An anonymous reader shares a report: More than 2% of Americans are taking the blockbuster class of GLP-1 drugs for overweight or obesity, up nearly 600% over six years, according to a report from FAIR Health given to Axios first. The data from FAIR Health's repository of over 51 billion commercial healthcare claim records shows the explosion in use of the drugs specifically for weight loss -- roughly half of all users. In all, roughly 4% of Americans were taking GLP-1 drugs in 2024 for either overweight, obesity or Type 2 diabetes (their original approved use). The data shows Novo Nordisk's Ozempic is still by far the most commonly taken GLP-1, followed by Eli Lilly's Mounjaro. The percentage of adults who were prescribed a GLP-1 drug but did not have bariatric surgery increased from 2.5% in 2019 to 11.2% in 2024 while the the percentage of adult patients who had bariatric surgery decreased 41.8%.

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Researchers are developing techniques to genetically modify cancer-fighting immune cells directly inside patients rather than in expensive laboratory facilities, potentially making CAR-T therapy accessible to far more people. Current CAR-T treatments require removing a patient's T cells, shipping them to specialized facilities for genetic engineering, then returning them weeks later at costs around $500,000 per dose. The new "in vivo" approaches use viral vectors or RNA-loaded nanoparticles to deliver genetic instructions directly to T cells circulating in the bloodstream, which could reduce costs by an order of magnitude. Companies including Capstan Therapeutics, co-founded by Nobel laureates, and AstraZeneca-backed EsoBiotec have launched early human trials. While only about 200 US centers currently offer traditional CAR-T therapy, the approach could make the powerful treatment available on demand like conventional drugs.

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German sportswear giant Adidas disclosed a data breach after attackers hacked a customer service provider and stole some customers' data. From a report: "adidas recently became aware that an unauthorized external party obtained certain consumer data through a third-party customer service provider," the company said. "We immediately took steps to contain the incident and launched a comprehensive investigation, collaborating with leading information security experts." Adidas added that the stolen information did not include the affected customers' payment-related information or passwords, as the threat actors behind the breach only gained access to contact. The company has also notified the relevant authorities regarding this security incident and will alert those affected by the data breach.

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More than 50 years after its debut, Uno has achieved unprecedented popularity among adults, but its resurgence is creating problems and confusions as players disagree on fundamental rules. WSJ, in a fun story [non-paywalled source]: Think politics divides? Try mixing competitors with different views on stacking "action" cards, or getting everyone to agree on the true power of the Wild card. And nobody can seem to decide whether staples of the game of their youth -- like mandating players yell "Uno!" when they have one card left -- are socially acceptable at a bar with strangers. Mattel has responded by actively settling rule debates on social media, definitively stating that stacking Draw 2 cards is prohibited, while simultaneously embracing the game's divisive nature through marketing campaigns. The company's "Show 'Em No Mercy" variant, featuring more aggressive rules, became the second-best-selling card game in the United States last year according to research firm Circana, trailing only classic Uno itself.

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The Browser Company has ceased the active development of its Arc browser to focus on Dia, a new AI-powered browser currently in alpha testing, the company said Tuesday. In a lengthy letter to users, CEO Josh Miller said the startup should have stopped working on Arc "a year earlier," noting data showing the browser suffered from a "novelty tax" problem where users found it too different to adopt widely. Arc struggled with low feature adoption -- only 5.52% of daily active users regularly used multiple Spaces, while 4.17% used Live Folders. The company will continue maintenance updates for Arc but won't add new features. Arc also won't open-source the browser because it relies on proprietary infrastructure called ADK (Arc Development Kit) that remains core to the company's value.

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President Trump's threat of a 25% tariff on smartphone imports including iPhones would not provide enough economic incentive for Apple to relocate US-bound iPhone production to domestic facilities, according to a new Morgan Stanley note viewed by Slashdot. The tariff threat, announced Friday via social media, appeared to target Apple's recent shift of iPhone production from China to India through its contract manufacturing partners. Morgan Stanley analysts estimate that establishing US iPhone production would require a minimum of two years and several billion dollars to build multiple greenfield assembly facilities, with a trained workforce exceeding 100,000 workers during peak seasons. More significantly, the firm calculates that a US-produced iPhone would cost 35% more than current China or India production, primarily due to higher labor costs and the need to import 25% of iPhone components from China under existing 30% tariffs. By contrast, Apple could offset a 25% import tariff by raising global iPhone prices just 4-6%, making domestic production economically unviable.

