the World Health Organization's stricter threshold for risky noise pollution gives an estimate of 150 million people across Europe exposed. The EU's target to cut the number of people chronically disturbed by transport noise by 30% by 2030 will not be met without further action, the researchers said.

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Bacteria can be used to turn plastic waste into painkillers, researchers have found, opening up the possibility of a more sustainable process for producing the drugs. From a report: Chemists have discovered E coli can be used to create paracetamol, also known as acetaminophen, from a material produced in the laboratory from plastic bottles. "People don't realise that paracetamol comes from oil currently," said Prof Stephen Wallace, the lead author of the research from the University of Edinburgh. "What this technology shows is that by merging chemistry and biology in this way for the first time, we can make paracetamol more sustainably and clean up plastic waste from the environment at the same time." Writing in the journal Nature Chemistry, Wallace and colleagues report how they discovered that a type of chemical reaction called a Lossen rearrangement, a process that has never been seen in nature, was biocompatible. In other words, it could be carried out in the presence of living cells without harming them. The team made their discovery when they took polyethylene terephthalate (PET) -- a type of plastic often found in food packaging and bottles -- and, using sustainable chemical methods, converted it into a new material.

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Microplastics are present in all beverages, but those packaged in glass bottles contain more microplastic particles than those in plastic bottles, cartons or cans. This was the surprising finding of a study conducted by the Boulogne-sur-Mer unit of the ANSES Laboratory for Food Safety. The scientists hypothesised that these plastic particles could come from the paint used on bottle caps. Water and wine are less affected than other beverages. These findings have highlighted a source of microplastics in drinks that manufacturers can easily take measures to address.

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alternative_right writes: We certainly weren't looking for it. What we have confirmed is that metals have their own intrinsic, natural ability to heal themselves, at least in the case of fatigue damage at the nanoscale.' While the observation is unprecedented, it's not wholly unexpected. In 2013, Texas A&M University materials scientist Michael Demkowicz worked on a study predicting that this kind of nanocrack healing could happen, driven by the tiny crystalline grains inside metals essentially shifting their boundaries in response to stress... That the automatic mending process happened at room temperature is another promising aspect of the research. Metal usually requires lots of heat to shift its form, but the experiment was carried out in a vacuum; it remains to be seen whether the same process will happen in conventional metals in a typical environment. A possible explanation involves a process known as cold welding, which occurs under ambient temperatures whenever metal surfaces come close enough together for their respective atoms to tangle together. Typically, thin layers of air or contaminants interfere with the process; in environments like the vacuum of space, pure metals can be forced close enough together to literally stick.

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ScienceAlert reports: Casino lighting could be nudging gamblers to be more reckless with their money, according to a new study, which found a link between blue-enriched light and riskier gambling behavior. The extra blue light emitted by casino decor and LED screens seems to trigger certain switches in our brains, making us less sensitive to financial losses compared to gains of equal magnitude, researchers from Flinders University and Monash University in Australia found... The researchers think circadian photoreception, which is our non-visual response to light, is playing a part here. The level of blue spectrum light may be activating specific eye cells connected to brain regions in charge of decision-making, emotional regulation, and processing risk versus reward scenarios. "Under conditions where the lighting emitted less blue, people tended to feel a $100 loss much more strongly than a $100 gain — the loss just feels worse," [says the study's lead author, a psychologist at the Flinders Health and Medical Research Institute]. "But under bright, blue-heavy light such as that seen in casino machines, the $100 loss didn't appear to feel as bad, so people were more willing to take the risk...." That raises some questions around ethics and responsibility, according to the researchers. While encouraging risk taking might be good for the gambling business, it's not good for the patrons spending their cash. One professor involved in the study reached this conclusion. "It is possible that simply dimming the blue in casino lights could help promote safer gambling behaviors." The research has been published in Scientific Reports. Thanks to Slashdot reader alternative_right for sharing the news.

