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Fidelity Customers' Financial Info Feared Stolen In Suspected Ransomware Attack

Par : BeauHD
6 mars 2024 à 22:20
An anonymous reader quotes a report from The Register: Criminals have probably stolen nearly 30,000 Fidelity Investments Life Insurance customers' personal and financial information -- including bank account and routing numbers, credit card numbers and security or access codes -- after breaking into Infosys' IT systems in the fall. According to Fidelity, in documents filed with the Maine attorney general's office, miscreants "likely acquired" information about 28,268 people's life insurance policies after infiltrating Infosys. "At this point, [Infosys] are unable to determine with certainty what personal information was accessed as a result of this incident," the insurer noted in a letter [PDF] sent to customers. However, the US-headquartered firm says it "believes" the data included: names, Social Security numbers, states of residence, bank accounts and routing numbers, or credit/debit card numbers in combination with access code, password, and PIN for the account, and dates of birth. In other words: Potentially everything needed to drain a ton of people's bank accounts, pull off any number of identity theft-related scams -- or at least go on a massive online shopping spree. LockBit claimed to be behind the Infosys intrusion in November, shortly after the Indian tech services titan disclosed the "cybersecurity incident" affecting its US subsidiary, Infosys McCamish Systems aka IMS. It reported that the intrusion shuttered some of its applications and IT systems [PDF]. This was before law enforcement shut down at least some of LockBit's infrastructure in December, although that's never a guarantee that the gang will slink off into obscurity -- as we're already seen. "Since learning of this event, we have been engaged with IMS to understand IMS's actions to investigate and contain the event, implement remedial measures, and safely restore its services," Fidelity assured its customers. "In addition, we remain engaged with IMS as they continue their investigation of this incident and its impact on the data they maintain."

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Waymo Launches Driverless Rides For Employees In Austin

Par : BeauHD
6 mars 2024 à 23:00
Waymo announced that it will begin shuttling employees around 43 square miles of Austin, Texas, including the Barton Hills, Riverside, East Austin and Hyde Park neighborhoods, as well as downtown Austin. As TechCrunch notes, it's "a crucial step before the company opens the program up to the public." From the report: The step forward comes just a few days after Waymo won the ability to start charging for rides in expanded territory across both Los Angeles and the San Francisco Bay Area. Waymo didn't offer a timeline for when it plans to start offering autonomous rides to the citizens of Austin. When it does, it will become the fourth city where the company's robotaxis are officially in operation, following LA, SF and Phoenix.

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Public Trust In AI Is Sinking Across the Board

Par : BeauHD
6 mars 2024 à 23:40
Trust in AI technology and the companies that develop it is dropping, in both the U.S. and around the world, according to new data from Edelman shared first with Axios. Axios reports: Globally, trust in AI companies has dropped to 53%, down from 61% five years ago. In the U.S., trust has dropped 15 percentage points (from 50% to 35%) over the same period. Trust in AI is low across political lines. Democrats trust in AI companies is 38%, independents are at 25% and Republicans at 24%. Tech is losing its lead as the most trusted sector. Eight years ago, technology was the leading industry in trust in 90% of the countries Edelman studies. Today, it is the most trusted in only half of countries. People in developing countries are more likely to embrace AI than those in developed ones. Respondents in France, Canada, Ireland, UK, U.S., Germany, Australia, the Netherlands and Sweden reject the growing use of AI by a three-to-one margin, Edelman said. By contrast, acceptance outpaces resistance by a wide margin in developing markets such as Saudi Arabia, India, China, Kenya, Nigeria and Thailand. "When it comes to AI regulation, the public's response is pretty clear: 'What regulation?'," said Edelman global technology chair Justin Westcott. "There's a clear and urgent call for regulators to meet the public's expectations head on."