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Abstract of a paper on NBER: We elicited over a million stated preference choices over 126 dimensions or "aspects" of well-being from a sample of 3,358 respondents on Amazon's Mechanical Turk (MTurk). Our surveys also collected self-reported well-being (SWB) questions about respondents' current levels of the aspects of well-being. From the stated preference data, we estimate relative log marginal utilities per point on our 0-100 response scale for each aspect. We validate these estimates by comparing them to alternative methods for estimating preferences. Our findings provide empirical evidence that both complements and challenges philosophical perspectives on human desires and values. Our results support Aristotelian notions of eudaimonia through family relationships and Maslow's emphasis on basic security needs, yet also suggest that contemporary theories of well-being may overemphasize abstract concepts such as happiness and life satisfaction, while undervaluing concrete aspects such as family well-being, financial security, and health, that respondents place the highest marginal utilities on. We document substantial heterogeneity in preferences across respondents within (but not between) demographic groups, with current SWB levels explaining a significant portion of the variation.

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The European Commission warned Chinese e-tailer SHEIN on Monday that it must address multiple consumer law violations or face fines across EU member states. Regulators found SHEIN's website displayed fake discounts not based on actual prior prices, used pressure-selling tactics with false purchase deadlines, provided misleading information about consumer return rights, made deceptive sustainability claims, and hid contact details from customers. SHEIN has one month to respond to the findings and propose corrective measures, adding regulatory pressure to a company already facing US tariff challenges despite generating an estimated $38 billion in revenue last year.

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California's population grew 0.6% in 2024, adding nearly 250,000 residents to reach 39.43 million, according to Census Bureau estimates. The growth came entirely from a rebound in international immigration, which surged to over 300,000 people after plunging to 44,000 during the pandemic's worst year. Without immigration, the state would have shrunk significantly as domestic migration remained negative. The H-1B visa program alone brought nearly 79,000 skilled workers to California in 2024. Since 2010, California has added 2.7 million immigrants, with half coming from Asia and slightly more than a third from Latin America. The immigration-dependent growth model puts California at particular risk from potential federal policy changes, as more than a quarter of its population is foreign-born -- the highest share nationwide.

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Nikon will raise prices on its cameras and imaging products in the United States starting June 23, citing President Donald Trump's tariffs on Chinese-made goods as the reason for what the company calls a "necessary price adjustment." The Japanese camera maker joins a growing list of photography equipment manufacturers implementing price increases, including Canon, Sony, Leica, and lens maker Sigma. Nikon told investors the tariffs could slash its profits by 10 billion yen ($70 million) in the upcoming fiscal year, though the company has not disclosed which specific products will see increases or by how much prices will rise.

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New submitter zuki shares an obit published at The Register: John Young, the co-founder of the legendary internet archive Cryptome, died at the age of 89 on March 28. The Register talked to friends and peers who gave tribute to a bright, pugnacious man who was devoted to the public's right to know. Before WikiLeaks, OpenLeaks, BayFiles, or Transparency Toolkit, there was Cryptome - an open internet archive that inspired them all, helped ignite the first digital crypto war, and even gave Julian Assange his start before falling out with him on principle.

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alternative_right writes: The site looks like an ordinary Star Wars fan website from around 2010. But starwarsweb.net was actually a tool built by the Central Intelligence Agency (CIA) to covertly communicate with its informants in other countries.

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As policy makers in the UK weigh how to regulate the AI industry, Nick Clegg, former UK deputy prime minister and former Meta executive, claimed a push for artist consent would "basically kill" the AI industry. From a report: Speaking at an event promoting his new book, Clegg said the creative community should have the right to opt out of having their work used to train AI models. But he claimed it wasn't feasible to ask for consent before ingesting their work first. "I think the creative community wants to go a step further," Clegg said according to The Times. "Quite a lot of voices say, 'You can only train on my content, [if you] first ask.' And I have to say that strikes me as somewhat implausible because these systems train on vast amounts of data." "I just don't know how you go around, asking everyone first. I just don't see how that would work," Clegg said. "And by the way if you did it in Britain and no one else did it, you would basically kill the AI industry in this country overnight."

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Newark Liberty International Airport has suffered six radar and radio outages in nine months, with the most recent occurring May 9th when controllers told pilots "our scopes just went black again" before handing off flights to other facilities. The outages have forced flight cancellations, diversions, and delays lasting over a week as airlines repositioned aircraft and crews. The Federal Aviation Administration created the problem by relocating Newark's air traffic control operations from the understaffed N90 facility on Long Island to Philadelphia in 2024. Only 17 of 33 controllers accepted the move despite $100,000 relocation bonuses, leaving operations short-staffed. Rather than build new STARS servers in Philadelphia, the FAA opted to send radar data over 130 miles of commercial copper telephone lines. The remote feeds have experienced approximately 10 minutes of downtime over 10 months -- exceeding the agency's reliability standards and occurring 200 times more frequently than the FAA's internal analysis predicted. The agency simultaneously laid off over 100 maintenance technicians and telecommunications specialists in February, further straining an air traffic control system that suffers around 700 outages weekly nationwide while managing 16.8 million annual flights with 1990s-era technology.