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alternative_right shares a report from ScienceAlert: A team of biologists from Northeastern University and the University of Kentucky has found one of the key molecules involved in axolotl regeneration. It's a crucial component in ensuring the body grows back the right parts in the right spot: for instance, growing a hand, from the wrist. "The cells can interpret this cue to say, 'I'm at the elbow, and then I'm going to grow back the hand' or 'I'm at the shoulder... so I'm going to then enable those cells to grow back the entire limb'," biologist James Monaghan explains. That molecule, retinoic acid, is arranged through the axolotl body in a gradient, signaling to regenerative cells how far down the limb has been severed. Closer to the shoulder, axolotls have higher levels of retinoic acid, and lower levels of the enzyme that breaks it down. This ratio changes the further the limb extends from the body. The team found this balance between retinoic acid and the enzyme that breaks it down plays a crucial role in 'programming' the cluster of regenerative cells that form at an injury site. When they added surplus retinoic acid to the hand of an axolotl in the process of regenerating, it grew an entire arm instead. In theory, the human body has the right molecules and cells to do this too, but our cells respond to the signals very differently, instead forming collagen-based scars at injury sites. Next, Monaghan is keen to find out what's going on inside cells -- the axolotl's, and our own -- when those retinoic acid signals are received. The research is published in Nature Communications.

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Nature will automatically publish peer review reports and author responses alongside all newly submitted research papers starting this week. The flagship scientific journal previously offered transparent peer review as an optional service since 2020, while Nature Communications has required it since 2016. All exchanges between authors and anonymous reviewers will become publicly accessible (reviewer identities remain confidential unless they choose disclosure). Nature aims to open what it calls the "black box" of science by revealing the months-long conversations that shape research papers before publication.

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sciencehabit shares a report from Science.org: The newly discovered microbe provisionally known as Sukunaarchaeum isn't a virus. But like viruses, it seemingly has one purpose: to make more of itself. As far as scientists can tell from its genome -- the only evidence of its existence so far -- it's a parasite that provides nothing to the single-celled creature it calls home. Most of Sukunaarchaeum's mere 189 protein-coding genes are focused on replicating its own genome; it must steal everything else it needs from its host Citharistes regius, a dinoflagellate that lives in ocean waters all over the world. Adding to the mystery of the microbe, some of its sequences identify it as archaeon, a lineage of simple cellular organisms more closely related to complex organisms like us than to bacteria like Escherichia coli. The discovery of Sukunaarchaeum's bizarrely viruslike way of living, reported last month in a bioRxiv preprint, "challenges the boundaries between cellular life and viruses," says Kate Adamala, a synthetic biologist at the University of Minnesota Twin Cities who was not involved in the work. "This organism might be a fascinating living fossil -- an evolutionary waypoint that managed to hang on." Adamala adds that if Sukunaarchaeum really does represent a microbe on its way to becoming a virus, it could teach scientists about how viruses evolved in the first place. "Most of the greatest transitions in evolution didn't leave a fossil record, making it very difficult to figure out what were the exact steps," she says. "We can poke at existing biochemistry to try to reconstitute the ancestral forms -- or sometimes we get a gift from nature, in the form of a surviving evolutionary intermediate." What's already clear: Sukunaarchaeum is not alone. When team leader Takuro Nakayama, an evolutionary microbiologist at Tsukuba, and his colleagues sifted through publicly available DNA sequences extracted from seawater all over the world, they found many sequences similar to those of Sukunaarchaeum. "That's when we realized that we had not just found a single strange organism, but had uncovered the first complete genome of a large, previously unknown archaeal lineage," Nakayama says.

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alternative_right shares a report from ScienceDaily: When the brain is under pressure, certain neural signals begin to move in sync -- much like a well-rehearsed orchestra. A new study from Johannes Gutenberg University Mainz (JGU) is the first to show how flexibly this neural synchrony adjusts to different situations and that this dynamic coordination is closely linked to cognitive abilities. "Specific signals in the midfrontal brain region are better synchronized in people with higher cognitive ability -- especially during demanding phases of reasoning," explained Professor Anna-Lena Schubert from JGU's Institute of Psychology, lead author of the study recently published in the Journal of Experimental Psychology: General. The researchers focused on the midfrontal area of the brain and the measurable coordination of the so-called theta waves. These brainwaves oscillate between four and eight hertz and belong to the group of slower neural frequencies. "They tend to appear when the brain is particularly challenged such as during focused thinking or when we need to consciously control our behavior," said Schubert, who heads the Analysis and Modeling of Complex Data Lab at JGU. The 148 participants in the study, aged between 18 and 60, first completed tests assessing memory and intelligence before their brain activity was recorded using electroencephalography (EEG). [...] As a result, individuals with higher cognitive abilities showed especially strong synchronization of theta waves during crucial moments, particularly when making decisions. Their brains were better at sustaining purposeful thought when it mattered most. "People with stronger midfrontal theta connectivity are often better at maintaining focus and tuning out distractions, be it that your phone buzzes while you're working or that you intend to read a book in a busy train station," explained Schubert. The findings have been published in the Journal of Experimental Psychology.

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