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Google Adds New Developer Fees As Part of Play Store's DMA Compliance Plan

Par : BeauHD
7 mars 2024 à 00:20
An anonymous reader quotes a report from TechCrunch: Google today is sharing more details about the fees that will accompany its plan to comply with Europe's new Digital Markets Act (DMA), the new regulation aimed at increasing competition across the app store ecosystem. While Google yesterday pointed to ways it already complied with the DMA -- by allowing sideloading of apps, for example -- it hadn't yet shared specifics about the fees that would apply to developers, noting that further details would come out this week. That time is now, as it turns out. Today, Google shared that there will be two fees that apply to its External offers program, also announced yesterday. This new program allows Play Store developers to lead their users in the EEA outside their app, including to promote offers. With these fees, Google is going the route of Apple, which reduced its App Store commissions in the EU to comply with the DMA but implemented a new Core Technology Fee that required developers to pay 0.50 euros for each first annual install per year over a 1 million threshold for apps distributed outside the App Store. Apple justified the fee by explaining that the services it provides developers extend beyond payment processing and include the work it does to support app creation and discovery, craft APIs, frameworks and tools to support developers' app creation work, fight fraud and more. Google is taking a similar tactic, saying today that "Google Play's service fee has never been simply a fee for payment processing -- it reflects the value provided by Android and Play and supports our continued investments across Android and Google Play, allowing for the user and developer features that people count on," a blog post states. It says there will now be two fees that accompany External Offers program transactions: - An initial acquisition fee, which is 10% for in-app purchases or 5% for subscriptions for two years. Google says this fee represents the value that Play provided in facilitating the initial user acquisition through the Play Store. - An ongoing services fee, which is 17% for in-app purchases or 7% for subscriptions. This reflects the "broader value Play provides users and developers, including ongoing services such as parental controls, security scanning, fraud prevention, and continuous app updates," writes Google. Of note, a developer can opt out of the ongoing services and corresponding fees, if the user agrees, after two years. Users who initially installed the app believe they'll have services like parental controls, security scanning, fraud prevention and continuous app updates, which is why opting out requires user consent. Although Google allows the developer to terminate this fee, those ongoing services will no longer apply either. Developers, however, will still be responsible for reporting transactions involving those users who are continuing to receive Play Store services.

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Apple iPhone Sales In China Plummet As Huawei Soars

Par : BeauHD
7 mars 2024 à 01:00
Huawei is back from the dead after recording a sales jump of 64% in the first six weeks of 2024 compared to a year earlier. Meanwhile, Apple's iPhone sales in China fell by 24% during the same period. The BBC reports: Aside from a resurgence of Huawei sales at the more expensive end of the Chinese phone market, Apple was also "squeezed in the middle on aggressive pricing from the likes of Oppo, Vivo and Xiaomi," Counterpoint Research's Mengmeng Zhang wrote. China, which is one of Apple's biggest markets, also saw overall smartphone sales shrink by 7% in the same period, the report said. Huawei struggled for years due to US sanctions but its sales surged after releasing its Mate 60 series of 5G smartphones in August. It came as a major surprise as the Chinese firm was cut off from key chips and technology required for 5G mobile internet. Honor, which is the smartphone brand spun off from Huawei in 2020, was the only other top-five brand to see sales increase in China during the period, according to the report. Sales of Vivo, Xiaomi and Oppo also fell in the first six weeks of the year, Counterpoint said. Its report also said Apple's share of the Chinese smartphone market dropped to 15.7% from 19% last year, putting it in fourth place as it fell from the number two spot. Meanwhile, Huawei rose to second place as its market share grew to 16.5% from 9.4% a year earlier. Despite its sales falling by 15% over the last year, Vivo remained China's top-selling smartphone maker, Counterpoint said.

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Rising Temperatures and Heat Shocks Prompt Job Relocations, Study Finds

Par : BeauHD
7 mars 2024 à 01:40
dcblogs writes: A recent study in the National Bureau of Economic Research has found that companies are quietly adapting to rising temperatures by shifting operations from hotter to cooler locations. The researchers analyzed data from 50,000 companies between 2009 and 2020. "To illustrate the economic impact, the researchers found that when a company with equal employment across two counties experiences a heat shock in one county, there is a subsequent 0.7% increase in employment growth in the unaffected county over a three-year horizon," reports TechTarget. "The finding is significant, given that the mean employment growth for the sample of businesses in the study is 2.4%." Heat shocks are characterized by their severe impact on health, energy grids, and increased fire risks, influencing companies with multiple locations to reconsider their geographical distribution of operations. Despite this trend, states like Arizona and Nevada, which have some of the highest heat-related death tolls, continue to experience rapid business expansion. Experts believe that factors such as labor pool, taxes, and regulations still outweigh environmental climate risks when it comes to business site selection. But heat associated deaths are on the rise. In the Phoenix area alone, it experienced 425 heat related deaths in 2022 and a similar number in 2023 -- record highs for this region. The study suggests that the implications of climate change on business operations are becoming more apparent. Companies are beginning to evaluate climate risks as part of their regular risk assessment process.

