La branche logicielle du groupe français de défense a annoncé jeudi 23 juillet le rachat au suédois Nordic Capital de la plateforme américaine d’intelligence artificielle consacrée à la biotech ArisGlobal. Une façon de renforcer sa présence sur le marché convoité des sciences de la vie.

© PHOTO Sarah Meyssonnier/REUTERS

AleRunner writes: The first fully synthetic cell ("SpudCell") has been created in the Department of Genetics at the University of Minnesota. Strictly speaking, it's described as a "cell-like system constructed entirely from known chemical components that can perform a complete cell cycle." It is able to replicate, but only for approximately five generations. The key advance is that the cell is "built entirely bottom-up from individually purified, non-living components," although it still contains material from E. coli bacteria. "PURE is a defined mixture of 36 purified enzymes from E. coli bacteria," including ribosomes, that provides the infrastructure for genetic replication. CNN has an article on the advance, including interview material with Professor Kate Adamala, who led the research. "I know the full ingredient list of the cell. I know exactly what chemicals, what molecules, at what concentrations," she said. "It is fully defined, which means we can engineer it." "Humans did not create life," notes an anonymous Slashdot reader. "Researchers call it a constructed cell, not 'life created in the lab' but a 'genuine milestone on the road toward that question.' It lacks full autonomy (needs feeding, no independent evolution)." Special thanks to Slashdot readers kemosabi and AleRunner for submitting the story and additional sources, including reports from The New York Times and The Guardian, as well as information from the University of Minnesota Twin Cities.

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Jeff Bezos is backing Flourish, a new "neuro AI" startup with $500 million in funding and a reported $2.5 billion valuation, that aims to reinvent AI by studying the brain's architecture and building systems that learn continuously while using far less power than today's large language models. The company's long-term bet is that neuroscientists and AI researchers working together can uncover the brain's "core algorithm" and eventually create brain-inspired AI that runs on a tiny fraction of current compute. Wired reports: Rob Williams knows how to pitch Jeff Bezos: You write a press release as if your product has already been built. Bezos reads it and gives a thumbs up or down. Williams went through this process a lot as an executive on Amazon's "S-team," in charge of software products such as Alexa, until his departure last fall. But the pitch he made a few weeks later -- in December 2025 -- was different. Now he was collaborating with Thomas Reardon, a neuroscientist and repeat startup founder, and approaching Bezos as a funder, not a boss. Here's what Bezos, sitting on his yacht somewhere, read while Williams anxiously watched on Zoom: "Flourish is a neuro AI company that is solving the two most difficult problems facing AI today: power efficiency and continuous learning. We are building Cortex AI, the first synthetic intelligence system designed to match the computational capacity, learning efficiency, and power budget of the human brain." A month later, I'm lunching with Reardon and Williams in the Flatiron neighborhood in New York City. Reardon gets right to the point. AI has dug itself into a hole, he says. Though increasingly powerful, large language models are greedy consumers of computer power and data. Though the inspiration for LLMs was rooted in biology, current frontier models have little in common with the human brain. A person uses about 20 watts of energy to process information; a single chip in an AI training cluster uses more than 30 times that amount. The hyperscalers require thousands of chips and gigawatts of energy, enough to power small cities. And those models need to suck up virtually all of what humans have written. Each new model requires more, more, more. For all of that, the models don't learn. Once you train them, they're stuck. The goal, Reardon tells me, is to build "a synthetic artificial intelligence brain that runs on 50 watts or less." It should adapt to its conditions, be as nimble as a human mind, and burn a tiny fraction of an LLM's compute power and energy. The proof of concept is thriving inside our skulls. "There's something fundamentally wrong with saying, "I need to basically read every book ever written 20 times over in order to learn English,'" Reardon says. "A human baby does it with a couple hundred thousand utterances." Reardon and Williams haven't figured out yet how to build systems that match the magic of a human brain. What they have is a belief that an expert, well-resourced team -- of AI researchers and neuroscientists working essentially side by side -- can find the answer. The neuroscientists will conduct original wet lab experiments with some of the most advanced lab equipment available, to hunt for usable intel on the brain's architecture. They plan to release the models they're currently developing as near-term products on the path to a full reinvention of AI. The fuzziness of the proposal didn't bother Jeff Bezos. After reading Williams' two-pager, he chipped in $50 million. Other funding came from Lux Capital, Google Ventures, and Catalio, among others. Bezos then almost doubled his initial stake and told Reardon he'd have given more if they'd asked. Now with a war chest of $500 million and a reported valuation of $2.5 billion, Flourish just needs to invent a new way to do AI.