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An anonymous reader shares a report: Russian President Vladimir Putin said on Monday that foreign service providers like Microsoft and Zoom that act against Russian interests should be "throttled." Putin said it was important for Russia to develop domestic software solutions.

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Pakistan will allocate 2,000 megawatts (MW) of electricity in the first phase of a national initiative to power bitcoin mining and AI data centres, its finance ministry said on Sunday. The allocation is part of Islamabad's plans to use its surplus electricity to bitcoin mining and AI data centres.

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Amazon software engineers are reporting that AI tools are transforming their jobs into something resembling the company's warehouse work, with managers pushing faster output and tighter deadlines while teams shrink in size, according to the New York Times. Three Amazon engineers told the New York Times that the company has raised productivity goals over the past year and expects developers to use AI assistants that suggest code snippets or generate entire program sections. One engineer said his team was cut roughly in half but still expected to produce the same amount of code by relying on AI tools. The shift mirrors historical workplace changes during industrialization, the Times argues, where technology didn't eliminate jobs but made them more routine and fast-paced. Engineers describe feeling like "bystanders in their own jobs" as they spend more time reviewing AI-generated code rather than writing it themselves. Tasks that once took weeks now must be completed in days, with less time for meetings and collaborative problem-solving, according to the engineers.

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An anonymous reader shares a report: [Last] week, it was announced that Docomo's emoji designs will no longer appear on any of the Japanese mobile network's devices. This marks the end of an emoji era that first began in 1999, even though the set hasn't been updated since 2013. [...] Unlike these earlier systems, Docomo's emoji set in 1999 was explicitly tied to mobile internet use and would become the template for emoji standardization in the 2000s and 2010s, alongside emoji design sets implemented by Softbank and KDDI on their own versions of i-mode (J-Sky and EZweb, respectively). Docomo's set would receive several updates between 1999 and 2013, introducing color support and additional concepts to the keyboard. But now, as per this week's announcement, it will finally be discontinued. Spanning 26 years, it's undeniable that Docomo's emoji set played a foundational role in emoji history, even if its last incarnation remained unchanged for almost 12 of those 26 years.

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Venture capitalists are inverting their traditional investment approach by acquiring mature businesses and retrofitting them with AI. Firms including General Catalyst, Thrive Capital, Khosla Ventures and solo investor Elad Gil are employing this private equity-style strategy to buy established companies like call centers and accounting firms, then optimizing them with AI automation.

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"For decades, Hollywood directors including Stanley Kubrick, James Cameron and Alex Garland have cast AI as a villain that can turn into a killing machine," writes the Los Angeles Times. "Even Steven Spielberg's relatively hopeful A.I.: Artificial Intelligence had a pessimistic edge to its vision of the future." But now "Google — a leading developer in AI technology — wants to move the cultural conversations away from the technology as seen in The Terminator, 2001: A Space Odyssey and Ex Machina.". So they're funding short films "that portray the technology in a less nightmarish light," produced by Range Media Partners (which represents many writers and actors) So far, two short films have been greenlit through the project: One, titled "Sweetwater," tells the story of a man who visits his childhood home and discovers a hologram of his dead celebrity mother. Michael Keaton will direct and appear in the film, which was written by his son, Sean Douglas. It is the first project they are working on together. The other, "Lucid," examines a couple who want to escape their suffocating reality and risk everything on a device that allows them to share the same dream.... Google has much riding on convincing consumers that AI can be a force for good, or at least not evil. The hot space is increasingly crowded with startups and established players such as OpenAI, Anthropic, Apple and Facebook parent company Meta. The Google-funded shorts, which are 15 to 20 minutes long, aren't commercials for AI, per se. Rather, Google is looking to fund films that explore the intersection of humanity and technology, said Mira Lane, vice president of technology and society at Google. Google is not pushing their products in the movies, and the films are not made with AI, she added... The company said it wants to fund many more movies, but it does not have a target number. Some of the shorts could eventually become full-length features, Google said.... Negative public perceptions about AI could put tech companies at a disadvantage when such cases go before juries of laypeople. That's one reason why firms are motivated to makeover AI's reputation. "There's an incredible amount of skepticism in the public world about what AI is and what AI will do in the future," said Sean Pak, an intellectual property lawyer at Quinn Emanuel, on a conference panel. "We, as an industry, have to do a better job of communicating the public benefits and explaining in simple, clear language what it is that we're doing and what it is that we're not doing."

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