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Former Google Engineer Indicted For Stealing AI Secrets To Aid Chinese Companies

Par : BeauHD
7 mars 2024 à 02:20
Linwei Ding, a former Google software engineer, has been indicted for stealing trade secrets related to AI to benefit two Chinese companies. He faces up to 10 years in prison and a $250,000 fine on each criminal count. Reuters reports: Ding's indictment was unveiled a little over a year after the Biden administration created an interagency Disruptive Technology Strike Force to help stop advanced technology being acquired by countries such as China and Russia, or potentially threaten national security. "The Justice Department just will not tolerate the theft of our trade secrets and intelligence," U.S. Attorney General Merrick Garland said at a conference in San Francisco. According to the indictment, Ding stole detailed information about the hardware infrastructure and software platform that lets Google's supercomputing data centers train large AI models through machine learning. The stolen information included details about chips and systems, and software that helps power a supercomputer "capable of executing at the cutting edge of machine learning and AI technology," the indictment said. Google designed some of the allegedly stolen chip blueprints to gain an edge over cloud computing rivals Amazon.com and Microsoft, which design their own, and reduce its reliance on chips from Nvidia. Hired by Google in 2019, Ding allegedly began his thefts three years later, while he was being courted to become chief technology officer for an early-stage Chinese tech company, and by May 2023 had uploaded more than 500 confidential files. The indictment said Ding founded his own technology company that month, and circulated a document to a chat group that said "We have experience with Google's ten-thousand-card computational power platform; we just need to replicate and upgrade it." Google became suspicious of Ding in December 2023 and took away his laptop on Jan. 4, 2024, the day before Ding planned to resign. A Google spokesperson said: "We have strict safeguards to prevent the theft of our confidential commercial information and trade secrets. After an investigation, we found that this employee stole numerous documents, and we quickly referred the case to law enforcement."

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VMware Sandbox Escape Bugs Are So Critical, Patches Are Released For End-of-Life Products

Par : BeauHD
7 mars 2024 à 03:30
An anonymous reader quotes a report from Ars Technica: VMware is urging customers to patch critical vulnerabilities that make it possible for hackers to break out of sandbox and hypervisor protections in all versions, including out-of-support ones, of VMware ESXi, Workstation, Fusion, and Cloud Foundation products. A constellation of four vulnerabilities -- two carrying severity ratings of 9.3 out of a possible 10 -- are serious because they undermine the fundamental purpose of the VMware products, which is to run sensitive operations inside a virtual machine that's segmented from the host machine. VMware officials said that the prospect of a hypervisor escape warranted an immediate response under the company's IT Infrastructure Library, a process usually abbreviated as ITIL. "In ITIL terms, this situation qualifies as an emergency change, necessitating prompt action from your organization," the officials wrote in a post. "However, the appropriate security response varies depending on specific circumstances." Among the specific circumstances, one concerns which vulnerable product a customer is using, and another is whether and how it may be positioned behind a firewall. A VMware advisory included the following matrix showing how the vulnerabilities -- tracked as CVE-2024-22252, CVE-2024-22253, CVE-2024-22254, CVE-2024-22255 -- affect each of the vulnerable products [...]. Three of the vulnerabilities affect the USB controller the products use to support peripheral devices such as keyboards and mice. Broadcom, the VMware parent company, is urging customers to patch vulnerable products. As a workaround, users can remove USB controllers from vulnerable virtual machines, but Broadcom stressed that this measure could degrade virtual console functionality and should be viewed as only a temporary solution. In an article explaining how to remove a USB controller, officials wrote: "The workaround is to remove all USB controllers from the Virtual Machine. As a result, USB passthrough functionality will be unavailable. In addition, virtual/emulated USB devices, such as VMware virtual USB stick or dongle, will not be available for use by the virtual machine. In contrast, the default keyboard/mouse as input devices are not affected as they are, by default, not connected through USB protocol but have a driver that does software device emulation in the guest OS. IMPORTANT: Certain guest operating systems, including Mac OS, do not support using a PS/2 mouse and keyboard. These guest operating systems will be left without a mouse and keyboard without a USB controller."