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"A DNA-editing feat involving editing the genes of early stage embryos was announced this week," reports the Wall Street Journal. They describe the feat as "a far cry from designer babies, but nevertheless a step in that direction." Dieter Egli, an associate professor of developmental cell biology at Columbia University and his co-authors, including Nathan Treff of Nucleus Genomics, a New York-based DNA-testing startup, say the technology could help fix disease-causing mutations in embryos. "We're not throwing the final 'OK, you will have gene-edited babies tomorrow' at the public," said Egli. "That is a process that can occur through discussion matched with scientific progress...." Previous gene-editing efforts have often used Crispr, which can cut out parts of the DNA sequence, but the technology can also cause damage if the wrong DNA is targeted or cut out. In 2018, Chinese scientist He Jianku said he used Crispr to tweak DNA in human embryos and was imprisoned for the work. The technology Egli's group used, called base editing, allows them to target individual DNA letters in sequences more precisely with fewer adverse effects... Egli's group focused on altering two genes, one that can raise the risk of heart disease and one that is tied to blood disorders like sickle cell disease, and the research showed they were sometimes able to do so successfully, in the same embryo, without damage. "I am generally supportive of the concept of embryo editing to prevent genetic disease," said Dr. Paula Amato, a fertility expert at Oregon Health & Science University who wasn't involved in the research... Base editing has been used in human embryos before, according to peer-reviewed studies. The technology was used to correct a disease-causing mutation and an Alzheimer's disease-risk gene variant, said Alexis Komor, associate professor of biochemistry and molecular biophysics at the University of California, San Diego, who wasn't involved in the work. "There really is not any unmet medical or clinical need for this, especially from an in vitro fertilization perspective," Komor said. "Usually what you'll hear is that they're doing it just so that you know we can prevent genetic diseases, but there are so many other better ways to do that." Using embryo editing to create babies is illegal in the U.S. and many other countries. Scientists have long worried that it is a slippery slope and that the technology could ultimately be used to promote eugenics. Her worry is that "they're basically building a blueprint" for more ethically problematic forms of embryo editing. "In my opinion, I think this is a huge no-no," Komor said. "There's just no ethical way to use this...." Nucleus Genomics Chief Executive Kian Sadeghi said his company plans to fund Egli's further research, building on the new findings. His company sells a polygenic embryo-screening product, which screens prospective parents' embryos and produces risk scores for their likelihood of developing disease, as well as factors like height, IQ and eye color. The company has said the IQ predictions are limited in accuracy. The research was published online Monday on a preprint server.

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Scientists "have made a discovery that may help prevent some people from developing lung cancer," reports the New York Times, noting that lung cancer "kills more people worldwide than any other cancer." A team of more than 80 researchers working across four continents have identified a set of proteins in the blood that accurately predict lung cancers more than five years before diagnosis. The scientists also found early evidence that an existing anti-inflammatory drug could significantly reduce lung cancer risk in people with elevated concentrations of these proteins, which they linked to inflammation. More research is needed before a test based on these proteins could be ready for use in patients. And scientists would still need to run a randomized trial to determine whether the drug prevents lung cancers. Still, outside experts said the findings, which were published on Thursday in the journal Cell, offer a promising starting point toward a long-held public health goal... Led by Dr. Swanton, Dr. Tej Pandya, a Ph.D. student, and other researchers took a set of 48,000 blood samples from the UK Biobank and used machine learning to identify 14 proteins associated with the development of lung cancer. When the researchers looked at the presence of those proteins and also took into account a patient's age, smoking status and history of lung disease, they were able to predict who would develop lung cancer more accurately than the best risk assessment models currently in use... Using mouse and cell models, the scientists showed that these proteins increased when a specific inflammatory pathway was activated. Smoking and air pollution can activate that pathway. This adds to the evidence that it isn't just genetic mutations caused by smoking, pollution or other factors that are driving lung cancers. Rather, Dr. Swanton said, the findings suggest that "smoke causes mutations and inflammation, which together cause cancer." They also found that the signature was increased in people who later developed chronic obstructive pulmonary disease and pulmonary fibrosis, pointing to a common inflammatory environment upstream of all three diseases.