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New 'Water Batteries' Are Cheaper, Recyclable, And Won't Explode

Par : BeauHD
7 mars 2024 à 07:00
Clare Watson reports via ScienceAlert: By replacing the hazardous chemical electrolytes used in commercial batteries with water, scientists have developed a recyclable 'water battery' -- and solved key issues with the emerging technology, which could be a safer and greener alternative. 'Water batteries' are formally known as aqueous metal-ion batteries. These devices use metals such as magnesium or zinc, which are cheaper to assemble and less toxic than the materials currently used in other kinds of batteries. Batteries store energy by creating a flow of electrons that move from the positive end of the battery (the cathode) to the negative end (the anode). They expend energy when electrons flow the opposite way. The fluid in the battery is there to shuttle electrons back and forth between both ends. In a water battery, the electrolytic fluid is water with a few added salts, instead of something like sulfuric acid or lithium salt. Crucially, the team behind this latest advancement came up with a way to prevent these water batteries from short-circuiting. This happens when tiny spiky metallic growths called dendrites form on the metal anode inside a battery, busting through battery compartments. [...] To inhibit this, the researchers coated the zinc anode of the battery with bismuth metal, which oxidizes to form rust. This creates a protective layer that stops dendrites from forming. The feature also helps the prototype water batteries last longer, retaining more than 85 percent of their capacity after 500 cycles, the researchers' experiments showed. According to Royce Kurmelovs at The Guardian, the team has so far developed water-based prototypes of coin-sized batteries used in clocks, as well as cylindrical batteries similar to AA or AAA batteries. The team is working to improve the energy density of their water batteries, to make them comparable to the compact lithium-ion batteries found inside pocket-sized devices. Magnesium is their preferred material, lighter than zinc with a greater potential energy density. [I]f magnesium-ion batteries can be commercialized, the technology could replace bulky lead-acid batteries within a few years. The study has been published in the journal Advanced Materials.

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Teachers Are Embracing ChatGPT-Powered Grading

Par : BeauHD
7 mars 2024 à 10:00
Schools are widely adopting a new tool called Writable that uses ChatGPT to help grade student writing assignments. Axios reports: Writable, which is billed as a time-saving tool for teachers, was purchased last month by education giant Houghton Mifflin Harcourt, whose materials are used in 90% of K-12 schools. Teachers use it to run students' essays through ChatGPT, then evaluate the AI-generated feedback and return it to the students. A teacher gives the class a writing assignment -- say, "What I did over my summer vacation" -- and the students send in their work electronically. The teacher submits the essays to Writable, which in turn runs them through ChatGPT. ChatGPT offers comments and observations to the teacher, who is supposed to review and tweak them before sending the feedback to the students. Writable "tokenizes" students' information so that no personally identifying details are submitted to the AI program.

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Bipartisan Bill Could Force ByteDance To Divest TikTok

Par : BeauHD
7 mars 2024 à 13:00
An anonymous reader quotes a report from the BBC: A group of US lawmakers has introduced a bill that would require Chinese tech giant ByteDance to sell off the popular video-sharing TikTok app within six months or face a ban. For years American officials have raised concerns that data from the app could fall into the hands of the Chinese government. A bipartisan set of 19 lawmakers introduced the legislation on Tuesday. TikTok called the bill a disguised "outright ban." In a statement announcing the bill, the lawmakers said "applications like TikTok that are controlled by foreign adversaries pose an unacceptable risk to US national security." The bill would give ByteDance 165 days to divest, or it would be blocked from the app store and web hosting platforms in the US. TikTok has previously argued against divestment, saying a change in ownership would not impose new restrictions on data use. [...] The House Energy and Commerce Committee said it would consider the latest bill on Thursday. "This legislation will trample the First Amendment rights of 170 million Americans and deprive 5 million small businesses of a platform they rely on to grow and create jobs," TikTok said in a statement to the BBC. Former President Donald Trump attempted to completely ban TikTok in 2020, but that was unsuccessful. More recently, a group of senators introduced legislation to block TikTok last year, but it was stalled due to lobbying from the company.

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US Lost Record $12.5 Billion To Online Crime In 2023, Says FBI

Par : BeauHD
7 mars 2024 à 21:50
An anonymous reader quotes a report from BleepingComputer: FBI's Internet Crime Complaint Center (IC3) has released its 2023 Internet Crime Report (PDF), which recorded a 22% increase in reported losses compared to 2022, amounting to a record of $12.5 billion. The number of relevant complaints submitted to the FBI in 2023 reached 880,000, 10% higher than the previous year, with the age group topping the report being people over 60, which shows how vulnerable older adults are to cybercrime. Both figures continue a worrying trend seen by the agency since 2019, where complaints and losses rise yearly. For 2023, the types of crimes that increased were tech support scams and extortion, whereas phishing, personal data breach, and non-payment/non-delivery scams slightly waned.

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Researchers Jailbreak AI Chatbots With ASCII Art

Par : BeauHD
7 mars 2024 à 22:30
Researchers have developed a way to circumvent safety measures built into large language models (LLMs) using ASCII Art, a graphic design technique that involves arranging characters like letters, numbers, and punctuation marks to form recognizable patterns or images. Tom's Hardware reports: According to the research paper ArtPrompt: ASCII Art-based Jailbreak Attacks against Aligned LLMs, chatbots such as GPT-3.5, GPT-4, Gemini, Claude, and Llama2 can be induced to respond to queries they are designed to reject using ASCII art prompts generated by their ArtPrompt tool. It is a simple and effective attack, and the paper provides examples of the ArtPrompt-induced chatbots advising on how to build bombs and make counterfeit money. [...] To best understand ArtPrompt and how it works, it is probably simplest to check out the two examples provided by the research team behind the tool. In Figure 1 [here], you can see that ArtPrompt easily sidesteps the protections of contemporary LLMs. The tool replaces the 'safety word' with an ASCII art representation of the word to form a new prompt. The LLM recognizes the ArtPrompt prompt output but sees no issue in responding, as the prompt doesn't trigger any ethical or safety safeguards. Another example provided [here] shows us how to successfully query an LLM about counterfeiting cash. Tricking a chatbot this way seems so basic, but the ArtPrompt developers assert how their tool fools today's LLMs "effectively and efficiently." Moreover, they claim it "outperforms all [other] attacks on average" and remains a practical, viable attack for multimodal language models for now.

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Apple Will Cut Off Third-Party App Store Updates If Your iPhone Leaves the EU For a Month

Par : BeauHD
7 mars 2024 à 23:10
In an updated support page, Apple says it won't let your iPhone update software installed by third-party app stores if you leave the European Union for more than 30 days. The Verge reports: Shortly after the EU's Digital Markets Act (DMA) went into effect on Wednesday, users noticed an Apple support page stating users would "lose access to some features" when leaving the EU "for short-term travel." But now, Apple has made this policy more specific by carving out a 30-day grace period, which could be inconvenient for frequent travelers. This doesn't change your ability to use alternative app marketplaces, however, as Apple says you can still use third-party stores to manage apps you've already installed. Further reading: Apple is Working To Make It Easier To Switch From iPhone To Android Because of the EU

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Is America Running Out of Electrical Power?

Par : BeauHD
7 mars 2024 à 23:50
An anonymous reader quotes a report from The Week Magazine: The advancement of new technologies appears to have given rise to a new problem across the United States: a crippling power shortage on the horizon. The advent of these technologies, such as eco-friendly factories and data centers, has renewed concerns that America could run out of electrical power. These worries also come at a time when the United States' aging power grid is in desperate need of repair. Heavily publicized incidents such as the 2021 Texas power outage, which was partially blamed on crypto-farming, exposed how vulnerable the nation's power supply is, especially during emergencies. There have also been warnings from tech moguls such as Elon Musk, who has stated that the United States is primed to run out of electricity and transformers for artificial intelligence in 2025. But the push to extend the life of the nation's power grid, while also maintaining eco-friendly sustainability, begs the question: Is the United States really at risk of going dark? The emergence of new technologies means demand is soaring for power across the country; in Georgia, "demand for industrial power is surging to record highs, with the projection of electricity use for the next decade now 17 times what it was only recently," Evan Halper said for The Washington Post. Northern Virginia "needs the equivalent of several large nuclear power plants to serve all [its] new data centers," Halper said, while Texas faces a similar problem. This demand is resulting in a "scramble to try to squeeze more juice out of an aging power grid." At the same time, companies are "pushing commercial customers to go to extraordinary lengths to lock down energy sources, such as building their own power plants," Halper said. Much of this relates to the "rapid innovation in artificial intelligence, which is driving the construction of large warehouses of computing infrastructure," Halper said. This infrastructure requires significantly more power than traditional data centers, with the aforementioned crypto farms also sucking up massive amounts of power. Climate change is also hurting sustainability efforts. A recent report from the North American Electric Reliability Corporation estimated that more than 300 million people in the U.S. and Canada could face power shortages in 2024. It also found that electricity demand is rising faster now than at any time in the past five years. This is partially because the "push for the electrification of heating and transportation systems -- including electric cars -- is also creating new winter peaks in electricity demand," Jeremy Hsu said for New Scientist. One of the main issues with these sustainability efforts is the push to move away from fossil fuels toward renewable power. Natural gas is often seen as a bridge between fossils and renewables, but this has also had unintended consequences for the power grid. The system delivering natural gas "doesn't have to meet the same reliability standards as the electric grid, and in many cases, there's no real way to guarantee that fuel is available for the gas plants in the winter," Thomas Rutigliano of the Natural Resources Defense Council said to New Scientist. As a result, the "North American electricity supply has become practically inseparable from the natural gas supply chain," John Moura of the North American Electric Reliability Corporation said to New Scientist. As such, a "reliable electricity supply that lowers the risk of power outages depends on implementing reliability standards for the natural gas industry moving forward," but this may be easier said than done.