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"Think Olympics on steroids. Literally," quips the BBC, describing Sunday's controversial Enhanced Games event in Las Vegas featuring dozens of athletes "using performance-enhancing drugs to try and break world records in track, weightlifting and swimming. Some $25m (£18.6m) in prize money is up for grabs — with cash prizes for winners... The drugs they use must be legal, and approved by the Federal Drug Administration. But substances like testosterone and human growth hormone — banned by the World Anti-Doping Agency — are not only celebrated here, they're encouraged and for sale... Health experts warn that anabolic steroids and growth hormones can cause strokes and cardiovascular damage, among other risks. Event organisers claim Enhanced will push the limits of human performance while critics, especially in the Olympic movement, dismiss it as an affront to the spirit and founding principles of competitive sport... Earlier this month, the Enhanced Group — the company behind the competition — began trading on the New York Stock Exchange. And the competition is seemingly being treated as an opportunity for Enhanced to sell performance-enhancing medicine and supplements online. "The project was founded by entrepreneurs Aron D'Souza and Maximilian Martin in 2023," the artidcle points out, "and has attracted backing from prominent investors including billionaire Peter Thiel and Donald Trump Jr." And NPR adds that "Most of the participating athletes trained for the competition in Abu Dhabi, as part of Enhanced's own study." Enhanced did not break down what specific athletes used which drugs, but they announced on Wednesday in the lead-up to the event that 91% of the athletes competing used testosterone or testosterone esters, 79% used human growth hormone, and 62% used stimulants, such as adderall... The games have been largely panned by outside medical experts and sports governing bodies. Multiple recent studies assess the harm surrounding the Enhanced Games. Travis Tygart, the CEO of the U.S. Anti-Doping Agency, called the games a "dangerous clown show that puts profit over principle" in a statement. The International Olympic Committee said the games are a "betrayal of everything that we stand for." The World Anti-Doping Agency (WADA) last year urged U.S. authorities to stop the games. The International Federation of Sports Medicine said in 2024 that they see the medical oversight as "insufficient" to support the athletes.

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Colossal Biosciences says it has grown chickens inside 3D-printed artificial eggshells. "The company says the egg technology could help conserve at-risk bird species," reports MIT Technology. "It could also play a role in a project to re-create the extinct giant moa, a flightless 12-foot-tall bird that once lived in New Zealand and laid four-liter eggs, larger than those of any living bird." From the report: The biotech company today claimed it has developed a "fully artificial egg" as part of its effort to resurrect extinct avian species, including birds like the dodo and the giant moa. But "artificial eggshell" would probably be a better description for the invention. It's an oval-shaped printed lattice, coated inside with a special silicone-based membrane that lets in oxygen, just as a real eggshell does. To generate birds, Colossal took recently laid chicken eggs and carefully poured their contents into the artificial shells, where they continued growing. A window on top lets researchers peek inside. "To see them all moving around in their artificial eggs was absolutely mind blowing," says Andrew Pask, the company's chief biology officer. "You really feel you can grow life outside of the womb." [...] The work on the artificial eggshell was carried out in Dallas by Colossal's exogenous development team, or Exo Dev. That group is also trying to develop artificial wombs for mammals, starting with marsupials. "We're looking at every single facet of what's happening during a mammalian pregnancy to unpack exactly how we then go about recapitulating that," says Pask. For that team, an artificial eggshell is a relatively quick and easy technical win. That's because chickens are already an example of ex utero development. After an egg is laid, a small embryo sitting on top of the yolk starts growing, drawing nutrients from the yolk, the white, and even the shell, which provides calcium. (Colossal says it has to add ground-up calcium to the artificial eggs.) In order to create a moa, Colossal will have to genetically alter another type of bird, changing potentially thousands of DNA letters. But so far, chickens are the only bird species that can be genetically engineered. And that's via a tricky process of editing stem cells that produce egg and sperm. Scientists have to add or delete DNA letters from these cells and then inject them back into an egg. The resulting bird will carry the genetic changes in its gonads -- and then be able to pass them on. Pask says Colossal's idea is that it could modify avian stem cells enough to produce moa-like sperm or eggs. But then you might have the odd situation of a chicken laying an egg with a moa embryo inside it. "You would have chickens making moa egg and moa sperm. But it's still a chicken egg," he says.

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