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Fedora Workstation 41 To No Longer Install GNOME X.Org Session By Default

Par : BeauHD
8 mars 2024 à 00:30
Michael Larabel writes via Phoronix: Fedora Workstation has long defaulted to using GNOME's Wayland session by default, but it has continued to install the GNOME X.Org session for fallback purposes or those opting to use it instead. But for the Fedora Workstation 41 release later in the year, there is a newly-approved plan to no longer have that GNOME X.Org session installed by default. Recently there was a Fedora Workstation ticket opened to no longer install the GNOME X.Org session by default. This is just about whether the X.Org session is pre-installed but would continue to live in the repository for those wanting to explicitly install it. The Fedora Workstation working group decided to go ahead with this change for the Fedora 41 cycle, not the upcoming Fedora 40 release. So pending any obstacles by FESCo, which is unlikely. Fedora Workstation 41 will not be installing the GNOME X.Org session by default. Long live Wayland.

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Reddit Will Now Use an AI Model To Fight Harassment

Par : BeauHD
8 mars 2024 à 01:30
An APK teardown performed by Android Authority has revealed that Reddit is now using a Large Language Model (LLM) to detect harassment on the platform. From the report: Reddit also updated its support page a week ago to mention the use of an AI model as part of its harassment filter. "The filter is powered by a Large Language Model (LLM) that's trained on moderator actions and content removed by Reddit's internal tools and enforcement teams," reads an excerpt from the page. The Register reports: The filter can be enabled in a Reddit community's mod tools, but individual moderators will need to have permissions to change subreddit settings to enable it. The harassment filter can be set to low ("filters the least content but with the most accurate results") and high ("filters the most content but may be less accurate"), and also includes an explicit allow list to force the AI to ignore certain keywords, up to 15 of which can be added. Once enabled, the filter creates a new tag in the moderation queue called "potential harassment," which moderators can review for accuracy. Reddit's help page says the feature is now available on desktop and the official Reddit apps, though it's not clear when the feature was added.

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Company That Plans To Bring Back the Mammoth Takes a Key Step

Par : BeauHD
8 mars 2024 à 02:10
John Timmer reports via Ars Technica: A company called Colossal plans to pioneer the de-extinction business, taking species that have died within the past few thousand years and restoring them through the use of DNA editing and stem cells. It's grabbed headlines recently by announcing some compelling targets: the thylacine, an extinct marsupial predator, and an icon of human carelessness, the dodo. But the company was formed to tackle an even more audacious target: the mammoth, which hasn't roamed the Northern Hemisphere for thousands of years. Obviously, there are a host of ethical and conservation issues that would need to be worked out before Colossal's plans go forward. But there are some major practical hurdles as well, most of them the product of the distinct and extremely slow reproductive biology of the mammoth's closest living relatives, the elephants. At least one of those has now been cleared, as the company is announcing the production of the first elephant stem cells. The process turned out to be extremely difficult, suggesting that the company still has a long road ahead of it. [...] Overall, it's a project that has a high probability of failure and may ultimately require generations of scientists. If we do successfully de-extinct a species, the first example will probably be a different species, even though the projects launched later. But Colossal is forging ahead and cleared one of the many hurdles it faces: It created the first induced stem cells from elephants and will be placing a draft manuscript describing the process on a public repository on Wednesday. (Colossal provided Ars with an advanced version of the draft that, outside of a few editing errors, appears largely complete.) Beyond providing the technical details of how the process works, the manuscript describes a long, failure-ridden route to eventual success. Several methods have been developed to allow us to induce stem cells from the cells of an adult organism. The original Nobel-winning process developed by Shinya Yamanaka involved inserting the genes that encode four key embryonic regulatory genes into adult cells and allowing them to reprogram the adult cell into an embryonic state. That has proven effective in a variety of species but has a couple of drawbacks due to the fact that the four genes can potentially stick around, interfering with later development steps. Although there are ways around that, others have developed a cocktail of chemicals that perform a similar function by activating signaling pathways that, collectively, can also reprogram adult cells. When it works, this simplifies matters, as you only have to remove the chemicals to allow the stem cells to adopt other fates. Colossal tried both of these. Neither worked with elephant cells: "Multiple attempts with current standard reprogramming methods were tried, and failed, and resulted in no, or incomplete, reprogramming." Apparently, lots of additional trial and error ensued. The eventual solution ended up being based in part on combining the two primary options: Cells were first exposed to a chemical reprogramming cocktail and then given the four genes used in the alternative reprogramming method. On its own, however, that wasn't enough. The researchers also had to address a quirk of elephant biology. Obviously, for Colossal, this is a means to an end: the mammoth. But that's remarkably underplayed in the manuscript. Instead, its emphasis is on the technology's use in the conservation of existing species. [T]he researchers note that studying things like elephant development and metabolism in actual elephants is not especially realistic. But we can potentially induce the stem cells developed here into any cell we'd want to study -- nerve, liver, heart, and so on. So, the stem cells described here could be a useful tool for research. So, these cells are being presented as a valuable tool for the research community. Still, you can expect the people behind the de-extinction project to be getting to work on some of the easier things: showing that the genome in the cells can be edited and that they can be induced to start the process of embryogenesis. Separately, some unfortunate individuals will need to be working on the hard problems we mentioned earlier.

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Microscopic Plastics Could Raise Risk of Stroke and Heart Attack, Study Says

Par : BeauHD
8 mars 2024 à 03:30
An anonymous reader quotes a report from The Guardian: Doctors have warned of potentially life-threatening effects from plastic pollution after finding a substantially raised risk of stroke, heart attack and earlier death in people whose blood vessels were contaminated with microscopic plastics. Researchers in Naples examined fatty plaques removed from the blood vessels of patients with arterial disease and found that more than half had deposits contaminated with tiny particles of polyethylene or polyvinyl chloride (PVC). Those whose plaques contained microplastics or nanoplastics were nearly five times more likely to suffer a stroke, heart attack or death from any cause over the following 34 months, compared with those whose plaques were free from plastic contamination. The findings do not prove that plastic particles drive strokes and heart attacks -- people who are more exposed to the pollution may be at greater risk for other reasons -- but research on animals and human cells suggests the particles may be to blame. [...] Writing in the New England Journal of Medicine, the doctors describe how they analyzed fatty plaques removed from 304 patients with atherosclerosis affecting the carotid arteries. The carotid arteries are the main blood vessels that supply blood to the neck, face and brain. The disease causes a build-up of plaque in the arteries, which substantially raises the risk of stroke. The plaques can be removed by a procedure called carotid endarterectomy. Lab tests on the extracted plaques revealed polyethylene in 150 patients and polyvinyl chloride in 31, alongside signs of inflammation. On examination under an electron microscope, the researchers spotted jagged foreign particles in the fatty deposits, most less than a thousandth of a millimeter across. The doctors followed 257 of the patients for an average of 34 months after they had carotid plaques removed. Those who had plastic particles in their plaques were 4.5 times more likely to have a stroke or heart attack, or to die from any cause, than those whose plaques were free from plastic pollution. "People must become aware of the risks we are taking with our lifestyle," said Dr Raffaele Marfella, first author on the study at the University of Campania Luigi Vanvitelli in Naples. "I hope the alarm message from our study will raise the consciousness of citizens, especially governments, to finally become aware of the importance of the health of our planet. To put it in a slogan that can unite the need for health for humans and the planet, plastic-free is healthy for the heart and the Earth."

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